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http://dx.doi.org/10.15269/JKSOEH.2015.25.3.322

The oral dose toxicity test and skin irritation test of eco-friendly plasticizer using crude glycerol derived  

Kang, Soo-Jung (Department of Polymer Science and Engineering, Sungkyunkwan University)
Kim, Heeyoung (Department of Polymer Science and Engineering, Sungkyunkwan University)
Park, Sangwon (Department of Polymer Science and Engineering, Sungkyunkwan University)
Sim, Eunyoung (Department of Polymer Science and Engineering, Sungkyunkwan University)
Kim, Jinhwan (Department of Polymer Science and Engineering, Sungkyunkwan University)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.25, no.3, 2015 , pp. 322-327 More about this Journal
Abstract
Objectives: The major objective of this study is the oral dose toxicity test and skin irritation test of eco-friendly plasticizer using crude glycerol derived from the biodiesel process. Methods: Glyceroldiacetate laurate(GDL) was synthesized from glycerol monolaurat(GML) and acetic acid. The synthesis of the GDL plasticizer was measured with nuclear magnetic resonance spectroscop(NMR) and FT-IR(Fourier Transform Infrared Spectrometer). To provide information on the safety of GDL, we carried out an oral dose toxicity test for GDL in Sprague-Dawley rats. Also, we carried out a skin irritation test for GDL in New Zealand White rabbits. Results: The oral dose toxicity test in Sprague-Dawley rats showed that GDL is a non-toxic material. The result of the skin irritation test on New Zealand White rabbits showed that GDL is non-irritating. Conclusions: From the results of oral dose toxicity test and skin irritation test, we concluded that the developed plasticizer showed excellent eco-friendly property. Based on our results, we confirmed the development of an eco-friendly non-phthalate plasticizer. Applicability for PVC toys and food and drug packaging materials was found.
Keywords
polyvinylchloride(PVC); eco-friendly; plasticizer; oral dose toxicity test; skin irritation test;
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Times Cited By KSCI : 4  (Citation Analysis)
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