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Effects of aerobic exercise training on acute inflanunatory markers and t-PA and cholesterol levels in obese men  

Yoo, Ho-Sang (영남대학교)
Park, Sung-Han (영남대학교)
Byun, Jae-Chul (영남대학교)
Publication Information
The Korean Journal of Physical Education / v.44, no.4, 2005 , pp. 325-335 More about this Journal
Abstract
C-reactive protein (CRP), fibrinogen, albumin, and white blood cell (WBC) counts were used as the markers for acute systemic inflammation CRP was significantly associated with obesity, high CRP level associated with increased cardiovascular disease risk. And generally, increased serum t-PA (tissue plasminogen activator) level is believed to reduce the risk of cardiovascular disease. Moreover, t-PA level may show to increase significantly after chronic exercise. The purpose of this study was to examine the effects of blood cholesterol and inflammatory markers and enhancement of systemic fibrinolytic activity after 8 weeks of aerobic exercise training. A total of 16 healthy males (n=8, control group) and obese males (n=8, experiment group) were served as subjects. Aged between 20_27 years. Subjects were assigned to a supervisor and given an exercise program 3 days a week. All subjects participated in an aerobic exercise training for 30 minutes, then did additional treadmill exercise for 30 minutes at which they were instructed to maintain a continuous 55% to 70% of the peak heart rate according to an initial exercise training. The present study showed that WBC count and serum Albumin level were no changes between groups. There were significantly different on plasma fibrinogen and serum CRP and t-PA levels between groups. Also, fibrinogen and CRP levels after aerobic exercise training were lower than pre exercise training in two groups, although serum t-PA level was e significant differences on TC level between pre and post exercise training in two groups, and HDL-C and LDL-C levels were shown to decreased. Aerobic exercise training may lowered CRP level, and there was enhanced t-PA level. In conclusion, regular physical activity may decrease the risk of cardiovascular diseases in both normal and obese men.
Keywords
TC; HDL-C; LDL-C; CRP; inflammatory markers; t-PA; aerobic exercise training;
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1 Barbeau, P., litaker, M.S., Woods, K F., Lemmon, C. R., Humphries, M. C., Owens,S., &Gutin, B. (2002). Hemostatic and inflammatory markers in obese youths: effects of exercise and adiposity. J Pediatr, 141(3), 415-420   DOI   ScienceOn
2 Bodary, P. F., Yausda, N., Watson, D. D., Brown, A.S., Davis, J. M. & Pate, R. R. (2003). Effects of short-term exercise training on plasminogen activator inhibitor (pAl-1). Med Sci Sports Exerc, 35:11, 1853-1858   DOI   ScienceOn
3 Bumiat, W., Cole, T. J., Lissau, I., Poskitt, E. M. E. (2002). Qrild and Adolescent obesity. UK: Cambridge University Press, 3-27, 221-239
4 Campfield, L. A., Smith, F. J. (1995). Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks? Science 269 (5223): 546-549   DOI   PUBMED
5 Eckel, R. H. (2003). Obesity-mechanisms and clinical management. USA: Lippincott Williams & Wilkins, 3-102
6 Jen-Chen, T., Wen-Yin, C., Ching-Chiu, K. (2002). Beneficial effect of on blood pressure and lipid profile by programmed exercise training in Taiwanese patients with mild hypertension. Clin Exper Hypertension, 24, 315-324.   DOI   ScienceOn
7 Sorichter, S., Koller, A., Haid, C. H., Wicke, K., Judrraier, W., Werner, P., & Raos, E. (1995). light concentric exercise and heavy eccentric muscle loading: effects of CK, MRI, and Markers of inflarmnation. Int J Sports Med, 16, 288-292   DOI   ScienceOn
8 Szymanski, L. M. & Pate, R. R. (1994). Fibrinolytic responses to moderate intensity exercise, comparision of physically active and inactive men. Thrombosis, 14, 1740-1750
9 최석준, 최태석, 이영진(2001). 10주간 달리기 운동이 비만여중생의 신체구성, 인슐린 및 렙틴 농도에 미치는 영향. 한국체육학회지, 제40권, 제2호, 759-768
10 황정숙, 이승훈, 박혜순(2003). 한국 성인 남성에서 CRP와 비만과의 연관성. 가정의학회지, 제24권, 58-63
11 Pischon, T., Hankinson, S. E., Hotamisligil, G. S., Rifai, N., & Rimrn, E. B. (2003). Leisure- time activity and reduced plasma levels of obesity-related inflammatory markers. Obes Res, 11(9), 1055-1064   DOI   ScienceOn
12 성은주, 신택수(2003). 한국 청소년비만이 심혈과질환 위험 인자에 미치는 영향. 가정의학회지, 제24권, 제11호, 1017-1025
13 Geffken, D. F., Cushman, M., Benett, M, Burke, G. L., Polak, J. F., Sakkinen, P. A., and Tracy, R. P. (1996). Association between physical activity and markers of inflammation in a healthy elderly population Am J Epidemiol., 183-187
14 Visser, M., Bouter, L. M., McWuillan, G. M., Wender, M. H., & Harris, T. B. (2001). Low-grade systemic inflammation in overweight children. Pediatrics, 107(1): E13   DOI   ScienceOn
15 김남익(2004). 고도 비만 여성들의 저항성 운동을 병행한 유산소운동프로그램이 신체조성 및 심전도 반응에 미치는 영향. 한국체육학회지, 제43권, 제3호, 633-644
16 Abramson, J. L., and Vaccarino, V. (2002). Relationship between physical activity and inflammation among apparently healthy middle-aged and older US adults. Arch Intern. Med., 162, 1286-1292   DOI   ScienceOn
17 DeSouza, C. A., Shapiro, L. F., Oevenger, C. M., Dinenno, F. A., Monahan, K D., Tanaka, H. & Seals, D. R. (2000). Regular aerobic exercise prevents and restores the age-related decline in endothelium- dependent vasodilation in healthy men. Circulation, 102, 1351-1357   DOI   ScienceOn
18 Upton, S. J., Hagan, R. D., & Joel, R. D. (1984). Comparative physiological profiles among young and middle-aged female distance runners. Med Sci Sports Exerc, 16(1), 67-71
19 변재철(2003). 점진적 최대부하 운동이 마라톤 동호인의 WBC와 C-reactie protein 농도에 미치는 영향. 대한스포츠의학회지, 제22권, 제2호, 119-126
20 MacAuley, D., McCrum, E. E., and Stott, G. (1996). Physical activity, physical fitness, blood pressure, and fibrinogen in the Northern Island health and activity survey. J Epidemiol Comrnunity Health. 50, 258-263   DOI   ScienceOn
21 Monkgomery, H. E., Clarkson, P., and Nwose, O. M. (1996). The acute rise in plasma fibrinogen concentration with exercise is influenced by the G453. A polymorphism of the beta fibrinogen gene. Atherscler. Thromb. Vase. Biol., 16, 386-391   DOI   ScienceOn
22 김남익, 윤상호(2002). C-reactive protein (CRP) 농도가 고령자들의 안정시 및 운동부하 검사시 심장혈관계 질환 위험 요소에 미치는 영향. 제40회 한국체육학회 학술발표회, 629-636
23 Katzmarzyk, P. T., Leon, A.S., Rankinen, T., Gagnon, J., Skinner, J. S., WIlmore, J. H., Rao, D. C. & Bouchard, C. (2001). Changes in blood pressure in blood pressure consequent to aerobic exercise training related to changes in body fatness and aerobic fitness. Metabolism, 50(7), 841-848   DOI   ScienceOn
24 KNHE: Korea Health Examination survey. 1998. In pres 2000
25 Pascual, M., Pascual, D. A., Soria, F., & Vicente, T. (2003). Effects of isolated obesity on systolic and diastolic left ventricular function. Heart. 89(10), 1152   DOI   PUBMED
26 Sprengers, E. D. & Kluft, C. (1987). Plasminogen activator inhibitor. Blood, 69, 381
27 ACSM (1995). ACSM's guidelines for exercise testing and prescription. 5th ed. Philadelphia, lippincott Williams and WIlkins
28 Jerome, L. Abramson, & Vaccarino, V. (2002). Relationship between physical activity and inflammation among apparently healthy middle- aged and older US adults. Arch Int Med, 162, 1286-1292   DOI   ScienceOn
29 Lakka, T. A. & Salonen, J. K. (1993). Moderate to high intensity conditioning leisure time physical activity and high cardiorespiratory fitness are associated with reduced plasma fibrinogen in eastern Finnish men. J Clin Epidemiol, 46, 1196-1927
30 Hirura, M., Kikuchi, T., Nagasaki, K., & Uchiyama, M. (2003). Hypertens Res, 26(7), 541-546   DOI   ScienceOn
31 Saito, I., Yonemasu, K., & Inami, F. (2003). Association of body mass index, body fat, and weight gain with inflammation markers among rural residents in Japan. Circ J, 67(4), 323-329   DOI   ScienceOn
32 Smith, D. T., Hoetzer, G. L., Greiner, J. J., Stauffer, B. L. &DeSouza, C. A. (2003). Effects of ageing and regular aerobic exercise on endothelial fibrinolytic capacity in humans. J Physiol, 1: 546, 289-298
33 왕석우(2004). 비만유전자 변이 유, 무에 따른 12주간의 운동이 대사조절호르몬, 혈중 지질, 신체구성에 미치는 영향, 한국체육학회지, 제43권, 제3호, 699-711
34 최희남(1992). 유산소 운동이 중년여성의 혈청지질, 체지방, 근력 및 심폐기능에 미치는 효과. 세종대학교 대학원 박사학위논문
35 Bullo, M., Garcia-Lorda, P., Megias, I., & SalasSalvado, J. (2003). Systemic inflammation, adipose tissue tumor necrosis factors, and leptin expression. Obes Res, 11(4), 525-531   DOI
36 Croisier, J. L., Camus, G., Venneman, I., Deby-Dupont, G., Juchmes-Ferir, A., lamy, M., Crielaard, J. M., Devy, C., & Duchateau, J. (1999). Effects of training on exercise-induced muscle damage and interleukin-6 production. Muscle & Nerve, 208-212
37 변재철(2004). 점진적 최대부하 운동이 혈중 급성염증인자와 섬유소 용해능에 미치는 영향. 한국체육학회지, 제43권, 제6호, 429-439
38 Ridker, P. M., Burning. J. E., Shih, J., Matias, M., Hennekens, C. H. (1998). Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women. Circulation, 98, 731-733   DOI   ScienceOn
39 Sunyer, F. X. (1993). Medical hazards of obesity. Ann Intern Med, 119, 655-660   DOI   ScienceOn
40 이정윤, 박병근, 김광중(2004). 12주 규칙적인 에어로빅 트레이닝이 중년비만여성의 급성기염증 단백질 및 관상동맥질환위험인자에 미치는 영향. 한국체육학회지, 제43권, 제5호, 301-309
41 김병로, 이동식(2001). 저탄수화물 식이요법과 유산소 운동이 중학교 비만학생의 체중과 혈중 지질에 미치는 영향. 한국체육학회지, 제40권, 제2호, 579-589
42 Jequier, E., Tappy, L. (1999). Regulation of body weight in humans? Physiol Rev, 79(2), 51-480
43 장현용, 홍상완, 김봉석, 강호율(2003). 6주간의 유산소성 운동이 비만 청소년의 중 Leptin 수준에 미치는 영향. 한국체육교육학회지, 제8권, 제3호, 125-134
44 탁양주, 이영성, 이진석, 강재헌(2004). 최근 국내 비만 연구의 경향: 1984년부터 2002년까지. 대한비만학회지, 제13권, 제1호, 1-13