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Effects of Tissue Cultured Ginseng on Blood Glucose and Lipids in Streptozotocin-Induced Diabetic Rats  

Lee, In-Seon (The Center for Traditional Microorganism Resources, Keimyung University)
Lee, Syng-Ook (The Center for Traditional Microorganism Resources, Keimyung University)
Lee, In-Za (Department of Pharmacology, Catholic University of Daegu)
Publication Information
Korean Journal of Food Science and Technology / v.35, no.2, 2003 , pp. 280-285 More about this Journal
Abstract
Hypoglycemic and hypolipidemic efficacies of cultured ginseng (CG) in streptozotocin (STZ)-induced diabetic rats were investigated. Male Sprague-Dawley rats were divided into normal and three diabetic groups. The diabetic groups were fed CG-free control diets supplemented with 5 and 10% of CG for 2 weeks. CG-supplemented groups showed significantly lower blood glucose, triglyceride, and total cholesterol content compared to the diabetic control group. CG supplementation at 5% significantly increased plasma high density lipoprotein (HDL)-cholesterol content compared to the diabetic control group. CG significantly increased plasma HDL-cholesterol/total cholesterol ratio and reduced atherogenic index, whereas, it did not affect plasma total lipid content in diabetic rats. The 5% CG reduced plasma AST and ALT activities in diabetic rats and inhibited the reduction of plasma creatinine level caused by STZ-treatment in rats. These data suggest that tissue-cultured ginseng has hypoglycemic, hypolipidemic, and anti-atherogenic effects on STZ-diabetic rats and can be useful as a dietary supplement for the treatment of diabetes.
Keywords
tissue cultured ginseng; hypoglycemic; hypolipidemic; streptozotocin;
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