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http://dx.doi.org/10.5933/JKAPD.2020.47.3.266

Effect of Silver Diamine Fluoride and Sodium Fluoride Varnish on Remineralization in Artificially Induced Enamel Caries: An in vitro Study  

Kim, Soyoung (Department of Pediatric Dentistry, School of Dentistry, Chosun University)
Lee, Sangho (Department of Pediatric Dentistry, School of Dentistry, Chosun University)
Lee, Nanyoung (Department of Pediatric Dentistry, School of Dentistry, Chosun University)
Jih, Myeongkwan (Department of Pediatric Dentistry, School of Dentistry, Chosun University)
Publication Information
Journal of the korean academy of Pediatric Dentistry / v.47, no.3, 2020 , pp. 266-276 More about this Journal
Abstract
The purpose of this study was to compare the remineralization effect of 38% silver diamine fluoride (SDF) and 5% sodium fluoride (NaF) varnish on artificially induced enamel caries. The present study standardized the physiochemical characteristics of the tooth structure using bovine teeth, realized the wash-off action of agents using a saliva, reproduced an environment similar to mouth through pH-cycling, and comparatively assessed the remineralization effect of 38% SDF and 5% NaF varnish in a non-destructive method using micro-CT. And the remineralized enamel surface structure was analyzed by scanning electron microscopy (SEM) and energy dispersive X-Ray spectroscopy (EDS). In both SDF and NaF varnish, mineral density (△Hounsfield unit value) and the volume of enamel restored to normal mineral density through remineralization gradually increased with time. And the SDF showed a much higher level of increase in mineral density at all depths and remineralized volume than NaF varnish. According to SEM analysis, the surface roughness decreased in the order of artificial saliva, NaF varnish and SDF. In addition, EDS analysis showed that silver ion was precipitated on the enamel surface in SDF group. In conclusion, SDF had a greater remineralization effect than NaF varnish on demineralized enamel.
Keywords
Silver diamine fluoride (SDF); NaF varnish; Remineralization; Mineral density; Micro-CT;
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1 Cochrane NJ, Cai F, Huq NL, et al. : New approaches to enhanced remineralization of tooth enamel. J Dent Res, 89:1187-1197, 2010.   DOI
2 Twetman S, Stecksen-Blicks C : Urinary fluoride excretion after a single application of fluoride varnish in preschool children. Oral Health Prev Dent, 16:351-354, 2018.
3 Gotjamanos T : Pulp response in primary teeth with deep residual caries treated with silver fluoride and glass ionomer cement ('atraumatic' technique). Aust Dent J, 41:328-334, 1996.   DOI
4 Mei ML, Lo EC, Chu CH : Clinical use of silver diamine fluoride in dental treatment. Compend Contin Educ Dent, 37:93-98, 2016.
5 Burgess JO, Vaghela PM : Silver diamine fluoride: A successful anticarious solution with limits. Adv Dent Res, 29:131-134, 2018.   DOI
6 Clemens J, Gold J, Chaffin J : Effect and acceptance of silver diamine fluoride treatment on dental caries in primary teeth. J Public Health Dent, 78:63-68, 2018.   DOI
7 Crystal YO, Marghalani AA, Ureles SD, et al. : Use of silver diamine fluoride for dental caries management in children and adolescents, including those with special health care needs. Pediatr Dent, 39:135-145, 2017.
8 Wright JT, White A : Silver diamine fluoride: changing the caries management paradigm and potential societal impact. NC Med J, 78:394-397, 2017.
9 Zhao IS, Gao SS, Hiraishi N, et al. : Mechanisms of silver diamine fluoride on arresting caries: a literature review. Int Dent J, 68:67-76, 2018.   DOI
10 Mei ML, Li QL, Chu CH, et al. : Antibacterial effects of silver diamine fluoride on multi-species cariogenic biofilm on caries. Ann Clin Microbiol Antimicrob, 26:12-14, 2013.
11 Shah S, Bhaskar V, Venkataraghavan K, et al. : Efficacy of silver diamine fluoride as an antibacterial as well as antiplaque agent compared to fluoride varnish and acidulated phosphate fluoride gel: an in vivo study. Indian J Dent Res, 24:575-581, 2013.   DOI
12 Delbem AC, Bergamaschi M, Sassaki KT, et al. : Effect of fluoridated varnish and silver diamine fluoride solution on enamel demineralization: pH-cycling study. J Appl Oral Sci, 14:88-92, 2006.   DOI
13 Mohammadi N, Farahmand Far MH : Effect of fluoridated varnish and silver diamine fluoride on enamel demineralization resistance in primary dentition. J Indian Soc Pedod Prev Dent, 36:257-261, 2018.   DOI
14 Mei ML, Li QL, Chu CH, et al. : The inhibitory effects of silver diamine fluoride at different concentrations on matrix metalloproteinases. Dent Mater, 28:903-908, 2012.   DOI
15 Trieu A, Mohamed A, Lynch E : Silver diamine fluoride versus sodium fluoride for arresting dentin caries in children: a systematic review and meta-analysis. Sci Rep, 9:2115, 2019.   DOI
16 Altenburger MJ, Schirrmeister JF, Lussi A, et al. : In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride. Eur J Oral Sci, 117:58-63, 2009.   DOI
17 ten Cate JM, Duijsters PP : Alternating demineralization and remineralization of artificial enamel lesions. Caries Res, 16:201-210, 1982.   DOI
18 Rosenblatt A, Stamford TC, Niederman R : Silver diamine fluoride: a caries ''silver-fluoride bullet''. J Dent Res, 88:116-125, 2009.   DOI
19 Yu OY, Mei ML, Zhao IS, et al. : Remineralisation of enamel with silver diamine fluoride and sodium fluoride. Dent Mater, 34:e344-e352, 2018.   DOI
20 Naumova EA, Niemann N, Aretz L, et al. : Effects of different amine fluoride concentrations on enamel remineralization. J Dent, 40:750-755, 2012.   DOI
21 Shah SG, Bhaskar V, Chawla S, et al. : Efficacy of silver diamine fluoride as a topical fluoride agent compared to fluoride varnish and acidulated phosphate fluoride gel: An in vivo study. J Pediatr Dent, 2:5-12, 2014.   DOI
22 Cho SG, Kim JB, Kim JS : Remineralization effects on the demineralized enamel of primary teeth by fluoride varnish. J Korean Acad Pediatr Dent, 43:44-50, 2016.
23 Fernandez CE, Tenuta LM, Zarate P, Cury JA : Insoluble NaF in $Duraphat^{(R)}$ may prolong fluoride reactivity of varnish retained on dental surfaces. Braz Dent J, 25:160-164, 2014.   DOI
24 Neboda C, Anthonappa RP, King NM : Tooth mineral density of different types of hypomineralised molars: a micro-CT analysis. Eur Arch Paediatr Dent, 18:377-383, 2017.   DOI