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http://dx.doi.org/10.5933/JKAPD.2022.49.3.300

Effects of Ginsenoside Rb1 Loaded Films on Oral Wound Healing  

Jeong Hyun, Lee (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Seung Hwan, Park (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Asiri Naif, Mohammed (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Myoung-Han, Lee (Jinwoo Bio Co., Ltd.)
Dong-Keon, Kweon (Jinwoo Bio Co., Ltd.)
Yongkwon, Chae (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Koeun, Lee (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Misun, Kim (Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University)
Hyoseol, Lee (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Sungchul, Choi (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Ok Hyung, Nam (Department of Pediatric Dentistry, Kyung Hee University Dental Hospital)
Publication Information
Journal of the korean academy of Pediatric Dentistry / v.49, no.3, 2022 , pp. 300-309 More about this Journal
Abstract
This study aimed to evaluate the effects of two ginsenoside Rb1 (G-Rb1) loaded films on oral wound healing. Two types of G-Rb1 films, G-Rb1 loaded carboxymethyl cellulose (GCMC) film and G-Rb1 loaded hyaluronic acid (GHA) film, were developed. A total of 36 Sprague-Dawley rats were divided into 3 groups: control, GCMC, and GHA. After wound formation on midpalate, the control group was left without treatment, whereas the experimental groups had films attached. The specimen was analyzed clinically and histologically after 7 and 21 days. For clinical analysis, the area of incompletely re-epithelialized wound was measured. For histological analysis, the distance between the margins of the wound (soft tissue gap) was measured and the percentage of the collagen-stained area on the specimen was calculated. In clinical and soft tissue gap analysis, the GCMC group presented improved healing compared to the GHA group and the control at day 7 (p < 0.05). And, both GCMC (9.74 ± 10.12%) and GHA groups (19.50 ± 14.47%) presented greater collagen-positive pixels compared to control (0.89 ± 1.60%) at day 7 (p < 0.05). However, there were no differences in these parameters among the groups on day 21. Therefore, G-Rb1 loaded films improved oral wound healing.
Keywords
Ginsenoside Rb1; Carboxymethyl cellulose; Hyaluronic acid; Wound healing; Re-epithelialization;
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Times Cited By KSCI : 4  (Citation Analysis)
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