Browse > Article
http://dx.doi.org/10.3339/jkspn.2010.14.1.51

Association Study between CCL-2 and CCL-5 Polymorphisms and Clinicopathological Characteristics of Childhood IgA Nephropathy  

Hahn, Won-Ho (Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University)
Suh, Jin-Soon (Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University)
Cho, Byoung-Soo (Department of Pediatrics, School of Medicine East West Kidney Diseases Research Institute Kyung Hee University)
Publication Information
Childhood Kidney Diseases / v.14, no.1, 2010 , pp. 51-61 More about this Journal
Abstract
Purpose : Previous studies have suggested that Chemokine (C-C motif) ligand-2 (CCL-2; also known as MCP-1) and CCL-5 (also known as RANTES) are possibly associated with the pathogenesis of various inflammatory and non-inflammatory renal diseases. The present study was conducted to investigate association of polymorphisms of CCL-2 and CCL-5 genes with childhood IgA nephropathy (IgAN). Methods : The authors analyzed six single nucleotide polymorphisms (SNPs) of CCL-2 and CCL-5 in 196 pediatric IgAN patients and in 285 healthy controls. We compared variations in SNPs between two several sets of IgAN subgroups, allocated by presence of proteinuria (>4 mg/$m^2$/hour), podocyte foot process effacement, and pathologically advanced disease markers, such as interstitial fibrosis, tubular atrophy, or global sclerosis. Results : Genotypic data of IgAN patients and controls showed no significant SNP frequency difference in both of of CCL-2 and CCL-5. Even though two linkage disequilibrium blocks were formed, there was no significance in the haplotype analysis. In the patient subgroup analysis, no SNP of CCL-2 and CCL-5 was found to be associated with the presence of proteinuria, podocyte foot process effacement, and pathologically advanced disease markers. Conclusion : Our data indicate that no association exists between CCL-2 and CCL-5 SNPs and childhood IgAN susceptibility, and presence of proteinuria, podocyte foot process effacement, and pathologic progression of IgAN.
Keywords
CCL-2; MCP-1; CCL-5; RANTES; Chemokine; Polymorphism; IgA nephropathy; Childhood;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Wolf G, Ziyadeh FN, Thaiss F, Tomaszewski J, Caron RJ, Wenzel U, et al. Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor. J Clin Invest 1997;100:1047-58.   DOI   ScienceOn
2 Moon JY, Jeong L, Lee S, Jeong K, Lee T, Ihm CG, et al. Association of polymorphisms in monocyte chemoattractant protein-1 promoter with diabetic kidney failure in Korean patients with type 2 diabetes mellitus J Korean Med Sci 2007;22:810-4.   DOI   ScienceOn
3 Mori H, Kaneko Y, Narita I, Goto S, Saito N, Kondo D, et al. Monocyte chemoattractant protein-1 A-2518G gene polymorphism and renal survival of Japanese patients with immunoglobulin A nephropathy. Clin Exp Nephrol 2005;9:297-303.   DOI   ScienceOn
4 Ye DQ, Yang SG, Li XP, Hu YS, Yin J, Zhang GQ, et al. Polymorphisms in the promoter region of RANTES in Han Chinese and their relationship with systemic lupus erythematosus. Arch Dermatol Res 2005;297:108-13.   DOI   ScienceOn
5 Kim HL, Lee DS, Yang SH, Lim CS, Chung JH, Kim S, et al. The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE. Am J Kidney Dis 2002;40:1146-52.   DOI   ScienceOn
6 Maruyama K, Yoshida M, Nishio H, Shirakawa T, Kawamura T, Tanaka R, et al. Polymorphisms of renin-angiotensin system genes in childhood IgA nephropathy. Pediatr Nephrol 2001;16:350-5.   DOI   ScienceOn
7 Brabcova I, Petrasek J, Hribova P, Hyklova K, Bartosova K, Lacha J, et al. Genetic variability of major inflammatory mediators has no impact on the outcome of kidney transplantation. Transplantation 2007;84: 1037-44.   DOI   ScienceOn
8 Nakanishi K, Sako M, Yata N, Aoyagi N, Nozu K, Tanaka R, et al. A-20C angiotensinogen gene polymorphism and proteinuria in childhood IgA nephropathy. Pediatr Nephrol 2004;19:144-7.   DOI   ScienceOn
9 Mlynarski WM, Placha GP, Wolkow PP, Bochenski JP, Warram JH, Krolewski AS. Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sexspecific effect. Diabetes 2005;54:3331-5.   DOI   ScienceOn
10 Malafronte P, Vieira JM, Jr., Pereira AC, Krieger JE, Barros RT, Woronik V. Association of the MCP-1 -2518 A/G Polymorphism and No Association of Its Receptor CCR2 -64 V/I Polymorphism with Lupus Nephritis. J Rheumatol 2010;37:776-8.   DOI   ScienceOn
11 Nakashima H, Akahoshi M, Shimizu S, Inoue Y, Miyake K, Ninomiya I, et al. Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. Lupus 2004;13:165-7.   DOI   ScienceOn
12 Das L, Brunner HI. Biomarkers for renal disease in childhood. Curr Rheumatol Rep 2009;11:218-25.   DOI   ScienceOn
13 Steinmetz OM, Panzer U, Harendza S, Mertens PR, Ostendorf T, Floege J, et al. No association of the -2518 MCP-1 A/G promoter polymorphism with incidence and clinical course of IgA nephropathy. Nephrol Dial Transplant 2004;19:596-601.   DOI
14 Lee HS, Lee MS, Lee SM, Lee SY, Lee ES, Lee EY, et al. Histological grading of IgA nephropathy predicting renal outcome: revisiting H. S. Lee's glomerular grading system. Nephrol Dial Transplant 2005;20: 342-8.   DOI
15 Sole X, Guino E, Valls J, Iniesta R, Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics 2006;22: 1928-9.   DOI   ScienceOn
16 Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. The structure of haplotype blocks in the human genome. Science 2002;296:2225-9.   DOI   ScienceOn
17 Dantas M, Romao EA, Costa RS, dos Reis MA, Vieira Neto OM, Ribeiro RA, et al. Urinary excretion of monocyte chemoattractant protein-1: a biomarker of active tubulointerstitial damage in patients with glomerulopathies. Kidney Blood Press Res 2007;30:306-13.   DOI   ScienceOn
18 Tucci M, Barnes EV, Sobel ES, Croker BP, Segal MS, Reeves WH, et al. Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis. Arthritis Rheum 2004;50:1842-9.   DOI   ScienceOn
19 Tesch GH. MCP-1/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am J Physiol Renal Physiol 2008;294:F697-701.   DOI   ScienceOn
20 Yao TC, Kuo ML, See LC, Ou LS, Lee WI, Chan CK, et al. RANTES and monocyte chemoattractant protein 1 as sensitive markers of disease activity in patients with juvenile rheumatoid arthritis: a six-year longitudinal study. Arthritis Rheum 2006; 54:2585-93.   DOI   ScienceOn
21 Mokubo A, Tanaka Y, Nakajima K, Watada H, Hirose T, Kawasumi M, et al. Chemotactic cytokine receptor 5 (CCR5) gene promoter polymorphism (59029A/G) is associated with diabetic nephropathy in Japanese patients with type 2 diabetes: a 10-year longitudinal study. Diabetes Res Clin Pract 2006;73:89-94.   DOI   ScienceOn
22 Nakajima K, Tanaka Y, Nomiyama T, Ogihara T, Ikeda F, Kanno R, et al. RANTES promoter genotype is associated with diabetic nephropathy in type 2 diabetic subjects. Diabetes Care 2003;26:892-8.   DOI   ScienceOn
23 Song E, Zou H, Yao Y, Proudfoot A, Antus B, Liu S, et al. Early application of Met- RANTES ameliorates chronic allograft nephropathy. Kidney Int 2002;61:676-85.   DOI   ScienceOn
24 Joo KW, Hwang YH, Kim JH, Oh KH, Kim H, Shin HD, et al. MCP-1 and RANTES polymorphisms in Korean diabetic endstage renal disease. J Korean Med Sci 2007;22:611-5.   DOI   ScienceOn
25 Prasad P, Tiwari AK, Kumar KM, Ammini AC, Gupta A, Gupta R, et al. Association of TGFbeta1, TNFalpha, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian Indians. BMC Med Genet 2007;8:20.
26 Brown KS, Nackos E, Morthala S, Jensen LE, Whitehead AS, Von Feldt JM. Monocyte chemoattractant protein-1: plasma concentrations and A(-2518)G promoter polymorphism of its gene in systemic lupus erythematosus. J Rheumatol 2007;34:740-6.
27 Ahluwalia TS, Khullar M, Ahuja M, Kohli HS, Bhansali A, Mohan V, et al. Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians. PLoS One 2009;4:e5168.   DOI
28 Aguilar F, Gonzalez-Escribano MF, Sanchez-Roman J, Nunez-Roldan A. MCP-1 promoter polymorphism in Spanish patients with systemic lupus erythematosus. Tissue Antigens 2001;58:335-8.   DOI   ScienceOn
29 Tian S, Li J, Wang L, Liu T, Liu H, Cheng G, et al. Urinary levels of RANTES and MCSF are predictors of lupus nephritis flare. Inflamm Res 2007;56:304-10.   DOI   ScienceOn
30 Furuichi K, Wada T, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, et al. Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases. Am J Nephrol 2000;20:291-9.   DOI   ScienceOn
31 Chan RW, Lai FM, Li EK, Tam LS, Chow KM, Li PK, et al. Messenger RNA expression of RANTES in the urinary sediment of patients with lupus nephritis. Nephrology (Carlton) 2006;11:219-25.   DOI   ScienceOn
32 Vielhauer V, Berning E, Eis V, Kretzler M, Segerer S, Strutz F, et al. CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome. Kidney Int 2004;66:2264-78.   DOI   ScienceOn
33 Wada T, Yokoyama H, Furuichi K, Kobayashi KI, Harada K, Naruto M, et al. Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). FASEB J 1996;10:1418-25.   DOI
34 Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ, et al. RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med 1997;185: 1371-80.   DOI   ScienceOn
35 Stangou M, Alexopoulos E, Papagianni A, Pantzaki A, Bantis C, Dovas S, et al. Urinary levels of epidermal growth factor, interleukin-6 and monocyte chemoattractant protein- 1 may act as predictor markers of renal function outcome in immunoglobulin A nephropathy. Nephrology (Carlton) 2009; 14:613-20.   DOI   ScienceOn
36 Wagrowska-Danilewicz M, Danilewicz M, Stasikowska O. CC chemokines and chemokine receptors in IgA nephropathy (IgAN) and in non-IgA mesangial proliferative glomerulonephritis (MesProGN). the immunohistochemical comparative study. Pol J Pathol 2005;56:121-6.
37 Cheng J, Diaz Encarnacion MM, Warner GM, Gray CE, Nath KA, Grande JP. TGF-beta1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process. Am J Physiol Cell Physiol 2005;289:C959-70.   DOI
38 Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, et al. Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. Kidney Int 2000;58:1492-9.   DOI   ScienceOn