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http://dx.doi.org/10.5010/JPB.2013.40.1.001

Development of transgenic potato with high content of sulphur-containing essential amino acids  

Goo, Young-Min (Sancheong Oriental Medicinal Herb Institute)
Kim, Tae-Won (Department of Agronomy & Medicinal Plant Resources, College of Life Science and Natural Resources, Gyungnam National University of Science & Technology)
Lee, Min-Kyung (Department of Agronomy & Medicinal Plant Resources, College of Life Science and Natural Resources, Gyungnam National University of Science & Technology)
Lee, Shin-Woo (Department of Agronomy & Medicinal Plant Resources, College of Life Science and Natural Resources, Gyungnam National University of Science & Technology)
Publication Information
Journal of Plant Biotechnology / v.40, no.1, 2013 , pp. 1-8 More about this Journal
Abstract
Potato is the 4th important crop along with rice, wheat and maize. It contains high quality of starch with relatively high content of vitamin C and protein. However, there is a nutritionally limiting factor due to a low level of sulphur-containing essential amino acid including methionine and cysteine. Recently, recombinant DNA technology and metabolic engineering with genes involved in the bio-synthetic pathway have been applied to enhance the level of these essential amino acids. In this report, it has been discussed about the current status and bottleneck on the development of transgenic potato containing high level of sulphur-containing essential amino acids.
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1 Snyder JC, Desborough SL (1980) Total protein and protein fractions in tubers of Group Anigena and Phureja-Tuberosum hybrids. Qual Plant Foods Hum Nutr 30:123-134   DOI
2 Stiller I, Dancs G, Hesse H, Hoefgen R, Bánfalvi Z (2007) Improving the nutritive value of tubers: Elevation of cysteine and glutathione contents in the potato cultivar White Lady by marker-free transformation. J Biotechnol 128:335-343   DOI   ScienceOn
3 Sun SSM, Altenbach SB, Leung FW (1987) Properties, biosynthesis and processing of a sulfur-rich protein in Brazil nut (Bertholletia excelsa H.B.K.). Eur J Biochem 159:597-604
4 Thompson GA, Datko AH, Mudd SH (1982) Methionine biosynthesis in Lemna: studies on the regulation of cystathionine gamma-synthase, O-phosphohomoserine sulfhydrylase, and O-acetyl sulfhydrylase. Plant Physiol 69:1077-1083   DOI   ScienceOn
5 Tu HM, Godfrey LW, Sun SSM (1998) Expression of the Brazil nut methionine-rich protein and mutants with increased methionine in transgenic potato. Plant Mol Biol 37:829-838   DOI   ScienceOn
6 Zeh M, Casazza AP, Kreft O, Roessner U, Bieberich K, Willmitzer L, Hoefgen R, Hesse H (2001) Antisense inhibition of threonine synthase leads to high methionine content in transgenic potato plants. Plant Physiol 127:792-802   DOI
7 Kirihara JA, Hunsperger JP, Mahoney WC, Messing JW (1988) Differential expression of a gene for a methionine-rich storage protein in maize Mol. Gen. Genet. 211:477-484   DOI
8 Kreft O, Hoefgen R, Hesse H (2003) Functional analysis of cystathionine -synthase in genetically engineered potato plants. Plant Physiol 131:1843-1854   DOI   ScienceOn
9 Liedl BE, Kosier T, Desborough SL (1987) HPLC isolation and nutritional value of a major tuber protein. Amer. Potato J 64:545-557.   DOI
10 Maimann S, Wagner C, Kreft O, Zeh M, Willmitzer L, Hofgen R, Hesse H (2000) Transgenic potato plants reveal the indispensable role of cystathionine ${\beta}$-lyase in plant growth and development. Plant J. 23:747-758   DOI   ScienceOn
11 Maimann S, Hoefgen R, Hesse H (2001) Enhanced cystathionine ${\beta}$-lyase activity in transgenic potato plants does not force metabolite flow towards methionine. Planta 214:163-170   DOI
12 Nikiforova V, Kempa S, Zeh M, Maimann S, Kreft O, Casazza AP, Riedel K, Tauberger E, Hoefgen R, Hesse H (2002) Engineering of cysteine and methionine biosynthesis in potato. Amino Acids 22:259-278   DOI
13 Pavia E, Lister RM, Park WD (1983) Induction and accumulation of major tuber proteins of potato stems and petioles. Plant Physiol. 71:161-168   DOI   ScienceOn
14 Pedersen K, Agros P, Naravana SVL, Larkins B (1986) Sequence analysis and characterization of a maize gene encoding a high-sulfur zein protein of Mr 15,000. J Biol Chem 261: 6279-6284
15 Pots AM, Grotenhuis ET, Gruppen H, Voragen AGJ, de Kruif KG (1999) Thermal aggregation of patatin studied in situ. J Agric Food Chem 47:4600-4605   DOI   ScienceOn
16 Raina A, Datta A (1992) Molecular cloning of a gene encoding a seed-specific protein with nutritionall balanced amino acid composition from Amaranthus. Proc Natl Acad Sci USA 89:11774-11778   DOI   ScienceOn
17 Ravanel S, Gakiere B, Job D, Douce R (1998) The specific features of methionine biosynthesis and metabolism in plants. Proc Nat Acad Sci USA 95:7805-7812   DOI   ScienceOn
18 Saito K, Kurosawa M, Tatsuguchi K, Tagaki Y, Murakoshi I (1994) Modulation of cysteine biosynthesis in chloroplasts of transgenic tobacco overexpressing cysteine synthase(O-acetylserine (thiol)-lyase, Plant Physiol 106:887-895   DOI   ScienceOn
19 Rinder J, Casazza AP, Hoefgen R, Hesse H (2008) Regulation of aspartate-derived amino acid homeostasis in potato plants (Solanum tuberosum L.) by expression of E. coli homoserine kinase. Amino Acids 34:213-222   DOI
20 Ruffet M-L, Droux M, Douce R (1994) Purification and kinetic properties of serine acetyltransferase free of O-acetylserine (thiol)lyase from spinach chloroplasts. Plant Physiol 104: 597-604   DOI
21 Shaul O, Galili G (1992) Threonine overproduction in transgenic tobacco plants expressing a mutant desensitized aspartate kinase of Escherichia coli. Plant Physiol 100:1157–1163   DOI   ScienceOn
22 Shewry PR (2003) Tuber storage proteins. Ann Bot 91:755-769   DOI   ScienceOn
23 Bryan JK (1980) Synthesis of the aspartate family and branchedchain amino acids. In: Miflin BJ (ed) The biochemistry of plants, vol 5. Academic Press, New York, pp 403-452
24 Casazza AP, Basner A, Höfgen R, Hesse H (2000) Expression of threonine synthase from Solanum tuberosum L. is not metabolically regulated by photosynthesis-related signals or by nitrogenous compounds. Plant Sci 157:43-50   DOI   ScienceOn
25 Chakraborty S, Chakraborty N, Datta A (2000) Increased nutritive value of transgenic potato by expressing a nonallergenic seed albumin gene from Amaranthus hypochondriacus. Proc Natl Acad Sci USA 97:3724-3729   DOI   ScienceOn
26 Chiba Y, Ishikawa M, Kijima F, Tyson RH, Kim J, Yamamoto A, Mambara E, Leustek T, Wallsgrove RM, Naito S (1999) Evidence for autoregulation of cystathionine-synthase mRNA stability in Arabidopsis. Sci 286:1371-1374   DOI   ScienceOn
27 Hacham Y, Avraham T, Amir R (2002) The N-terminal region of Arabidopsis cystathionine-synthase plays an important role in methionine metabolism. Plant Physiol 128:454-462   DOI   ScienceOn
28 Dancs G, Mihaly Kondrak M, Banfalvi Z (2008) The effects of enhanced methionine synthesis on amino acid and anthocyanin content of potato tubers. BMC Plant Biol 8:65-75   DOI   ScienceOn
29 Di R, Kim J, Martin MN, Leustck T, Jhoo J, Ho C-T, E. Tumer N (2003) Enhancement of the primary flavor compound methional in potato by increasing the level of soluble methionine. J Agric Food Chem 51:5695-57025   DOI   ScienceOn
30 Gakiere B, Denis L, Droux M, Job D (2002) Over-expression of cystathionine-synthase in Arabidopsis thaliana leads to increased levels of methionine and S-methylmethionine. Plant Physiol Biochem 40:119-126   DOI   ScienceOn
31 Hacham Y, Schuster G, Amir R (2006) An in vivo internal deletion in the N-terminus region of Arabidopsis cystathionine ${\gamma}$-synthase results in CGS expression that is insensitive to methionine. Plant J 45:955-967   DOI   ScienceOn
32 Harms K, von Ballmoos P, Brunold C, Hofgen R, Hesse H (2000) Expression of a bacterial serine acetyltransferase in transgenic potato plants leads to increased levels of cysteine and glutathione. Plant J 22:335-343   DOI   ScienceOn
33 Heremans B, Jacobs M (1995) Threonine accumulation in a mutant of Arabidopsis thaliana (L.) Heynh. with an altered aspartate kinase. J Plant Physiol 146:249-257   DOI   ScienceOn
34 Inaba K, Fujiwara T, Chino M, Komeda Y, Naito S (1994) Isolation of an Arabidopsis thaliana mutant, mto1, that overaccumulates soluble methionine. Plant Physiol 104:881-887   DOI
35 Jin UH, Jin BR, Lee JW, Cho YS, Kwon OC, Kim YK, Chung CH (2000) Characterization of a methionine-rich storage protein cDNA from perilla (Perilla frutescens) seeds. Aust. J. Plant Physiol 27:701-707
36 Bogdanova N, Hell R (1997) Cysteine synthesis in plants: protein-protein interactions of serine acetyltransferase from Arabidopsis thaliana. Plant J 11: 251-262   DOI   ScienceOn
37 Kapoor A, Desborough SL, Li PH (1975) Potato tuber proteins and their nutritional quality. Potato Res 18:469-478   DOI
38 Kim J, Lee M, Chalam R, Martin MN, Leustek T, Boerjan W (2002) Constitutive overexpression of cystathionine-synthase in Arabidopsis leads to accumulation of soluble methionine and S-methylmethionine. Plant Physiol 128: 95-107   DOI
39 Altenbach SB, Pearson KW, Leung FW, Sun SSM (1987) Cloning and sequence analysis of a cDNA encoding a Brazil nut protein exceptionally rich in methionine. Plant Mol Biol 13:513-522