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Relationship between White Matter Changes and Cognitive Dysfunction in the Elderly with Subjective Memory Complaint  

Shin, Eun-Young (Department of Psychiatry, Soonchunhyang University Hospital)
Jung, Han-Yong (Department of Psychiatry, Soonchunhyang University Hospital)
Kim, Yang-Rae (Psychiatric Office, Kim Yang Rae Hue)
Lee, So-Young-Irene (Department of Psychiatry, Soonchunhyang University Hospital)
Kim, Shin-Gyeom (Department of Psychiatry, Soonchunhyang University Hospital)
Publication Information
Korean Journal of Biological Psychiatry / v.18, no.3, 2011 , pp. 141-147 More about this Journal
Abstract
Objectives The purpose of this study is to evaluate the relationship between the severity of white matter changes (WMC), risk factors and cognitive domains, including executive function profiles. Method Forty nine subjects over 55 years with subjective memory complaints were assessed with MRI and neuropsychological tests. The WMC were assessed by MRI T2-FLAIR images and divided into 3 groups of mild vs. moderate vs. severe and 2 groups of mild-moderate vs. severe by using Mantyla's criteria and Fazeka's criteria. The risk factors were examined in hypertension, heart disease history and chemistry Lab. Medical conditions which affect to cognitive dysfunction and definite dementia were also excluded. Results Comparing 3 groups, hypertension was identified as a risk factor of the WMC. Comparing 2 groups, total cholesterol and LDL were identified for as the risk factor of WMC. The severity of WMC was significantly associated with cognitive disturbances and their main effect on cognition was working memory and inhibition. Conclusion The risk factors of the WMC in the elderly were hypertension, hyperlipidemia. The severity of WMC appears to be associated with executive dysfunction in the elderly.
Keywords
White matter changes; Executive function; Cognition; Risk factor;
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1 Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review. Stroke 1997;28:652-659.   DOI   ScienceOn
2 Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993;43:250-260.   DOI
3 Kalaria RN, Kenny RA, Ballard CG, Perry R, Ince P, Polvikoski T. Towards defining the neuropathological substrates of vascular dementia. J Neurol Sci 2004;226:75-80.   DOI
4 Wolf H, Ecke GM, Bettin S, Dietrich J, Gertz HJ. Do white matter changes contribute to the subsequent development of dementia in patients with mild cognitive impairment? A longitudinal study. Int J Geriatr Psychiatry 2000;15:803-812.   DOI   ScienceOn
5 Snowdon DA, Greiner LH, Mortimer JA, Riley KP, Greiner PA, Markesbery WR. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. JAMA 1997;277:813-817.   DOI   ScienceOn
6 O'Connor DW, Pollitt PA, Roth M, Brook PB, Reiss BB. Memory complaints and impairment in normal, depressed, and demented elderly persons identified in a community survey. Arch Gen Psychiatry 1990;47:224-227.   DOI   ScienceOn
7 Bassett SS, Folstein MF. Memory complaint, memory performance, and psychiatric diagnosis: a community study. J Geriatr Psychiatry Neurol 1993;6:105-111.   DOI
8 Gagnon M, Dartigues JF, Mazaux JM, Dequae L, Letenneur L, Giroire JM, et al. Self-reported memory complaints and memory performance in elderly French community residents: results of the PAQUID Research Program. Neuroepidemiology 1994;13:145-154.   DOI   ScienceOn
9 Tobiansky R, Blizard R, Livingston G, Mann A. The Gospel Oak Study stage IV: the clinical relevance of subjective memory impairment in older people. Psychol Med 1995;25:779-786.   DOI
10 Jonker C, Launer LJ, Hooijer C, Lindeboom J. Memory complaints and memory impairment in older individuals. J Am Geriatr Soc 1996;44:44-49.   DOI
11 Blazer DG, Hays JC, Fillenbaum GG, Gold DT. Memory complaint as a predictor of cognitive decline: a comparison of African American and White elders. J Aging Health 1997;9:171-184.   DOI   ScienceOn
12 Green RC, Cupples LA, Go R, Benke KS, Edeki T, Griffith PA, et al. Risk of dementia among white and African American relatives of patients with Alzheimer disease. JAMA 2002;287:329-336.   DOI   ScienceOn
13 Iliffe S, Pealing L. Subjective memory problems. BMJ 2010;340:c1425. doi:10.1136/bmj.c1425.   DOI
14 Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, et al. Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3301 elderly people. The Cardiovascular Health Study. Stroke 1996;27:1274-1282.   DOI   ScienceOn
15 Garde E, Mortensen EL, Krabbe K, Rostrup E, Larsson HB. Relation between age-related decline in intelligence and cerebral whitematter hyperintensities in healthy octogenarians: a longitudinal study. Lancet 2000;356:628-634.   DOI   ScienceOn
16 De Groot JC, De Leeuw FE, Oudkerk M, Van Gijn J, Hofman A, Jolles J, et al. Periventricular cerebral white matter lesions predict rate of cognitive decline. Ann Neurol 2002;52:335-341.   DOI   ScienceOn
17 Prins ND, van Dijk EJ, den Heijer T, Vermeer SE, Jolles J, Koudstaal PJ, et al. Cerebral small-vessel disease and decline in information processing speed, executive function and memory. Brain 2005;128:2034-2041.   DOI   ScienceOn
18 Longstreth WT Jr, Bernick C, Manolio TA, Bryan N, Jungreis CA, Price TR. Lacunar infarcts defined by magnetic resonance imaging of 3660 elderly people: the Cardiovascular Health Study. Arch Neurol 1998;55:1217-1225.   DOI   ScienceOn
19 Kramer JH, Reed BR, Mungas D, Weiner MW, Chui HC. Executive dysfunction in subcortical ischaemic vascular disease. J Neurol Neurosurg Psychiatry 2002;72:217-220.   DOI   ScienceOn
20 Wen HM, Mok VC, Fan YH, Lam WW, Tang WK, Wong A, et al. Effect of white matter changes on cognitive impairment in patients with lacunar infarcts. Stroke 2004;35:1826-1830.   DOI   ScienceOn
21 Sabri O, Ringelstein EB, Hellwig D, Schneider R, Schreckenberger M, Kaiser HJ, et al. Neuropsychological impairment correlates with hypoperfusion and hypometabolism but not with severity of white matter lesions on MRI in patients with cerebral microangiopathy. Stroke 1999;30:556-566.   DOI   ScienceOn
22 Kim TY, Kim S, Sohn JE, Lee EA, Yoo BG, Lee SC, et al. Development of the Korean stroop test and study of the validity and the reliability. J Korean Geriatr Soc 2004;8:233-240.
23 Wahlund LO, Almkvist O, Basun H, Julin P. MRI in successful aging, a 5-year follow-up study from the eighth to ninth decade of life. Magn Reson Imaging 1996;14:601-608.   DOI   ScienceOn
24 Kang Y, Na DL, Hahn S. A validity study on the Korean Mini-Mental State Examination (K-MMSE) in dementia patients. J Korean Neurol Assoc 1997;15:300-308.
25 Kang Y, Kim H, Na DL. Parallel short form of the Korean-Boston Naming Test(K-BNT). J Korean Neurol Assoc 2000;18:144-150.
26 Mantyla R, Aronen HJ, Salonen O, Pohjasvaara T, Korpelainen M, Peltonen T, et al. Magnetic resonance imaging white matter hyperintensities and mechanism of ischemic stroke. Stroke 1999;30:2053-2058.   DOI   ScienceOn
27 Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351-356.   DOI   ScienceOn
28 Schmidt R, Fazekas F, Koch M, Kapeller P, Augustin M, Offenbacher H, et al. Magnetic resonance imaging cerebral abnormalities and neuropsychologic test performance in elderly hypertensive subjects. A case-control study. Arch Neurol 1995;52:905-910.   DOI   ScienceOn
29 Liao D, Cooper L, Cai J, Toole JF, Bryan NR, Hutchinson RG, et al. Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC Study. Atherosclerosis Risk in Communities Study. Stroke 1996;27:2262-2270.   DOI   ScienceOn
30 Awad IA, Johnson PC, Spetzler RF, Hodak JA. Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. Stroke 1986;17:1090-1097.   DOI   ScienceOn
31 Bots ML, van Swieten JC, Breteler MM, de Jong PT, van Gijn J, Hofman A, et al. Cerebral white matter lesions and atherosclerosis in the Rotterdam Study. Lancet 1993;341:1232-1237.   DOI   ScienceOn
32 Reed BR, Eberling JL, Mungas D, Weiner M, Kramer JH, Jagust WJ. Effects of white matter lesions and lacunes on cortical function. Arch Neurol 2004;61:1545-1550.   DOI   ScienceOn
33 Erkinjuntti T. Vascular cognitive deterioration and stroke. Cerebrovasc Dis 2007;24 Suppl 1:189-194.
34 Breteler MM, van Swieten JC, Bots ML, Grobbee DE, Claus JJ, van den Hout JH, et al. Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study. Neurology 1994;44:1246-1252.   DOI   ScienceOn
35 Erkinjuntti T, Ketonen L, Sulkava R, Sipponen J, Vuorialho M, Iivanainen M. Do white matter changes on MRI and CT differentiate vascular dementia from Alzheimer's disease? J Neurol Neurosurg Psychiatry 1987;50:37-42.   DOI
36 Vermeer SE, van Dijk EJ, Koudstaal PJ, Oudkerk M, Hofman A, Clarke R, et al. Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. Ann Neurol 2002;51:285-289.   DOI   ScienceOn
37 Matsui T, Arai H, Yuzuriha T, Yao H, Miura M, Hashimoto S, et al. Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people. Stroke 2001;32:1116-1119.   DOI   ScienceOn
38 Boone KB, Miller BL, Lesser IM, Mehringer CM, Hill-Gutierrez E, Goldberg MA, et al. Neuropsychological correlates of white-matter lesions in healthy elderly subjects. A threshold effect. Arch Neurol 1992;49:549-554.   DOI   ScienceOn
39 Mendez MF, Adams NL, Lewandowski KS. Neurobehavioral changes associated with caudate lesions. Neurology 1989;39:349-354.   DOI
40 Tatemichi TK, Steinke W, Duncan C, Bello JA, Odel JG, Behrens MM, et al. Paramedian thalamopeduncular infarction: clinical syndromes and magnetic resonance imaging. Ann Neurol 1992;32:162-171.   DOI   ScienceOn