Browse > Article

In Vitro Effect of Yuza (Citrus junos SIEB ex TANAKA) Extracts on Proliferation of Human Prostate Cancer Cells and Antioxidant Activity  

Yoo, Kyung-Mi (Department of Food and Nutrition, College of Human Ecology, Seoul National University)
Hwang, In-Kyeong (Department of Food and Nutrition, College of Human Ecology, Seoul National University)
Publication Information
Korean Journal of Food Science and Technology / v.36, no.2, 2004 , pp. 339-344 More about this Journal
Abstract
Effects of 18 kinds of yuza extracts on viability of prostate cancer cells, DU 145 and LN-CaP, were investigated. Chloroform and methanolic extracts of yuza peel exhibited moderate cytotoxicity against both cancer cell lines dose-dependently and also showed antioxidant activity matching on inhibition of cell viability (author's intension not clear). Chloroform extract of yuza peel exhibited highest radical-scavenging activity and cytotoxicity against prostate cancer cells in vitro.
Keywords
Citrus junos SIEB ex TANAKA; polyphenol; prostate cancer cell; antioxidant activity; cytotoxicity;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Willet CW. Diet and health: What should we eat? Science 264: 532-537 (1994)   DOI
2 Lee KW, Lee HJ, Kang KS, Lee CY. Preventive effects of vitamin C on carcinogenesis. Lancet 359:172-176 (2002)   DOI   ScienceOn
3 Hertog MG, Feskeens JM, Hollman CH, Katan MB, Kromhout D. Dietary antioxidant flavonoids and risk of coronary heart disease. Lancet 342: 1007-1011 (1993)   DOI   ScienceOn
4 Nakanishi M, Hisatake M. Studies on the using of yuza (Citrus junos) juice in food industry field. New Food Ind. 17: 39-45 (1988)
5 Lee HY, Kim YM, Shin DH, Sun BK. Aroma Components in Korean citron (Citrus medica). Korean J. Food Sci. Technol. 19: 361-365 (1987)
6 Dabrowska-Ufniarz E, Dzieniszewski J, Jarosz M, Wartanowicz M. Vitamin C concentration in gastric juice in patients with precancerous lesions of the stomach and gastric cancer. Med. Sci. Monit. 8: 96-103 (2002)
7 Yamasaki Y, Hisatake M. On the quality of yuza (citrus junos) juice produced in kochi prefecture. Kochi Food Ind. 2: 44-51 (1990)
8 Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. Quantitation of flavonoid constituents in citrus fruits. J. Agric. Food Chem. 47: 3565-3571 (1999)   DOI   ScienceOn
9 Chu YH, Chan CL, Hsu HF. Flavonid content of several vegetables and their antioxidant mushrooms (Agricus bisporus). J. Sci. Food Agric. 80: 561-566 (2000)   DOI   ScienceOn
10 Drake IM, Davies MJ, Mapstone NP, Dixon MF, Schorah CJ, White KL, Chalmers DM, Axon AT. Ascorbic acid may protect against human gastric cancer by scavenging mucosal oxygen radicals. Carcinogenesis 17: 559-562 (1996)   DOI   ScienceOn
11 Wang H, Cao G, Prior RL. Total antioxidant capacity of fruits. J. Agric. Food Chem. 44: 701-705 (1996)   DOI   ScienceOn
12 Ames BM, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. 90: 7915-7922 (1993)   DOI
13 Lee CY, Smith NL. Apples: An important source of antioxidants in the American diet. N.Y. Fruit Q. 8: 15-17 (2000)
14 Jeoung JW, Kwon DJ, Hwang JB, Jo YJ. Influence of the extraction method on quality of citron juice. Korean J. Food Sci. Technol. 26: 704-708 (1994)
15 Kotake-Nara E, Kuchiro M, Zhang H, Sugawara T, Miyashita, Nagao A. Carotenoids affect proliferation of human prostate cancer cells. J. Nutr. 131: 3303-3306 (2001)   DOI
16 Jane M. Dairy food, dairy fat, and cancer: A review of epidemiological evidence. Nutr. Res. 18: 905-937 (1998)   DOI   ScienceOn
17 Jeoung JW, Lee YC, Kim JH, Kim OW, Nahmgung B. Cooling properties and quality changes during storage of citron (Citrus junos). Korean J. Food Sci. Technol. 28: 1071-1077 (1996)
18 Johnson MK, Loo G. Effects of epigallocatechin gallate and quercetin on oxidative damage to cellular DNA. Mutat. Res. 459: 211-218 (2000)   DOI   ScienceOn
19 Vinson JA, Su X, Zubik, Bose P. Phenol antioxidant quantity and quality in food: Fruits. J. Agric. Food Chem. 49: 5315-5321 (2001)   DOI   ScienceOn
20 Yamasaki Y, Hisatake M, Nakanishi M. Long-term frozen storage of yuza (Citrus junos) juice produced in business container. Kochi Food Ind. 20: 34-45 (1989)
21 Lee YC, Kim IH, Jeoung JW, Kim HK, Park MH. Chemical characteristics of citron (Citrus junos) juice. Korean J. Food Sci. Technol. 26: 552-556 (1994)