Browse > Article
http://dx.doi.org/10.3339/jkspn.2011.15.2.146

Urinary Calcium Excretion in Children with Primary Monosymptomatic Nocturnal Enuresis  

Chung, Woo-Yeong (Department of Pediatrics, Busan Paik Hospital, College of Medicine, Inje University)
Cho, Min-Hyun (Department of Pediatrics, Kyungpook National University School of Medicine)
Park, Yong-Hoon (Department of Pediatrics, Yeung Nam University, College of Medicine)
Publication Information
Childhood Kidney Diseases / v.15, no.2, 2011 , pp. 146-153 More about this Journal
Abstract
Purpose : Hypercalciuria has been suggested to be involved in the pathogenesis of nocturnal enuresis associated with polyuria. We have measured the amount of calcium excretion in the urine from children with monosymptomatic nocturnal enuresis and studied the association with enuresis. Methods : Thirty-six children (20 males and 16 females, age 5 to 15.6 years) presenting with monosymptomatic nocturnal enuresis were recruited for this study. Results : Among 36 patients, 6 patients had hypercalciuria, providing a 16.7% frequency. The mean Ca/Cr ratio of hypercalciuria group showed $0.23{\pm}0.10$ on daytime, and $0.33{\pm}0.10$ on nighttime showing higher values in nighttime, but it was not statistically significant. Average 24 hour calcium excretion was 8.95 mg/kg. Night/day time urine volume ratio in hypercalciuria group was $0.87{\pm}0.20$, and that in normocalciuria group was $0.81{\pm}0.33$, also showing no difference. Daytime Ca/Cr ratio and nighttime Ca/Cr ratio from all enuresis patients showed a significant correlation (P=0.0001). However, Ca/Cr ratio between daytime and nighttime urine volume had no significant correlation, respectively (daytime P=0.08; nighttime P=0.07). Also, daytime and nighttime Na concentration, urea concentration, and osmolality also had no significant correlation with urine Ca/Cr ratio, respectively. Conclusion: Hypercalciuria shown in some of enuresis patients is not directly caused by primary monosymptomatic nocturnal enuresis.
Keywords
Children; Primary monosymptomatic nocturnal enuresis; Hypercalciuria;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Norgaard JP, Djurhuus JC, Watanabe H, Stenberg A, Lettgen B. Experience and current status of research into the pathophysiology of nocturnal enuresis. Br J Urol 1997;79:825-35.   DOI
2 Eggert P, Muller-Schluter K, Muller D. Regulation of arginine vasopressin in enuretic children under fluid restriction. Pediatrics 1999;103:452-5.   DOI   ScienceOn
3 Pace G, Aceto G, Cormio L, Traficante A, Tempesta A, Lospalluti ML et al. Nocturnal enuresis can be caused by absorptive hypercalciuria. Scan J Urol Nephrol 1999;33:111-4.   DOI   ScienceOn
4 Kamperis K, Hagstroem S, Riittig S, Djurhuus JC. Urinary calcium excretion in healthy children and children with primary monosymptomatic nocturnal enuresis. J Urol 2006;176:770-3.   DOI   ScienceOn
5 Raes A, Dehoorne J, Hoebeke P, Van Laecke E, Donckerwolcke R, Walle JV. Abnormal circulatin rhythm or nocturnal polyuria in a subgroup of children with enuresis and hypercalciuria is related to increased sodium retention during daytime. J Urol 2006;176:1147-51.   DOI   ScienceOn
6 Kuznetsova AA, Shakhmatova El, Prutskova NP, Natochin YV. Possible role of prostaglandins in pathogenesis of nocturnal enuresis in children. Scan J Urol Nephrol 2000;34:27-31.   DOI   ScienceOn
7 Husmann DA. Enuresis. Urology 1996;48:184-93.   DOI   ScienceOn
8 Mark SD, Frank JD. Nocturnal enuresis. Br J Urol 1995;75:427-34.   DOI   ScienceOn
9 Dehoorne JL, Raes AM, van Laecke E, Hoebeke P, Vande Walle JG. Desmopressin resistant nocturnal polyuria secondary to increased nocturnal osmotic excretion. J Urol 2006;176:749-53.   DOI   ScienceOn
10 Kuznetsova AA, Natochin YV, Papayan AV. Osmoregulatory fuction of the kidney in enuretic children. Scan J Urol Nephrol 1998;32:132-7.   DOI   ScienceOn
11 Raes A, Dossche L, Hertegonne N, Nuytemans, Hoebeke P, van Laecke E et al. Hypercalciuria is related to osmolar execretion in children with nocturnal enuresis. J Urol 2010;183:297-301.   DOI   ScienceOn
12 Neveus T, Hansell P, Stenberg A. Vasopressin and hypercalciuria in enuresis: a reappraisal. BJU Int 2002;90:725-9.   DOI   ScienceOn
13 Aceto G, Penza R, Delvecchio M, Chiozza ML, Cimador M, Caione P. Sodium fraction excretion rate in nocturnal enuresis correlates with nocturnal polyuria and osmolality. J Uro 2004;171:2567-70.   DOI   ScienceOn
14 Vezzoli G, Soldati L, Gambaro G. Update on primary hypercalciuria from a genetic perspective. J Urol 2008;179:1676-82.   DOI   ScienceOn
15 Valenti G, Laera A, Pace G, Aceto G, Lospalluti L, Penza R et al. Urinary aquaporin 2 and calaiuria corelate with the severity of enuresis in children. J Am Soc Nephrol 2000;11:1873-81.
16 Kamperis K, Hansen MN, Hagstroem S, Hvistendahl G, Djurhuus JC, Rittig S. The circadian rhythm of urine production, and urinary vasopressin and prostaglandin E2 excretion in healthy children. J Urol 2004;171:2571-5.   DOI   ScienceOn
17 Norgaard JP, Rittig S, Djurhuus JC. Nocturnal enuresis: an approach to treatment based on pathogenesis. J Pediatr 1989;114:705-10.   DOI
18 Rittig S, Knudsen UB, Norgaard JP, Pedersen EB, Djurhuus JC. Abnormal diurnal rhythm of plasma vasopressin and urinary output in patients with enuresis. Am J Physiol 1989;256:F664-71.
19 Hjalmas K, Arnold K, Bower W, Caione P, Chiozza LM, von Gontard A et al. Nocturnal enuresis: an international evidence based management strategy. J Urol 2004;171:2545-61.   DOI   ScienceOn
20 Yeung CK. Nocturnal enuresis(bedwetting). Curr Opin Urol 2003;13:337-43.   DOI   ScienceOn