Browse > Article
http://dx.doi.org/10.3339/jkspn.2011.15.1.49

Clinical Patterns of Acute Poststreptococcal Glomerulonephritis: A Single Center's Experience  

Yu, Ri-Ta (Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital)
Park, Se-Jin (Department of Pediatrics, Ajou University School of Medicine, Ajou University Hospital)
Shin, Jae-Il (Department of Pediatrics, Yonsei University College of Medicine, Severance Children's Hospital)
Kim, Kee-Hyuck (Department of Pediatrics, National Health Insurance Corporation Ilsan Hospital)
Publication Information
Childhood Kidney Diseases / v.15, no.1, 2011 , pp. 49-57 More about this Journal
Abstract
Purpose: The aim of this study is to investigate the change in incidence and clinical characteristics of acute poststreptococcal glomerulonephritis (APSGN) through a single center's experience. Methods: We retrospectively analyzed the medical records of 53 children who were diagnosed with glomerular nephritis at National Health Insurance Corporation Ilsan Hospital between March 2000 and December 2009. Twenty-six of 53 patients falled to meet the dragnostic criteria of APSGN and were excluded. Chief complaints, physical examinations, urinalysis, urine culture, laboratory results, chest x-ray, and clinical manifestations were all retrieved from the remaining 27 patients. Results: The incidence of APSGN by age was highest in children between six to seven years of age, with similar distributions in both genders, and seasonal incidence was higher from November to February when compared to other months, which was similar to the previously reported studies. However, the annual number of APSGN patients did not show a significant decrease from 2000 to 2009. The incidences of edema and hypertension were 59.3% and 48.1% respectively, suggesting lower incidences than those from previous studies. Six patients (22.2%) experienced hematuria for more than 6 months. Hypertensive encephalopathy, one of APSGN critical complications occurred in one patient but resolved with conservative treatment. Conclusion: Our study shows that APSGN still occur as a common renal disease but the disease severity seems to decrease with milder clinical manifestations and less complications compared to past studies.
Keywords
Acute Poststreptococcal Glomerulonephritis; Anti-streptolysin O; C3;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
연도 인용수 순위
1 Choi BH, Chu MA, Hong EH, Hwang HH. Cho MH, Ko CW. Changes of clinical findings of acute poststreptococcal glomerulonephritis. J Korean Soc Pediatr Nephrol 2008;12:157- 63.   DOI
2 Dodge WF, Spargo BH, Travis LB, Srivastava RN, Carvajal HF, DeBeukelaer MM, et al. Poststreptococcal glomerulonephritis. N Engl J Med 1972;286:273-8.   DOI   ScienceOn
3 Kim CH, Kim SY. Comparison between pathologically and clinically diagnosed group of acute postinfectious glomerulonephritis. Korean J Pediatr 1999;42:1696-701.
4 Kasahara T, Hayakana H, Okubo S, Okugawa T, Kabuki N, Tomizawa S, et al. Prognosis of acute poststreptococcal glomerulonephritis is excellent in children, when adequately diagnosed. Pediatr Int 2001;43: 463-7.
5 Dodge WF. Spargo BH. Travis LB. Srivastava RN, Carvajal HF. DeBeukelaer MM, Longley MP. Mechaca JA: Poststreptococcal glomerulonephritis: A prospective study in children. N Engl J Med 1972;286:273-8.   DOI   ScienceOn
6 Burke EC, Titus JL. Poststreptococcal acute glomerulonephritis in children. Med Clin North Am 1996;50:1141-58.
7 Potter EV, Abidh S, Sharrett AR, Burt EG, Svartman M, Finklea JF, et al. Clinical healing two to six years after poststreptococcal glomerulonephritis in Trinidad. N Eng J Med 1978;298:767-72.   DOI   ScienceOn
8 Bernstein SH, Stillerman M. A study of the association of group A streptococci with acute glomerulonephritis. Ann Int Med 1960;52:106-34.
9 Davis ID, Avner ED. Glomerulonephritis associated with infection. In: Behman RE, Kliegman RM, Jenson MB, editors. Nelson's textbook of Pediatrics. 17th ed. Philadelphia: W.B. Saunders Co, 2003:1740-1.
10 Nissenson AR, Mayon-White R, Potter EV, Mayon-White V, Abidh S, Poon-King T, et al. Continued absence of clinical renal disease seven to twelve years after poststreptococcal acute glomerulonephritis in Trinidad. Am J Med 1979;67:255-62.   DOI   ScienceOn
11 Chang SK, Lee JS, Oh SH, Park HJ, Kim PK. A clinical study on 452 cases of poststreptococcal acute glomerulonephritis in children. Korean J Nephr 1987;6:295-303.
12 Koo SE, Hahn H, Park YS. A clinical study of acute poststreptococcal glomerulonephritis in children, from 1994 to 2003. Korean J Pediatr 2005;48:606-13.
13 Baldwin DS, Gluck MC, Schacht RG, Gallo GR. The long-term course of poststreptococcal glomerulonephritis. Ann Intern Med 1974;80:342-58.   DOI   ScienceOn
14 Coppo R, Gianoglio B, Porcellini MG, Maringhini S. Frequency of renal diseases and clinical indications for renal biopsies in children: Report of the Italian National registry of Renal Biopsies in Children). Nephrol Dial Transplant 1998;13:293-297.   DOI   ScienceOn
15 Rodriguez-Iturbe B, Batsford S. Pathogenesis of poststreptococcal glomerulonephritis: a century after Clemens von Pirquet. Kidney Int 2007;71:1094-104.   DOI   ScienceOn
16 Currie B, Brewster DR. Childhood infections in the tropical north of Australia. J Paediatr Child Health 2001;37:326-30.   DOI   ScienceOn
17 Orta N, Moriyo'n JC. Epidemiology of renal diseases in children in Venezuela. Arch Venez Puericult Pediatr 2001;64:76-83.
18 Song YK, Kim CK, Lee YI. Statistical studies on acute glomerulonephritis in children. J Korean Pediatr Soc 1969;12:423-30.
19 Ahn SY, Ingulli E. Acute poststreptococcal glomerulonephritis : An update. Curr Opin Pediatr 2008;20:157-62.   DOI   ScienceOn
20 Bai SK, Cheun SJ, Kim PK, Yun DJ. Clinical follow-up studies on acute glomerulonephritis 220 cases. J Korean Pediatr Soc 1973;16:305-13.
21 Koo JH, Cho NK, Lee SB. Clinical studies on 123 cases of acute glomerulonephritis in children. Kyungpook Univ Med J 1977;18: 279-86.
22 Berrios X, Lagomarsino E, Solar E, Sandoval G, Guzman B, Riedel I. Post-streptococcal acute glomerulonephritis in Chile- 20 years of experience. Pediatr Nephrol 2004;19: 306-12.   DOI   ScienceOn
23 Kim YJ, Kim SJ. Resurgence of poststreptococcal acute glomerulonephritis in Chinju : clinical review of recent 10 years. Korean J Infect Dis 1998;30:516-20.
24 Hahn H. Acute renal failure in pediatrics. Korean J Pediatr 2007;50:949-53.
25 Bellomo R, Kellum JA, Mehta R, Palevsky PM, Ronco C. The Acute Dialysis Quality Initiative II: the Vicenza conference. Adv Ren Replace Ther 2002;9:290-3.   DOI   ScienceOn
26 Kim JO, Shin SM, Park YH. A clinical study on children with acute glomerulonephritis. Korean J Pediatr 1989;32:779-88.
27 Pinto SW, Sesso R, Vasconcelos E, Watanabe YJ, Pansute AM. Follow-up of patients with epidemic poststreptococcal glomerulonephritis Am J Kidney Dis 2001;38:249-55.   DOI   ScienceOn
28 Clark G, White R, Glasgow EF, Chantler C, Cameron JS, Gill D, et al. Poststreptococcal glomerulonephritis in children: Clinicopathological correlations and long-term prognosis. Pediatr Nephrol 1988;2:381-8.   DOI   ScienceOn
29 Schwartz B, Facklan RR, Breiman RF. Changing epidemiology of group A streptococcal infection in the USA. Lancet 1990;336: 1167-71.   DOI   ScienceOn
30 Kaplan EL, Hill HR. Return of rheumatic fever: Consequences, implications, and needs. J Pediatr 1987;111:244-6.   DOI
31 Potter EV, Lipschultz SA, Abidh S, Poon King T, Earle DP. Twelve to seventeenyear follow up of patients with poststreptococcal acute glomerulonephritis in Trinidad. N Engl J Med 1982;16:725-9.