Plant-based production of therapeutic antibodies
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Kim, Young-Kwan
(Department of Biological Science, College of Natural ciences, Wonkwang University)
So, Yang-Kang (Department of Biological Science, College of Natural ciences, Wonkwang University) Park, Da-Young (Department of Biological Science, College of Natural ciences, Wonkwang University) Kim, Hyun-Soon (Plant systems engineering research center, Korea Research Institute of Bioscience and Biotechnology) Jeon, Jae-Heung (Plant systems engineering research center, Korea Research Institute of Bioscience and Biotechnology) Choo, Young-Kug (Department of Biological Science, College of Natural ciences, Wonkwang University) Ko, Ki-Sung (Department of Biological Science, College of Natural ciences, Wonkwang University) |
1 | Melo NS, Nimtz M, Conradt HS, Fevereiro PS, Costa J (1997) Identification of the human Lewis(a) carbohydrate motif in a secretory peroxidase from a plant cell suspension culture (Vaccinium myrtillus L.). FEBS Lett 415:186-191 DOI |
2 | Miele L (1997) Plants as bioreactors for biopharmaceuticals:regulatory considerations. Trends Biotechnol 15:45-50 DOI |
3 | Pen J (1996) Comparison of host systems for the production of recombinant proteins. In Transgenic plants:a production system for industrial and pharmaceutical proteins. John Wiley and Sons Ltd 149-167 |
4 | Priem B, Gitti R, Bush CA, Gross KC (1993) Structure of ten free N-glycans in ripening tomato fruit. Plant Physiol 102:445-458 DOI |
5 | Ruf S, Hermann M, Berger IJ, Carrer H, Bock R (2001) Stable genetic transformation of tomato plastids and expression of a foreign protein in fruit. Nat Biotechnol 19:870-875 DOI |
6 | Shah MM, Fujiyama K, Flynn CR, Joshi L (2003) Sialylated endogenous glycoconjugates in plant cells. Nat Biotechnol 21:1470-1471 DOI |
7 | Jefferis R, Lund J, Pound JD (1998) IgG-Fc-mediated effector functions:molecular definition of interaction sites for effector ligands and the role of glycosylation. Immunol Rev 163:50-76 |
8 | Ko K, Steplewski Z, Glogowska M, Koprowski H (2005) Inhibition of tumor growth by plant-derived mAb. Proc Natl Acad Sci USA 102:7026-7030 DOI |
9 | Ko K, Koprowski H (2005) Plant biopharming of monoclonal antibodies. Virus Res 111:93-100 DOI |
10 | Ko K, Tekoah Y, Rudd PM, Harvey DJ, Dwek RA, Spitsin S, Hanlon CA, Rupprecht C, Dietzschold B, Golovkin M, Koprowski H (2003) Function and glycosylation of plantderived antiviral monoclonal antibody. Proc Natl Acad Sci USA 100:8013-8018 DOI |
11 | Kornfeld R, Kornfeld S (1985) Assembly of asparagine-linked oligosaccharides. Annu Rev Biochem 54:631-664 DOI |
12 | Kermode AR (1996) Mechanisms of intracellular protein transport and targeting in plant cells. Crit Rev Plant Sci 15:285-423 DOI |
13 | Koziel MG, Carozzi NB, Desai N (1996) Optimizing expression of transgenes with an emphasis on post-transcriptional events. Plant Mol Biol 32:393-405 DOI |
14 | Kuby J (1997) Immunology. Third Edition. W. H. Freeman and Company, New York. 664. |
15 | Kusnadi, AR, Evangelista RL, Hood EE, Howard J, Nikolov ZL (1998) Production and purification of two recombinant proteins from transgenic corn. Biotechnol Progress 14:149-155 DOI |
16 | Lerouge P, Cabanes-Macheteau M, Rayon C, Fischette-Laine AC, Gomord V, Faye L (1998) N-glycosylation biosynthesis in plants:recent developments and future trends. Plant Mol Biol 38:31-48 DOI |
17 | Faye L, Johnson KD, Sturm A, Chrispeels MJ (1989) Structure, biosynthesis, and function of asparagine-linked glycans on plant glycoproteins. Physiologia Plantarum 75:309-314 DOI |
18 | Fitchette AC, Gomord V, Chekkafi A, Faye A (1994) Distribution of xylosylation and fucosylation in the plant Golgi apparatus. Plant J 5:673-682 DOI |
19 | Fitchette AC, Cabanes-Macheteau M, Marvin L, Martin B, Satiat-Jeunemaitre B, Gomord V, Crooks K, Lerouge P, Faye L, Hawes C (1999) Biosynthesis and immunolocalization of Lewis a-containing N-glycans in the plant cell. Plant Physiol 121:333-344 DOI |
20 | Fitchette AC, Gomord V, Cabanes M, Michalski JC, Saint Macary M, Foucher B, Cavelier B, Hawes C, Lerouge P, Faye L (1997) N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells. Plant J 12:1411-1417 DOI |
21 | Fraley RT, Rogers SG, Horsch RB, Sanders PR, Flick JS, Adams SP, Bittner ML, Brand LA, Fink CL, Fry JS, Galluppi GR, Goldberg SB, Hoffmann NL, Woo SC (1983) Expression of bacterial genes in plant cells. Proc Natl Acad Sci USA 80:4803-4807 DOI |
22 | Gomord W, Chamberlain P, Jefferis R, Faye L (2005) Biopharmaceutical production in plants:problems, solutions and opportunities. Trends in Biotechno 23:559-565 DOI |
23 | Horsch RB, Fraley RT, Rogers SG, Sanders PR, Lloyd A, Hoffman N (1984) Inheritance of functional foreign genes in plants. Science 223:496-498 DOI |
24 | Jamal A, Ahn MH, Song M, Oh EY, Hong J, Choo YK, Ko K, Han YS, Oh SH, Van Der Linden J, Leusen JH, Ko K (2009) Biological Validation of Plant-Derived Anti-Human Colorectal Cancer Monoclonal Antibody CO17-1A. Hybridoma 28:7-12 DOI ScienceOn |
25 | Brodzik R, Glogowska M, Bandurska K, Okulicz M, Deka D, Ko K, van der Linden J, Leusen JH, Pogrebnyak N, Golovkin M, Steplewski Z, Koprowski H (2006) Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells. Proc Natl Acad Sci USA 103:8804-8809 DOI |
26 | Conrad U, Fiedler U, Artsaenko O, Phillips J (1998) High-level and stable accumulation of single-chain Fv antibodies in plant storage organs. J Plant Physiol 152:708-711 DOI ScienceOn |
27 | Cabanes-Macheteau M, Fitchette-Lainé AC, Loutelier-Bourhis C, Lange C, Vine ND, Ma JK, Lerouge P, Faye L (1999) N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants. Glycobiology 9:365-372 DOI |
28 | Capon C, Piller F, Wieruszeski JM, Leroy Y, Fournet B (1990) Structural analysis of the carbohydrate chain isolated from jacalin lectin. Carbohydr Res 199:121-127 DOI |
29 | Conrad U, Fiedler U (1998) Compartment-specific accumulation of recombinant immunoglobulins in plant cells:an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol Biol 38:101-109 DOI |
30 | D’Andrea G, Bouwstra B, Kamerling JP, Vliegenhart JFG (1988) Primary structure of the xylose-containing N-linked carbohydrate moiety from ascorbic acid oxidase of Cucurbita pepo medullosa. Glycoconj J 5:151-157 DOI |
31 | Daniell H (2002) Molecular strategies for gene containment in transgenic crops. Nat Biotechnol 20:581-586 |
32 | De Wilde C, Van Houdt H, De Buck S, Angenon G, De Jaeger G, Depicker A (2000) Plants as bioreactors for protein production: avoiding the problem of transgene silencing. Plant Mol Biol 43:347-359 |
33 | Doran P (2000) Foreign Protein Production in Plant Tissue Cultures. Current Opinion in Biotechnology 11:199-204 DOI |
34 | Bakker H, Bardor M, Molthoff JW, Gomord V, Elbers I, Stevens LH, Jordi W, Lommen A, Faye L, Lerouge P, Bosch, D (2001) Galactose-extended glycans of antibodies produced by transgenic plants. Proc Natl Acad Sci USA 98:2899-2904 DOI |
35 | Armour, KL, Clark MR, Hadley AG, Williamson LM (1999) Recombinant human IgG molecules lacking Fc-gamma Receptor I binding and monocyte triggering activities. Eur J Immunol 29:2613-2624 DOI |
36 |
Ashford DA, Dwek RA, Welply JK, Amatayakul S, Homans SW, Lis H, Taylor GN, Sharon N, Rademacher, TW (1987) The |
37 | Breedveld FC (2000) Therapeutic monoclonal antibodies. Lancet 355:735-740 DOI |
38 | Balen B, Krsnik-Rasol M, Zamfir AD, Milo J, Vakhrushev SY, Peter-Katalini J (2006) Glycoproteomic survey of Mammillaria gracillis tissues grown in vitro. J Proteome Res 5:1658-1666 DOI |
39 | Strasser R, Altmann F, Mach L, Glossl J, Steinkellner H (2004) Generation of Arabidopsis thaliana plants with complex N-glycans lacking beta1,2-linked xylose and core alpha1, 3-linked fucose. FEBS Lett 561:132-136 DOI |
40 | Shields RL, Namenuk AK, Hong K, Meng YG, Rae J, Briggs J, Xie D, Lai J, Stadlen A, Li B, Fox JA, Presta LG (2001) High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 276:6591-6604 DOI ScienceOn |
41 | Tekoah Y, Ko K, Koprowski H, Harvey DJ, Wormald MR, Dwek RA, Rudd PM (2004) Controlled glycosylation of therapeutic antibodies in plants. Arch Biochem Biophys 426:266-278 DOI |
42 | Ma JKC, Vine ND (1999) Plant expression systems for the production of vaccines. Curr Top Microbiol Immunol 236:275-292 DOI |
43 | Ma JK, Chikwamba R, Sparrow P, Fischer R, Mahoney R, Twyman RM (2005) Plant-derived pharmaceuticals-the road forward. Trends Plant Sci 10:580-585 DOI |
44 | Ma JK, Drake PM, Christou P (2003) The production of recombinant pharmaceutical proteins in plants. Nat Rev Genet 4:794-805 DOI |
45 | Ma JK, Hiatt A, Hein M., Vine ND, Wang F, Stabila P, van Dolleweerd C, Mostov K, Lehner T (1995) Generation and assembly of secretory antibodies in plants. Science 268:716-719 DOI |
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