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Gas Chromatographic Analysis of TDI, MDI and HDI Using 2-Chlorobenzyl Alcohol and 2,4-Dichlorobenzyl Alcohol Derivatives  

Yun, Ju-Song (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University)
Park, Jun-Ho (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University)
Lee, Kang-Myoung (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University)
Choi, Hong-Soon (Department of Preventive Medicine, Public Health College of Medicine, Kwandong University)
Cho, Young-Bong (Department of Environmental Engineering, Yonsei University)
Koh, Sang-Baek (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University)
Cha, Bong-Suk (Department of Preventive Medicine and Institute of Occupational Medicine, Wonju College of Medicine, Yonsei University)
Publication Information
Journal of Korean Society of Occupational and Environmental Hygiene / v.16, no.3, 2006 , pp. 222-232 More about this Journal
Abstract
Objectives: The objective of this study was to propose the total isocyanate analytical method which involves derivation of 2,4-toluene diisocyanate(2,4-TDI), 2,6-toluene diisocyanate(2,6-TDI), 4,4'-methylenediphenyl diisocyanate(4,4'-MDI) and 1,6-hexamethylene diisocyanate(1,6-HDI) using 2-chlorobenzyl alcohol(2-CBA) or 2,4-dichlorobenzyl alcohol(2,4-DCBA), and analyzing of hydrolysate of the synthesized urethane with the gas chromatography(GC)/flame ionization detector(FID), GC/pulsed discharge ionization detector-electron capture detector(PD-ECD) and GC/mass selective detector(MSD). Methods: Urethanes were synthesized by reacting 2,4-TDI, 2,6-TDI, 4,4'-MDI and 1,6-HDI to 2-CBA or 2,4-DCBA. Urethanes was verified by TLC, HPLC/UVD and GC/MSD. For field application, the most suitable condition that 2-CBA coated in glass fiber filter removed completely and urethanes were not removed was searched. 2-CBA generated from hydrolysis of urethanes according to hydrolysis conditions. Diisocyanates were collected on field air and analyzed. Results: Urethanes which were white and solid phase synthesized by reacting 2,4-TDI, 2,6-TDI, 4,4'-MDI, 1,6-HDI and 2-CBA or 2,4-DCBA. And urethanes were verified by TLC, HPLC/UVD and GC/MSD. The most suitable conditions to remove 2-CBA coated in glass fiber filter were $87^{\circ}C$ and 20 mmHg and urethanes were not removed under same condition. Hydrolysis yields of urethanes were 99 % to 111 %. 2-CBA, the hydrolysate of urethanes was analyzed by GC/FID, GC/PD-ECD and GC/MSD. Conclusions: Simultaneous analysis of 2,4-TDI, 2,6-TDI, 4,4'-MDI and 1,6-HDI deriving with 2-CBA and 2,4-DCBA, along with a total isocyanate analysis, was feasible with GC/FID, GC/PD-ECD and GC/MSD. This result will be a guide of further study on total isocyanate analysis.
Keywords
total isocyanate; TDI; MDI; HDI; urethane; gas chromatography;
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