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Differences of Hematopoietic Effects of Angelica gigas, A. sinensis and A. acutiloba Extract on Cyclophosphamide-induced Anemic Rats  

Kang, Soon-Ah (Bio/Molecular Informatics Center, Department of Molecular Biotechnology, Konkuk University)
Jang, Ki-Hyo (Department of Food and Nutrition, Samcheok National University)
Lee, Ji-Eun (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Ahn, Duk-Kyun (Jaseng Research Institute of Biotechnology and Bioscience)
Park, Seong-Kyu (Department of Prescriptionology, College of Oriental Medicine, Kyung Hee University)
Publication Information
Korean Journal of Food Science and Technology / v.35, no.6, 2003 , pp. 1204-1208 More about this Journal
Abstract
The purpose of this study was to compare the hematopoietic effects of Angelica gigas, A. sinensis, and A. acutiloba extract (1 g/kg B.W.) on cyclophosphamide-induced (30 mg/kg B.W.) anemic rats. Cyclophosphamide injection group (AG, AS, AA) showed a decrease in weight gain in comparison with the normal group. Compared to the cyclophosphamide-treated control group, oral administration of Angelica gigas extract for 14 days in the normal group significantly prevented body weight loss. The iron level of the A. gigas-administered group was significantly higher than the control groups. The serum vitamin $B_{12}$ level of A. gigas-, A. sinensis-, and A. acutiloba-administered groups was significantly higher than in the control. We suggest that administration of A. gigas, A. sinensis, and A. acutiloba prevents cyclophosphamide-induced anemia by improving hematological value and iron status.
Keywords
cyclophosphamide; Angelica gigas; A. sinensis; A. acutiloba; anemic condition; iron level; vitamin $B_{12}$;
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