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A Study on the Longitudinal Bone Growth of Growth-stimulating Material with Eleutherococcus senticosus  

Yang, Dong-Sik (Korea Institute of Oriental Medicine)
Cha, Min-Ho (Korea Institute of Oriental Medicine)
Kang, Bong-Joo (Korea Institute of Oriental Medicine)
Oh, Se-Wook (Korea Food Research Institute)
Kim, Young-Eon (Korea Food Research Institute)
Yoon, Yoo-Sik (Korea Institute of Oriental Medicine)
Publication Information
Korean Journal of Food Science and Technology / v.35, no.4, 2003 , pp. 702-707 More about this Journal
Abstract
This study was conducted to evaluate the effect of a growth-stimulating material (GSM) containing Eleutherococcus senticosuson on the longitudinal bone growth. The effects of GSM on proliferation zone and IGF-1 mRNA expression in rat growth plate, IGF-1 mRNA expression in MG-63 osteoblast and Hep-G2 hepatocyte, and bone growth of mouse tibia were studied. GSM significantly increased the proliferation zone in growth plate of proximal tibia (P<0.001) and the IGF-1 mRNA expression in growth plate was also increased (P<0.01). Treatment of GSM to MG-63 osteoblast and Hep-G2 hepatocyte also increased IGF-1 mRNA expression more than twice. In addition, bone mineral density of mouse tibia was significantly increased by GSM (P<0.05). Therefore, it was shown that GSM has an activity of bone growth promotion by increasing the expression of IGF-1, a major bone growth factor.
Keywords
Eleutherococcus senticosuson; growth plate; Hep-G2; IGF-1; MG-63;
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