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http://dx.doi.org/10.12772/TSE.2019.56.065

Effect of the Ceramide-Contained 3-D Fiber Matrix on Atopic Dermatitis in the NC/Nga Mice  

Yang, Gwang Wung (TN(Think Nature) Solution Co., Ltd.)
Rho, Yong Hwan (TN(Think Nature) Solution Co., Ltd.)
Kim, Eui Hwa (Department of Textile Materials Engineering, Shinhan University)
Lee, Seung Hoon (Amogreentech Co., Ltd.)
Kim, Chan (Amogreentech Co., Ltd.)
Publication Information
Textile Science and Engineering / v.56, no.1, 2019 , pp. 65-77 More about this Journal
Abstract
In this study, we worked on a fiber structure containing ceramide and evaluated its impacts on the wet and dry-type atopic caused by the atopic dermatitis (AD) ointment and TNCB in the NC/Nga Mice. We also measured and evaluated the ability to control the enzyme activity in the DNA and RNA levels using the enzyme-linked immunosorbent assay analysis, sensory evaluation, TWEL (transepidermal water loss) and moisture content measurements. We conducted a statistical analysis to assess the improvements in AD and the mitigation between the control groups using a histopathological analysis and the Western blotting evaluation. The amount of TWEL in the TNCB group, which is a wet-type atopicinduced group, was significantly higher than that in the dry-type AD-induced group. A serological analysis revealed a significant reduction of the Immunoglobulin E level in all the wearing groups (M-1, M2, C-1, C-2) compared to the negative control on the 35th day of the experiment. It was confirmed that the ceramide-contained 3-D fiber structure recovers and improves the skin barrier function among the Nc/Nga mice. The NC/Nga mice in-vivo results of the ceramide-containing 3-D fiber matrix are applicable in the design of customized skin care garments effective in relieving and improving the dry and wet-type AD.
Keywords
atopic dermatitis; ceramide; 3-D fiber matrix; NC/Nga mice; TWEL;
Citations & Related Records
Times Cited By KSCI : 2  (Citation Analysis)
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