Browse > Article

Effects of $H_2O$ Fraction of Alisma canaliculatum with Chromium on Blood Glucose Levels and Lipid Metabolism in Streptozotocin-Induced Diabetic Rats  

Lim, Sook-Ja (Department of Foods and Nutrition, College of Natural Sciences, Duksung Women's University)
Park, Ji-Eun (Department of Foods and Nutrition, College of Natural Sciences, Duksung Women's University)
Publication Information
Korean Journal of Food Science and Technology / v.34, no.4, 2002 , pp. 725-731 More about this Journal
Abstract
Hypoglycemic effects of $H_2O$ fraction of Alisma canaliculatum (Ac) with chromium (Cr) in streptozotocin (STZ)-induced diabetic rats were investigated. Sprague-Dawley rats were divided into five groups: normal, diabetic-control, and three diabetic experimental groups. Diabetes mellitus was induced by injection of STZ (45 mg/kg) into tail vein, and $H_2O$ fraction of Ac and Cr were administrated orally to experimental rats for 14 days: Ac group (1,000 mg/kg), Cr-Ac group (Ac 1,000 mg/kg & Cr 100 mg/kg), and Cr group (100 mg/kg). Body weight losses were observed in all groups except the normal group, while the losses in experimental groups were significantly less than in diabetic-control group. The plasma glucose levels were significantly lower in Cr, Ac-Cr, and Ac groups compared to STZ-control group. Plasma cholesterol and TG levels of Ac-Cr group were significantly lower than those of diabetic-control group. Plasma HDL-cholesterol levels of three experimental groups were not significant compared to diabetic-control group, while the level of Cr group decreased more than diabetic-control group. The results suggest that there was no synergistic effect in the treatment of $H_2O$ fraction of Ac in combination with Cr, an indication that $H_2O$ fraction of Ac with Cr might possess some hypoglycemic and hypotriglyceridemic properties in STZ-induced diabetic rats.
Keywords
Alisma canaliculatum; chromium; diabetes; glucose level; lipid level;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Annual Report on the Cause of Death Statistics. Korean Statistical Association, Seoul (1991)
2 Kim, T.H., Yang, K.S. and Whang, S.H. Studies on the physiochemical activities of Commelinae herba extract on the normaland the streptozotocininduced hyperglycemic rats. Thesis collec-tion. SM Pharm. Sci. 7: 39-59 (1990)
3 Science Encyclopedia Co. East medical science ed. A serise of Chinese herbal medicines of east medical science 15. Yeokang Co.,Seoul (1991)
4 Elias, A.N., Grossman, M.K and Valenta, L.J. Use of the artificial \beta cell (ABC) in the assessment of peripheral insulin sensitivity: Effect of chromium supplementation in diabetic patients. Gen. Pharmacol. 15: 535-539 (2000)
5 Sachiko, Y., Kunihiro, S., Ichiro, W. and Hidehisa, M. Effect of chromium administration in stroke-prone spontaneously hypertensive rats with streptozotocin-induced diabetes. Metabolism 41: 636-642(1992)   DOI   ScienceOn
6 Lee, S.S. and Kim, J.W. Pharmacological studies on the water extract of fractis of Lycium chinese Mill. Duksung Bull. Pharm. Sci. 2 : (1991)
7 Bauer, J.D. In clinical laboratory methods. 9th ed. pp. 188-189 Mosby Co., St. Louis, MO, USA (1982)
8 Giegel, J.L., Ham, S.B. and Clema, W. Serum triglyceride determined colorimetry with an enzyme that produces hydrogen peroxide. J. Clin. Chem. 21: 1575-1581 (1975)
9 Lee, J.S, Son, H.S., Maeng, Y.S., Chang, Y.K. and Ju JS. Effects of buckwheat on organ weight, glucose and lipid metabolism in streptozotocin-induced diabetic rats. Korean J. Nutr. 27: 819-827 (1994)
10 Sococher, M., Kunjara, S., Baquer, N.Z. and Mclean, P. Regulation of glucose metabolism in livers and kidneys of NOD mice. Diabetes 40: 1467-1471 (1991)   DOI   ScienceOn
11 Wannamethee, S.G., Perry, I.J. and Shaper, A.G. Hematocrit and risk of NIDDM. Diabetes 45: 576-579 (1996)   DOI   ScienceOn
12 Urano, S., Midori, H.H., Tochihi, N., Matsuo, M. and Ito, H. Vitamin E and the susceptibility of erythrocytes and reconstituted liposomes to oxidative stress in aged diabetics. Lipid 26: 58-61 (1991)   DOI   ScienceOn
13 Lim, S.S., Kim, M.H. and Lee, J.H. Effect of Artemisia Princeps var Orientalis and Circium japonicum var Ussuriense on liver function, body lipid, and bile acid of hyperlipidemic rat. Korean J.Nutr. 30: 797-802 (1997)
14 Reitman, S. and Frankel, S. A colonmetric method the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am. J. Clin. Pathol. 28: 58-63 (1957)
15 Preston, A.M., Tome, J., Morales, J.J., Milan, L., Cuevas, A.A., Medina, J. and Santiago, J.A. Diabetic parameters 58 weeks after injection with streptozotocin in rats fed basal diet supplemented with fiber, mineral and vitamins. Nutr. Res. 11: 895-906 (1991)   DOI   ScienceOn
16 Brooks, D.P., Nutting, T.F, Crofton, J.T. and Share, L. Vasopressin in rats with genetic and streptozotocin-induced diabetes. Diabetes 38: 54-57 (1989)   DOI   ScienceOn
17 Kim, M.H., Kim, H.Y., Kim, W.K., Kim, J.Y and Kim, S.H. Effects of soy oligosaccharides on blood glucose and lipid metabolism in streptozotocin-induced diabetic rats. Korean J. Nutr. 34: 3-13(2001)
18 Sohal, R.S. and Allen, R.G. Oxidative stress as a causal factor in differentiation and aging: A unifying hypothesis. Exp. Gerontol 25: 499-522 (1990)   DOI   ScienceOn
19 Choi, J.S., Chung, H.Y. and Han, S.Y. A preliniinary study on hypocholesterolemic and hypoglycemic activities of some medicinal plants. Korean J. Pharm. 21: (1990)
20 Junod, A., Lambert, A.E., Stauffacher, W. and Renold, A.E. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J. Clin. Invest. 48: 2129-2139 (1969)   DOI   PUBMED
21 Medical Laboratory Technology and Clinical Pathology. 2nd ed. WB Saunders Co., Philadelphia, PA, USA (1969)
22 Dai, S. and McNeill, J.H. One year treatment of non-diabetic and streptozotocin-diabetic rats with vanadyl sulphate did not alter blood pressure or haematological indices. Pharmacol. Toxicol. 74: 110-115(1994)   DOI   ScienceOn
23 Allain, C.C., Poon, L.S., Chan, C.S.G., Richmond, W. and Paul, C. Fu. Enzymatic determination of total serum cholesterol. J. Clin. Chem. 20: 470-475 (1974)
24 Lim, S.J., Kim, S.Y. and Lee, J.W. The effects of Korean wild vegetables on blood glucose levels and liver-muscle metabolism of streptozotocin-induced diabetic rats. Korean J. Nutr. 28: 585-594(1995)
25 Tai, E.S., Lim, S.C., Tan, B.Y., Chew, S.K., Heng, D. and Tan, C.E. Screening for diabetes mellitus: a two-step approach in individuals with impaired fasting glucose improves detection of those at risk of complications. Diabetes Med. 17: 771-775 (2000)   DOI   ScienceOn
26 Sexton, WL. Skeletal muscle vascular transport capacity in diabetic rats. Diabetes 43: 225-231 (1994)   DOI   PUBMED   ScienceOn
27 Nam, S.H, and Kang, M.Y. Screening of antioxidative activity of hot-water extracts from medical plants. J. Korean Soc. Agric. Chem. Biotechnol, 43: 141-147 (2000)
28 Lim, S.J. and Kim, S.H. The effect of each fraction of methanol extraction of Alisma canaliculatum on blood glucose levels and lipid metabolism in streptozotocin induced diabetic rats. Korean J. Nutr. 34: 619-625 (2001)
29 Anderson, R.A. Chromium, glucose intolerance and diabetes. J. Am. Coll. Nutr. 17: 548-555 (1998)   DOI   PUBMED
30 Mandarino, L.J. Current hypothesis for biochemical basis of retinopathy. Diabetes Care 15: 1892-1901 (1992)   DOI   PUBMED   ScienceOn
31 Kim, M.W., Park, M.H. and Kim, K.H. Effects of mushroom protein-bound polysaccharides on blood glucose levels and energy metabolism in streptozotocin-induced diabetic rats. Korean J. Nutr. 30: 743-750 (1997)
32 Jung, P.G. Vegetables of Herb Medicine. Hong Shin Co., Seoul (1994)
33 Reeves, P.G. Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr. 127: 838S-841S (1997)
34 Offenbacher, E.G. and Pi-Sunyer, F.X. Beneficial effects of chromium rich yeast on glucose tolerance and blood lipids in elderly subjects. Diabetes 29: 919-925 (1980)   DOI   ScienceOn
35 O'Meara, N.M.G, Devery, R.A.M., Owens, D., Collins, P.B., Johnson, A.H. and Tomkin, G.H. Cholesterol metabolism in alloxan-induced diabetic rabbits. Diabetes 39: 626-633 (1990)   DOI   ScienceOn
36 Nikkila, E.A. and Kekki, M. Plasma triglycende transport kinetics in diabetes mellitus. Metabolism 22: 1-22 (1973)   DOI   ScienceOn
37 Abrams, J.J., Ginberg, H. and Grundy, S.M. Metabolism of cholesterol and plasma triglycerides in non-ketotic diabetes mellitus. Diabetes 31: 903-910 (1982)   DOI   ScienceOn
38 Gold, G., Manning, M., Heldt, A., Nowlain, R., Pettit, J.G. and Grodsky, G.M. Diabetes induced with multiple subdiabetogenic doses of streptozotocin. Diabetes 30: 634-638 (1981)   DOI   ScienceOn
39 Pain, V.M. and Garlick, P. Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J. Biol. Chem. 249: 4510-4514 (1974)   PUBMED
40 Reddi, A.S. and Bollineni, J.S. Selenium-deficient diet renal oxidative stress and injury via TGF-beta 1 in normal and diabetic rats. Kidney Int. 59:1342-1353 (2001)   DOI   PUBMED   ScienceOn
41 Mertz, W. and Schwarz, K. Relationship of glucose tolerance factor to impaired glucose tolerance in rat diets. Am. J. Physiol. 196:614-618(1959)   PUBMED
42 Lim, S.J and Won, S.B. Effects of Korean wild vegetables on blood glucose levels and energy metabolites in streptozotocin induced diabetic rats. Korean J. Soc. Food Sci. 13: 639-647 (1997)
43 Guoyao, W.U. and Marliss, E.B. Enhanced glucose metabolism and respiratory burst in peritoneal macrophages from spontaneously diabetic BB rats. Diabetes 42: 520-529 (1993)   DOI   ScienceOn
44 Williamson, J.R., Chang, K., Frangos, M., Hasan, K.S., Ido, Y., Kawamura, Y., Nyengaard, J.R., Enden, M.V.D., Kilo, C. and Tilton, R.G. Perspectives in diabetes: hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42: 801-813 (1993)   DOI   ScienceOn
45 Rabbo, E. and Terkildsen, T.C. On the enzymatic determination of blood glucose. Scandinav. J. Lab. Invest. 12: 402-407 (1960)   DOI   ScienceOn
46 Finely, P.R., Schifman, R.B., Williams, R.J. and Luchti, D.A.Cholesterol in high density lipoprotem: use of Mg^2^+/dextran sulfate in its measurement. J. Clin. Chem. 24: 931-933 (1978)
47 Goldgerg, R.B. Lipid disorders in diabetes. Diabetes Care 4:(1981)
48 Rao, M., Blane, K. and Zonnenberg, M. PC-STAT. Dept. of Food Sci., Univ. Georgia, Athens, GA, USA (1985)
49 Richmond, W. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 19: 1350-1356 (1973)   PUBMED