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http://dx.doi.org/10.5010/JPB.2017.44.1.076

In vitro anti-inflammatory activity of extracts from Potentilla supina in murine macrophage RAW 264.7 cells  

Nam, Jung-Hwan (Highland Agriculture Research Institute, National Institute of Crop Science, RDA)
Kim, Hyun-Sam (Agricultural support, Yanggu County Office)
Kim, Byoumg-Jin (Agricultural Technology Center, Yanggu County Office)
Yu, Hong-Seob (Highland Agriculture Research Institute, National Institute of Crop Science, RDA)
Chang, Dong-Chil (Highland Agriculture Research Institute, National Institute of Crop Science, RDA)
Jin, Yong-Ik (Highland Agriculture Research Institute, National Institute of Crop Science, RDA)
Yoo, Dong-Lim (Highland Agriculture Research Institute, National Institute of Crop Science, RDA)
Choi, Jong-Keun (Highland Agriculture Research Institute, National Institute of Crop Science, RDA)
Park, Hee-Jhun (Dept. of Pharmaceutical Engineering, College of Health Sciences, Sang-ji University)
Lee, Seung-Bin (Dept. of pharmaceutical, College of Pharmacy, Kyung-Hee University)
Lee, Kyung-Tea (Dept. of pharmaceutical, College of Pharmacy, Kyung-Hee University)
Park, Soo-Jin (Dept. of Food and Nutrition, Semyung University)
Publication Information
Journal of Plant Biotechnology / v.44, no.1, 2017 , pp. 76-81 More about this Journal
Abstract
Potentilla supina (Rosaceae) has traditionally been used to treat disorders of hemostasis, dysentery, malaria, bloody discharge and arthritis, and it has antinociceptive and anti-inflammatory properties. However, validity of the anti-inflammatory activity has not been scientifically investigated so far. Therefore, the aim of this study was to investigate the anti-inflammatory potential of P. supina using the ethanolic extract of P. supina and its sub-fractions. To evaluate the anti-inflammatory effects of P. supina, we examined the inflammatory mediators such as nitric oxide (NO), inducible nitric oxide synthase (iNOS) and prostaglandin $E_2$ ($PGE_2$) in RAW 264.7 cells. Our results indicated that ethyl acetate fraction significantly inhibited LPS-induced NO, iNOS and $PGE_2$ production in RAW 264.7 cells. This result showed that ethyl acetate fraction of P. supina is expected to be a good candidate for development into a source of anti-inflammatory agents.
Keywords
Potentilla supina; Anti-inflammatory effect; Nitric oxide (NO); Inducible nitric oxide synthase (iNOS); Prostaglandin $E_2$ ($PGE_2$); RAW 264.7 cells;
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Times Cited By KSCI : 9  (Citation Analysis)
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