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The Brain Pathology on Recovery of Brain MRI after Manganese Administration in Rats  

Jung, Ji-Hyeon (Department of Occupational & Environmental Medicine, College of Medicine, Dong-A University)
Kim, Jung-Il (Department of Occupational & Environmental Medicine, College of Medicine, Dong-A University)
Kim, Se-Young (Department of Occupational & Environmental Medicine, College of Medicine, Dong-A University)
Jung, Min-Ho (Department of Microbiology, College of Medicine, Dong-A University)
Choi, Soon-Sub (Department of Radiology, College of Medicine, Dong-A University)
Kim, Soo-Jin (Department of Pathology, College of Medicine, Dong-A University)
Park, Young-Jin (Department of Family Medicine, College of Medicine, Dong-A University)
Jung, Kap-Yeol (Department of Occupational & Environmental Medicine, College of Medicine, Dong-A University)
Publication Information
Annals of Occupational and Environmental Medicine / v.22, no.4, 2010 , pp. 371-377 More about this Journal
Abstract
Objectives: This study was carried out to investigate the effect on manganese on the brain of Sprague-Dawley rats, with particular focus on changes to anatomical pathology when brain MRI was recovered after manganese administration. Methods: There were 15 rats divided into 3 groups of 5 based on dose of manganese: control group, low dose group (10 mg/kg), and high dose group (40 mg/kg). Each dosing group received an injection of normal saline and manganese via the tail vein once a week for 4 weeks. And then, the rats were observed for 12 weeks after stopping manganese administration. Next, each rat underwent a brain MRI and then each was sacrificed. After the rats were killed, the concentrations of blood manganese were measured, and pathologic examinations of the brain were performed. Results: The signal intensity of basal ganglia on T1-weighted imaging of brain MRI did not differ between dosing groups. However, the ratio of neuron/glial cell in the basal ganglia was decreased in the low- and high-dose groups compared to the control group. Conclusions: This study showed that the damage of neuron in basal ganglia might be permanent after signal intensity of basal ganglia on T1-weighted imaging of brain MRI was recovered.
Keywords
Manganese; Brain; MRI; Pathology;
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