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http://dx.doi.org/10.5010/JPB.2010.37.3.269

Edible vaccine for aquacultured fish: present and prospect  

Park, Eun-Joon (Gendocs Inc.)
Kim, Mi-Na (Gendocs Inc.)
Park, Ju-Young (Gendocs Inc.)
Cha, Jae-Ho (Gendocs Inc.)
Chung, Hwa-Jee (Gendocs Inc.)
Publication Information
Journal of Plant Biotechnology / v.37, no.3, 2010 , pp. 269-274 More about this Journal
Abstract
As the capture fishing industry has declined, the aquaculture industry has become an important source of seafood. With this tendency all fish farming will be performed by large-scale farms where the fish are cultivated in much high density and as a result the incidence of infectious diseases increases. Therefore, vaccination has become an increasingly important part of aquaculture as a cost effective method of controlling various diseases. The early fish vaccines were the formalin inactivated bacteria or virus cultures, which were administered by either immersion or injection. Recombinant DNA biotechnology allowed us to develop orally administrated DNA and recombinant vaccines. In terms of the manufacturing process and cost, Lemna and Spirodela is the most efficient and reliable plant expression system for the production of edible vaccine.
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