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http://dx.doi.org/10.3339/jkspn.2013.17.1.6

Pathology of Thrombotic Microangiopathy  

Sol, Mee Young (Department of Pathology, Pusan National University Yangsan Hospital)
Publication Information
Childhood Kidney Diseases / v.17, no.1, 2013 , pp. 6-12 More about this Journal
Abstract
Thrombotic microangiopathy (TMA) is a microvascular thrombotic lesion caused by endothelial injury and subsequent formation of platelet rich thrombus. TMA is first described as a classical pathologic feature of HUS/TTP. Renal biopsy finding of TMA represents kidney involvement of HUS/TTP as well as other diseases such as malignant hypertension, drug toxicity, eclampsia, pre-eclampsia, and several systemic infections. Autoimmune diseases and transplant kidney sometime also have TMA. It is needed to consider a complete autoimmune work-up of patients presenting with TMA including tests for ANA, ANCA, and ADAMTS13 inhibitory antibodies, because there are several reports of association with TMA in patients of SLE, anti-phospholipid syndrome, and ANCA-associated vasculitis.
Keywords
Thrombotic microangiopathy; Renal biopsy;
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