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Effects of Butanol Fraction of Alisma canaliculatum with Vitamin E on Plasma Levels of Glucose and Lipid in Streptozotocin-Induced Diabetic Rats  

Lim, Sook-Ja (Department of Foods and Nutrition, College of Natural Sciences, Duksung Women's University)
Park, Ji-Eun (Department of Foods and Nutrition, College of Natural Sciences, Duksung Women's University)
Publication Information
Korean Journal of Food Science and Technology / v.35, no.4, 2003 , pp. 713-719 More about this Journal
Abstract
The effects of butanol (BuOH) fraction of Alisma canaliculatum (Ac) with vitamin E in streptozotocin (STZ)-induced diabetic rats were determined. Sprague-Dawley rats were divided into 5 groups: normal, STZ-control, and 3 diabetic-experimental groups. Diabetes mellitus was induced by injection of STZ (45 mg/kg) into the tail vein. The BuOH fraction of Ac and vitamin E were administrated orally in experimental rats for 21 days: Ac group (400 mg/kg), Ac-VE group (Ac 400 mg/kg & vitamin E 10 mg/kg), and VE group (vitamin E 10 mg/kg). The body weight losses were seen in all groups except normal, and the decrements in experimental groups were less than that in diabetic-control group. The plasma glucose levels were significantly lower in Ac group compared to STZ-control group on 21 day (p<0.05). The plasma level of insulin was slightly higher in AC-VE group than other diabetic groups. The plasma cholesterol levels of diabetic-experimental groups were significantly lower than those of STZ-control group on 14 day (p<0.05). ALT and AST activities of diabetic-experimental groups were significantly lower than that of STZ-control group (p<0.05). The results suggested that the BuOH fraction of Ac might possess hypoglycemic properties in STZ-induced diabetic rats and no synergistic effect of vitamin E was seen during the experimental period.
Keywords
Alisma canaliculatum; vitamin E; diabetes; glucose level; lipid level;
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