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http://dx.doi.org/10.15269/JKSOEH.2014.24.2.160

In Vitro Mammalian Chromosomal Aberration Test of Allyl Chloride for Workers' Health  

Rim, Kyung-Taek (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Kim, Soo-Jin (Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.24, no.2, 2014 , pp. 160-168 More about this Journal
Abstract
Objectives: Chemical hazard evaluations are important for workers' health and working environments. Allyl chloride (CAS No. 107-05-1) is used in many industries, leading to concerns about the possibility of threats to the health of workers. Since only insufficient or controversial information is available about potential related hazards, an in vitro mammalian chromosomal aberration (CA) assay was conducted in order to gain additional information concerning any such hazards. Moreover, toxicological information from this study could be applied for workers' rights to know, and to prepare or update the Materials Safety Data Sheet (MSDS) for a number of industries. Methods and Results: The assay was performed using the Chinese hamster lung fibroblast cell (ATCC, CRL-1935), by the direct method (-S9) and by the metabolic activated method (+S9 mix). Using the direct method, the seven dosages in the 48-hour treatment group did not show that the frequency of CA is proportionate to the dosage. The frequency of CA is not proportionate to the dosage addition for a six-hour treatment using the metabolic activated method. Conclusions: From these findings, it was decided that this chemical does not induce chromosomal aberrations under the tested conditions.
Keywords
Allyl chloride; Chromosomal aberration; in vitro; Chinese hamster lung fibroblast;
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