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Antimutagenic Effect of Extract of Eleutherococcus senticosus Maxim  

Park, Jeong-Seob (Division of Bioscience and Biotechnology, Woosuk University)
Oh, Chan-Ho (Division of Bioscience and Biotechnology, Woosuk University)
Koh, Ha-Young (Division of Food Science and Nutrition, Woosuk University)
Choi, Dong-Seong (Division of Bioscience and Biotechnology, Woosuk University)
Publication Information
Korean Journal of Food Science and Technology / v.34, no.6, 2002 , pp. 1110-1114 More about this Journal
Abstract
Antimutagenic effect of Eleutherococcus senticosus Maxim. on the mutagenicity induced by 2-AF and Trp-P-1 was studied using the Ames test with Salmonella typhimurium TA98 and TA100. In S. typhimurium TA98, the methanol extract $(500\;{\mu}g/plate)$ of root, stem, and leaf of E. senticosus showed inhibitory effects of 72.8, 70.0, and 78.7% on the mutagenicity induced by 2-AF, and 69.2, 64.9, and 59.4% by Trp-P-1, respectively, whereas none was observed in S. typhimurium TA100. These results suggest that the methanol extract of E. senticosus inhibits a frame shift mutation. And then the methanol extract further fractionated by chloroform, butanol, and water. The chloroform fractions of root, stem, and leaf showed strong antimutagenic effects induced by 2-AF and Trp-P-1 in S. typhimurium TA98, whereas none was observed in the butanol and aqueous fractions. The chloroform fractions of root, stem, and leaf showed antimutagenic effects of $13{\sim]92%$ in a dose-dependent manner.
Keywords
Eleutherococcus senticosus; antimutagenicity; frame shift mutation; indirect mutagen;
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  • Reference
1 Ames, B.N. and Maron, D.M. Revised methods for the S. typhimurium mutagenicity test. Mutaion Res. 113: 173-215 (1983)   DOI
2 Bagg, A., Kenyon, C.J. and Walker, C. Inducibility of gene product required for UV and chemical mutagenesis in Escherichia coli. Proc. Natl. Acad. Sci. 78: 5749-5753 (1981)   DOI   ScienceOn
3 Ahn, B.Y., Kim, D.G. and Choi, D.S. Antimutagenic effect of Tansen (Salvia miltriorrhiza Bung). Korean J. Microbiol. Biotechnol.27: 197-202(1999)
4 Mohn, G.R. Bacterial systems for carcinogenicity testing. Mutation Res. 87: 191-210 (1981)   DOI   ScienceOn
5 Glatthaar-Saalmuller, B., Sacher, F. and Esperester, A. Antiviral activity of an extract derived from roots of Eleutherococcus senticosus. Antiviral Res. 50: 223-228 (2001)   DOI   ScienceOn
6 Brekhmann, I.I. and Dardymov, I.D. New substances of plant origin which increase nonspecific resistance. Ann. Rev. Phannacol. 9: 419-430 (1969)   DOI
7 Grimmer, H.R., Parbhoo, V. and McGrath, R.M. Antimutagenicity of polyphenol-rich fractions from Sorghum bicolor grain. J. Sci. Food Agric. 59: 251-256 (1992)   DOI
8 Szolomicki, S., Samochowiec, L., Wqjcicki, J. and Drozdzik, M. The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man. Phytotherapy Res. 14: 30-35 (2000)   DOI   ScienceOn
9 Yoon, B.T., Lee, S.W., Shin, K.S., Choi, W.H., Hwang, S.H., Seo, S.H., Kim, S.H. and Park, W.M. Effect of hot water extract from Acanthopanax senticosus on systemic anaphylaxis. Korean J Food Sci. Technol. 34: 518-523 (2002)
10 Hirata, F., Fugita, K., Ishikura, Y., Hosoda, K. and Ishikawa, H. Hypocholestrolemic effect of sesame lignan in humans. Atherosclerosis 122: 135-136 (1996)   DOI   ScienceOn
11 Salikhova, R.A., Umnova, N.V., Fomina, M.M. and Poroshenko, G.G. An antimutagenicity study of bioginseng. Izvestiia Akademii Nauk. Seriia Biologicheskaia 1: 48-55 (1994)
12 Kuroda, Y. and Inoue, T. Antimutagensis by factors affecting DNA repair in bacteria. Mutation Res. 202: 387-391 (1988)   DOI
13 Kao, K.B. Chinese Ciwujia Studies. Heilongjiang Institute of Traditional Chinese Medicine, Harbin, China (1981)
14 Danielak, R., Popowska, E. and Borkowski, B. The preparation of vegetable products containing isofraxidin, silibin, and Glaucium alkaloids and evaluation of their choloretic action, Polish J. Pharmacol. Pharma. 25: 271-283 (1973)   DOI
15 Hashimoto, Y., Shudo, K. and Okamoto, T. Activation of a mutagen, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indo1e. Identification of amino-1,4-dimethyl-5H-pyndo[4,3-b]indole and its reaction with DNA. Biochem. Biophys. Res. Commun. 96: 355-362 (1980)   DOI   ScienceOn
16 Strel'chuk, S.I. Antimutagemc effect of Eleutherococcus extracts on plants treated with ethylmethanesulfonate. Citol. Genet. 21: 136-139(1987)
17 Ong, T.M., Mukhtar, M., Wolf, C.R. and Zeiger., E. Differential effects of cytochrome P450-inducers on promutagen activation capabilities and enzymatic activities of S-9 from rat liver. J. Environ. Pathol. Toxicol. 4: 55-60 (1980)   PUBMED
18 Deyama, T., Nishibe, S. and Nakazawa, Y. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta Pharmacol. Sin. 22: 1057-1570 (2001)   PUBMED
19 Nishibe, S., Kinoshita, H., Takeda, H. and Okano, G. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Chem. Pharm. Bull. 38: 1763-1765( 1990)   DOI   PUBMED   ScienceOn
20 Song, G.S., Ahn, B.Y, Lee, G.S., Maeng, I.K. and Choi, D.S. Effect of hot water extracts from medicinal plants on the mutage nicity of indirect mutagens. Korean J. Food Sci. Technol. 29: 1288-1294 (1997)
21 Song, G.S., Ahn, B.Y., Maeng, I.K., Kwon, Y.J., Han, S.B. and Choi, D.S. Antimutageniccity screening of water extracts from chinese herbs with SOS Chromtest with several direct mutagens. Food Sci. Biotechnol. 6: 214-218 (1997)
22 Hacker, B. and Medon, PJ. Cytotoxic effects of Eleuthemcoccus senticosus aqueous extracts in combination with N-6-(de1ta-2-iso-pentenyl)-adenosine and 1-$\beta$-D-arabinofuranosyl cytosine against L1210 leukemia cells. J. Pharm. Sci. 73: 270-272 (1984)   DOI   PUBMED
23 Umnova, N.V., Michurina, T.L., Smimova, N.L., Aleksandrova, I.V., Poroshenko, G.G. Study of antimutagenic properties of bioginseng in mammalian cells in vitro and in vivo. Biulleten Ekspedmental Noi Biologii i Meditsiny 111: 507-509 (1991)
24 Kada, T., Morita, K. and Inoue, T. Anti-mutagenic action of vegetable factors on the mutagenic principle of tryptophan pyrolysate. Mutation Res. 53: 351-353 (1978)   DOI