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Anti-stress and Promoting Effect of the Fruit of Morus alba  

Hwang, Keum-Hee (Bio-Food and Drug Research Center, Konkuk University)
Publication Information
Korean Journal of Food Science and Technology / v.37, no.1, 2005 , pp. 95-102 More about this Journal
Abstract
Effects of Morus alba fruit extracts on monoamine oxidase (MAO) activity were examined in rats during and after physical exercise. Oral administration of M. alba extract (0.3 g/kg body weight) significantly increased brain MAO-A activity but decreased liver MAO-B activity when they were measured using serotonin and benzylamine as substrates. Type of physical exercises had significant effect on MAO activity. Brain MAO-A activity markedly decreased with physical activity-related stress compared to normal group, whereas Liver MAO-B activity increased up to 60 min after exercise. Lactate dehydrogenase (LDH) activity and lactate concentration in blood, clinical indices of physical exercise activities, were also determined for correlation to MAO activities. MAO-A activity of rats subjected to oral administration of M. alba extract and physical exercise increased whereas MAO-B and LDH activities, and lactate level decreased, All indices eventually recovered normal levels, These results suggest M. alba may increase capability of physical activities by modulating MAO activities during exercise.
Keywords
monoamine oxidase (MAO); lactate dehydrogenase (LDH); Morus alba; exercise; anti-stress effect;
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