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Association Study of ANK3 Polymorphism and Risk of Schizophrenia  

Yang, So Yung (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center)
Huh, Ik-Soo (Department of Statistics, Seoul National University)
Cho, Eun Young (Center for Clinical Research, Samsung Biomedical Research Institute)
Choi, Mi Ji (Center for Clinical Research, Samsung Biomedical Research Institute)
Park, Taesung (Department of Statistics, Seoul National University)
Lee, Yu-Sang (Yong-In Mental Hospital)
Hong, Kyung Sue (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center)
Publication Information
Korean Journal of Biological Psychiatry / v.22, no.4, 2015 , pp. 173-178 More about this Journal
Abstract
Objectives Previous genome-wide association studies have indicated the association between ankyrin 3 (ANK3) and the vulnerability of schizophrenia. We investigated the association between single nucleotide polymorphisms (SNPs) covering the whole ANK3 locus and schizophrenia in the Korean population. Methods The study subjects were 582 patients with schizophrenia and 502 healthy controls. Thirty-eight tag SNPs on ANK3 and five additional SNPs showing significant association with schizophrenia in previous studies were genotyped. Results Three (rs10994181, rs16914791, rs1938526) of 43 SNPs showed a nominally significant association (p < 0.05) with at least one genotype model. But none of these associations remained significant after adjusting for multiple testing errors with Bonferroni's correction. Conclusions We could not identify a significant association between ANK3 and schizophrenia in the Korean population. However, three SNPs showing an association signal with nominal significance need to be investigated in future studies with higher statistical power and more specific phenotype crossing the current diagnostic categories.
Keywords
ANK3; Schizophrenia; Genetic association study;
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