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http://dx.doi.org/10.15269/JKSOEH.2014.24.3.345

Analysis on Urinary N-methylformamide of Korean Workers according to Industrial Classification and Countermeasures for Exposure Control of N,N-dimethylformamide  

Kim, Dohyung (Occupational Safety and Health Research Institutes, Korea Occupational Safety and Health Agency)
Byun, Kiwhan (Occupational Safety and Health Research Institutes, Korea Occupational Safety and Health Agency)
Park, Jae-Oh (Occupational Safety and Health Research Institutes, Korea Occupational Safety and Health Agency)
Lee, Mi-Young (Occupational Safety and Health Research Institutes, Korea Occupational Safety and Health Agency)
Kim, Eun-A (Occupational Safety and Health Research Institutes, Korea Occupational Safety and Health Agency)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.24, no.3, 2014 , pp. 345-352 More about this Journal
Abstract
Objectives: This study is aimed to describe the current situation about urinary biomarker N-methylformamide(NMF) for workers exposed to N,N-dimethylformamide(DMF) according to industrial classification. Materials: Special health examination records of the workers who had undergone urinary biological monitoring in 2013 were collected. The numbers and percentage of workers, whose urinary NMF values were above the limit of detection(LOD) and above the biological exposure index(BEI) were calculated. Health relatedness with DMF as judged by their doctors was also described. All description was classified according to the $9^{th}$ Korean Standard Industrial Classification(KSIC). Results: It appeared that most workers exposed to DMF belong to manufacturing section(80.7%). The geometric mean(GM) values of urinary NMF were 6.25 mg/L, 3.54, and 3.86 for the manufacturing section, professional, scientific and technical activities section, and for the construction section respectively. In detail, it seemed that division of textiles(except apparel) (GM 7.51 mg/L), division of leather, luggage and footwear(11.59 mg/L), and division of rubber and plastic products(6.89 mg/L) were highly exposed to DMF with a high percentage of workers with urinary NMF values above BEI. This was probably due to the effect of skin absorption that the division of leather, luggage and footwear showed the highest urine NMF GM. Conclusions: It seemed that workers in manufacture industries such as textile, leather, luggage, footwear, rubber and plastic products were highly exposed to DMF. So, efforts should be focused on those industries in order to effectively diminish worker's exposure. Further studies to compare DMF air-monitoring with bio-monitoring according to industrial classification should be considered.
Keywords
biological monitoring; DMF; industrial classification; KSIC; NMF;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Hur SJ, Suh CH, Lee CK, Kim JH, Kim DH et al. Evaluation of Work Environment, Health Care Management and Exposure to Chemicals in the Workplaces Using Dimethylformamide (DMF). J Korean Soc Occup Environ Hyg 2010;20(4):225-235   과학기술학회마을
2 American Conference of Governmental Industrial Hygienists (ACGIH). Documentation of the threshold limit values and biological exposure indices (7th edition). Cincinnati, Ohio.;2012.
3 Chung YK, Kim EA, Lee MY, Jang SH, Hwang YI et al. Study on the implementation of the occupational toxic hepatitis surveilance system. Occupational Safety and Health Research Institute (OSHRI, Public Notice No. 122-1350).; 2009. p.17-24
4 He J, Wang P, Zhu J, Wu G, Ji J, Xue Y. Role of urinary biomarkers of N,N-dimethylformamide in the early detection of hepatic injury among occupational exposed workers. Int Arch Occup Environ Health 2010;83:399-406   DOI
5 Hwang YI, Lee MY, Chung YK, Kim EA. Assessment of correlation between markers of ambient monitoring and biological monitoring of dimethylformamide for workers in synthetic leather manufacturing factories in Korea. Analytical Science & Technology 2013;26(5):315-325   과학기술학회마을   DOI
6 Kafferlein HU, Ferstl C, Burkhart-Reichl A, Hennebruder K, Drexler H et al. The use of biomarkers of exposure of N,N-dimethylformamide in health risk assessment and occupational hygiene in the polyacrylic fibre industry. Occup Environ Med 2005;62:330-336   DOI
7 Kim HA, Lee SH, Choi HJ, Hur Y, Lee MY et al. Study on the biological monitoring standards and analytical methods. Occupational Safety and Health Research Institute (OSHRI, Public Notice No. 65-881).; 2010. p.59-80
8 Ministry of Employment and Labor (MoEL). Occupational Safety and Health Acts.; 2014.
9 Occupational Safety and Health Research Institute (OSHRI). Practice Guidelines for Worker's Health Examination Vol 3. (Public Notice No. 2014-OSHRI -392). ;2014. p.27-28
10 Osunsanya T, Adejoro B, King B. Biological monitoring of workers exposed to dimethylformamide in a textile polyurethane unit. Occup Med (Lond) 2001;51:374-379   DOI
11 Tsuda Y, Miyauchi H, Minozoe A, Tanaka S, Arito H et al. Seasonal Difference in Percutaneous Absorption of N,N-Dimethylformamide as Determined Using Two Urinary Metabolites. Journal of Occupational Health 2014, advpub.
12 Wang JD, Lai MY, Chen JS, Lin JM, Chiang JR et al. Dimethylformamide-induced liver damage among synthetic leather workers. Arch Environ Health 1991;46:161-166   DOI   ScienceOn
13 Statistics Korea (KOSTAT). 9th Korean Standard Industrial classification. 2008.[cited 2014 Aug]; Available from URL: http://kostat.go.kr
14 Yoon CS, Ha KC, Lee SM, Byun HJ, Ryu KN et al. Study on the management and prevention of rapid poisoning of DMF handling workers. Occupational Safety and Health Research Institute (OSHRI, Public Notice No. 98-1023).; 2007. p.93-106