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Animal Models of Demyelination and 1H-Magnetic Resonance Spectroscopy  

Cho, Han Byul (The Brain Institute, University of Utah)
Lee, Suji (Ewha Brain Institute, Ewha Womans University)
Park, Shinwon (Ewha Brain Institute, Ewha Womans University)
Kang, Ilhyang (Ewha Brain Institute, Ewha Womans University)
Ma, Jiyoung (Ewha Brain Institute, Ewha Womans University)
Jeong, Hyeonseok S. (Department of Radiology, The Catholic University of Korea, Incheon St. Mary's Hospital)
Kim, Jieun E. (Ewha Brain Institute, Ewha Womans University)
Yoon, Sujung (Ewha Brain Institute, Ewha Womans University)
Lyoo, In Kyoon (Ewha Brain Institute, Ewha Womans University)
Lim, Soo Mee (Ewha Brain Institute, Ewha Womans University)
Kim, Jungyoon (Ewha Brain Institute, Ewha Womans University)
Publication Information
Korean Journal of Biological Psychiatry / v.24, no.1, 2017 , pp. 1-9 More about this Journal
Abstract
The proton magnetic resonance spectroscopy ($^1H-MRS$) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
Keywords
Proton magnetic resonance spectroscopy; Demyelination; Animal models;
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