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http://dx.doi.org/10.7475/kjan.2015.27.3.358

Relationship between Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Patients with Hematologic Malignancies  

Song, Chi Eun (Department of Hematology, Chonnam National University Hwasun Hospital)
Kim, Hye Young (College of Nursing, Chonbuk National University)
Lee, Eun Sook (Department of Nursing, Gyeongnam National University of Science and Technology)
Publication Information
Korean Journal of Adult Nursing / v.27, no.3, 2015 , pp. 358-366 More about this Journal
Abstract
Purpose: This study was aimed to identify the incidence and severity of chemotherapy-induced peripheral neuropathy (CIPN) among patients with hematologic malignancies and to examine the relationship between the quality of life (QOL) and CIPN. Methods: A total of 66 patients with CIPN-related symptoms participated in this study. Data were collected through self-reported questionnaires consisted of the European Organization for Research and Treatment of Cancer QLQ-C30 version 3.0 and the 16-item QLQ-CIPN20. Data were analyzed with SPSS/WIN20 for descriptive statistics using the Mann-Whitney and Kruskal-Wallis tests, and Spearman's rho. Results: The mean lower and upper extremity scale scores were 31.95 and 23.16 respectively for the 16-item QLQ-CIPN20. The mean QLQ-C30 subcategory scores were 46.84 for global health status, 58.72 for functional scales, and 34.85 for symptom scales. The CIPN-related lower extremity scale symptoms correlated negatively with the QOL subscales. There was no correlation between CIPN-related upper extremity symptoms and health-related QOL. Conclusion: Patients with hematologic malignancies treated with neurotoxic chemotherapeutic agents had CIPN-related symptoms in the lower extremities mainly, and their QOL functional subscale scores were relatively lower than those of other cancer patients. Interventions need to be developed for patients with hematologic malignancies to alleviate CIPN and enhance their QOL.
Keywords
Quality of life; Chemotherapy; Peripheral neuropathies; Hematologic malignancy;
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1 Smith EM, Pang H, Cirrincione C, Fleishman S, Paskett ED, Ahles T, et al. Effect of duloxetine on pain, function, and quality of life among patients with chemotherapy-induced painful peripheral neuropathy: a randomized clinical trial. Journal of the American Medical Association. 2013;309(13):1359-67. http://dx.doi.org/10.1001/jama.2013.2813   DOI
2 Yoon J, Jeon JH, Lee YW, Cho CK, Kwon KR, Shin JE, et al. Sweet bee venom pharmacopuncture for chemotherapyinduced peripheral neuropathy. Journal of Acupuncture & Meridian Studies. 2012;5(4):156-65. http://dx.doi.org/10.1016/j.jams.2012.05.003   DOI
3 Cavaletti G, Cornblath DR, Merkies IS, Postma TJ, Rossi E, Frigeni B, et al. The chemotherapy-induced peripheral neuropathy outcome measures standardization study: from consensus to the first validity and reliability findings. Annals of Oncology. 2013;24(2):454-62. http://dx.doi.org/10.1093/annonc/mds329   DOI
4 Kim HY, Kang JH, Song CE, Youn HJ. Chemotherapy-induced peripheral neuropathy and quality of life in breast cancer patients. Asian Oncology Nursing. 201313(4):222-30. http://dx.doi.org/10.5388/aon.2013.13.4.222   DOI
5 Kim HY, Kang JH, Youn HJ, So HS, Song CE, Chae SY, et al. Reliability and validity of the Korean version of the European Organization for Research and Treatment of Cancer Quality of Life questionnaire to assess chemotherapy-induced peripheral neuropathy. Journal of Korean Academy of Nursing. 2014;44(6):735-42. http://dx.doi.org/10.4040/jkan.2014.44.6.735   DOI
6 Faul F, Erdfelder E, Buchner A, Lang AG. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behavior Research Methods. 2009;41(4):1149-60.   DOI
7 Lavoie Smith EM, Barton DL, Qin R, Steen PD, Aaronson NK, Loprinzi CL. Assessing patient-reported peripheral neuropathy: the reliability and validity of the European Organization for Research and Treatment of Cancer QLQ-CIPN20 Questionnaire. Quality of Life Research. 2013;22(10):2787-99. http://dx.doi.org/10.1007/s11136-013-0379-8   DOI
8 Fayers PM, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A, et al. The EORTC QLQ-C30 Scoring Manual. 3rd ed. Brussels: European Organization for Research and Treatment of Cancer 2001.
9 Yun YH, Park YS, Lee ES, Bang SM, Heo DS, Park SY, et al. Validation of the Korean version of the EORTC QLQ-C30. Quality of Life Research. 2004;13(4)863-8.   DOI
10 Wolf SL, Barton DL, Qin R, Wos EJ, Sloan JA, Liu H, et al. The relationship between numbness, tingling, and shooting/burning pain in patients with chemotherapyinduced peripheral neuropathy (CIPN) as measured by the EORTC QLQ-CIPN instrument, N06CA. Supportive Care in Cancer. 2012;20(3):625-32. http://dx.doi.org/10.1007/s00520-011-1141-9   DOI
11 Wolf S, Barton D, Kottschade L, Grothey A, Loprinzi C. Chemotherapy-induced peripheral neuropathy: prevention and treatmentstrategies. European Journal of Cancer. 2008;44:1507-15. http://dx.doi.org/10.1016/j.ejca.2008.04.018   DOI
12 Kwak MK, Kim EJ, Lee ER, Kwon IG, Hwang MS. Characteristics and quality of life in patients with chemotherapyinduced peripheral neuropathy. Journal of Korean Oncology Nursing. 2010;10(2):231-9. http://dx.doi.org/10.5388/jkon.2010.10.2.231   DOI
13 Ocean AJ, Vahdat LT. Chemotherapy-induced peripheral neuropathy: pathogenesis and emerging therapies. Supportive Care in Cancer. 2004;12(9):619-25.   DOI
14 Wickham R. Chemotherapy-induced peripheral neuropathy: a review and implications for oncology nursing practice. Clinical Journal of Oncology Nursing. 2007;11(3):361-76.   DOI
15 Postma TJ, Aaronson NK, Heimans JJ, Muller MJ, Hildebrand JG, Delattre JY, et al. The development of an EORTC quality of life questionnaire to assess chemotherapy-induced peripheral neuropathy: the QLQ-CIPN20. European Journal of Cancer. 2005;41(8):1135-39.   DOI
16 Tofthagen C. Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing. 2010;14(3):E22-8. http://dx.doi.org/10.1188/10.CJON.E22-E28   DOI   ScienceOn
17 Richardson PG, Briemberg H, Jagannath S, Wen PY, Barlogie B, Berenson J, et al. Frequency, characteristics, and reversibility of peripheral neuropathy during treatment of advanced multiple myeloma with bortezomib. Journal of Clinical Oncology. 2006;24(19):3113-20.   DOI   ScienceOn
18 Kautio AL, Haanpaa M, Kautiainen H, Kalso E, Saarto T. Burden of chemotherapy-induced neuropathy-a cross-sectional study. Supportive Care in Cancer. 2011;19(12):1991-6. http://dx.doi.org/10.1007/s00520-010-1043-2   DOI   ScienceOn
19 Delforge M, Blade J, Dimopoulos M, Facon T, Kropff M, Ludwig H, et al. Treatment-related peripheral neuropathy in multiple myeloma: the challenge continues. The Lancet. 2010;11(11):1086-95. http://dx.doi.org/10.1016/S1470-2045(10)70068-1   DOI
20 Chaudhry V, Cornblath DR, Polydefkis M, Ferguson A, Borrello I. Characteristics of bortezomib- and thalidomideinduced peripheral neuropathy. Journal of the Peripheral Nervous System. 2008;13(4):275-82.   DOI
21 Badros A, Goloubeva O, Dalal JS, Can I, Thompson J, Rapoport AP, et al. Neurotoxicity of bortezomib therapy in multiple myeloma: a single-center experience and review of the literature. Cancer. 2007;110(5):1042-9.   DOI
22 Berkowitz A, Walker S. Bortezomib-induced peripheral neuropathy in patients with multiple myeloma. Clinical Journal of Oncology Nursing. 2012;16(1):86-9. http://dx.doi.org/10.1188/12.CJON.86-89   DOI
23 Kim JH, Choi KS, Kim TW, Hong YS. Quality of life in colorectal cancer patients with chemotherapy-induced peripheral neuropathy. Journal of Korean Oncology Nursing. 2011;11(3):254-62. http://dx.doi.org/10.5388/jkon.2011.11.3.254   DOI
24 Barton DL, Wos EJ, Qin R, Mattar BI, Green NB, Lanier KS, et al. A double-blind, placebo-controlled trial of a topical treatment for chemotherapy-induced peripheral neuropathy: NCCTG trial N06CA. Supportive Care in Cancer. 2011;19(6):833-41. http://dx.doi.org/10.1007/s00520-010-0911-0   DOI
25 Kiser DW, Greer TB,Wilmoth MC, Dmochowski J, Naumann RW. Peripheral neuropathy in patients with gynecologic cancer receiving chemotherapy: patient reports and provider assessment. Oncology Nursing Forum. 2010;37(6):758-64. http://dx.doi.org/10.1188/10.ONF.758-764   DOI   ScienceOn
26 Tofthagen C, McAllister RD, McMillan SC. Peripheral neuropathy in patients with colorectal cancer receiving oxaliplatin. Clinical Journal of Oncology Nursing. 2011;15(2):182-8. http://dx.doi.org/10.1188/11.CJON.182-188   DOI   ScienceOn
27 Visovsky C, Collins M, Abbott L, Aschenbrenner J, Hart C. Putting evidence into practice: evidence-based interventions for chemotherapy-induced peripheral neuropathy. Clinical Journal of Oncology Nursing. 2007;11(6):901-13.   DOI
28 Clark PG, Cortese-Jimenez G, Cohen E. Effects of reiki, yoga, or meditation on the physical and psychological symptoms of chemotherapy-induced peripheral neuropathy: arandomized pilot study. Journal of Evidence-Based Complementary & Alternative Medicine. 2012;17(3):161-71. http://dx.doi.org/10.1177/2156587212450175   DOI
29 Donald GK, Tobin I, Stringer J. Evaluation of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Acupuncture in Medicine. 2011;29(3):230-3. http://dx.doi.org/10.1136/acupmed.2011.010025   DOI