Antiviral Activity of Plant-derived Natural Products against Influenza Viruses |
Kim, Seonjeong
(Department of Biological Sciences and Biotechnology Major in Bio-Vaccine engineering, Andong National University)
Kim, Yewon (Department of Biological Sciences and Biotechnology Major in Bio-Vaccine engineering, Andong National University) Kim, Ju Won (Department of Biological Sciences and Biotechnology Major in Bio-Vaccine engineering, Andong National University) Hwang, Yu-bin (Department of Biological Sciences and Biotechnology Major in Bio-Vaccine engineering, Andong National University) Kim, Seong Hyeon (Department of Biological Sciences and Biotechnology Major in Bio-Vaccine engineering, Andong National University) Jang, Yo Han (Department of Biological Sciences and Biotechnology Major in Bio-Vaccine engineering, Andong National University) |
1 | Eriksson, B., Helgstrand, E., Johansson, N. G., Larsson, A., Misiorny, A., Noren, J. O., Philipson, L., Stenberg, K., Stening, G., Stridh, S. and Oberg, B. 1977. Inhibition of influenza virus ribonucleic acid polymerase by ribavirin triphosphate. Antimicrob. Agents Chemother. 11, 946-951. DOI |
2 | Ha, T. K. Q. and Lee, B. W. 2020. Antiviral activities of compounds isolated from Pinus densiflora (pine tree) against the influenza A virus. Biomelecules 10, 711. DOI |
3 | Hayashi, K., Hayashi, H., Hiraoka, N. and Ikeshiro, Y. 1997. Inhibitory activity of soyasaponin II on virus replication in vitro. Planta Med. 63, 102-105. DOI |
4 | Joo, Y. H., Lee, Y. G., Lim, Y., Jeon, H., Kim, E. H., Choi, J., Hong, W., Jeon, H., Ahrweiler, M., Kim, H., Kang, S. C. and Seo, Y. J. 2022. Potent antiviral activity of the extract of Elaeocarpus sylvestris against influenza A virus in vitro and in vivo. Phytomedicine 97, 153892. DOI |
5 | Kiso, M., Takahashi, K., Sakai-Tagawa, Y., Shinya, K., Sakabe, S., Le, Q. M., Ozawa, M., Furuta, Y. and Kawaoka, Y. 2010. T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. USA. 107, 882-887. DOI |
6 | Zhao, X., Zhao, L., Zhao, Y., Huang, K., Gong, W., Yang, Y., Zhao, L., Xia, X., Li, Z., Sheng, F., Du, X. and Jin, M. 2021. 3-Indoleacetonitrile is highly effective in treating influenza A virus infection in vitro and in vivo. Viruses 13, 1433. DOI |
7 | Lai, Y., Yan, Y., Liao, S., Li, Y., Ye, Y., Liu, N., Zhao, F. and Xu, P. 2020. 3D-quantitative structure-activity relationship and antiviral effects of curcumin derivatives as potent inhibitors of influenza H1N1 neuraminidase. Arch. Pharm. Res. 43, 489-502. DOI |
8 | Wille, M. and Holmes, E. C. 2020. The ecology and evolution of influenza viruses. Cold Spring Harb. Perspect. Med. 10, a038489. DOI |
9 | Yan, H., Wang, H., Ma, L., Ma, X., Yin, J., Wu, S., Huang, H. and Li, Y. 2018. Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway. Virol. J. 15, 88. DOI |
10 | Yan, W., Zheng, C., He, J., Zhang, W., Huang, X. A., Li, X., Wang, Y. and Wang, X. 2018. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Int. J. Mol. Med. 42, 2776-2792. |
11 | Yu, C. H., Yu, W. Y., Fang, J., Zhang, H. H., Ma, Y., Yu, B., Wu, F. and Wu, X. N. 2016. Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice. J. Ethnopharmacol. 179, 146-155. DOI |
12 | Wilasrusmee, C., Kittur, S., Siddiqui, J., Bruch, D., Wilasrusmee, S. and Kittur, D. S. 2002. In vitro immunomodulatory effects of ten commonly used herbs on murine lymphocytes. J. Altern. Complement. Med. 8, 467-475. DOI |
13 | Heo, Y., Cho, Y., Ju, K. S., Cho, H., Park, K. H., Choi, H., Yoon, J. K., Moon, C. and Kim, Y. B. 2018. Antiviral activity of Poncirus trifoliata seed extract against oseltamivir-resistant influenza virus. J. Microbiol. 56, 586-592. DOI |
14 | Kuzuhara, T., Iwai, Y., Takahashi, H., Hatakeyama, D. and Echigo, N. 2009. Green tea catechins inhibit the endonuclease activity of influenza A virus RNA polymerase. PLoS Curr. 1, Rrn1052. |
15 | Muchtaridi, M., Nuwarda, R. F., Ikram, E. H. K., Abdul Rahim, A. S., Gazzali, A. M. and Wahab, H. A. 2022. Neuraminidase inhibitor of garcinia atroviridis L. fruits and leaves using partial purification and molecular characterization. Molecules 27, 949. DOI |
16 | Sharabi, S., Drori, Y., Micheli, M., Friedman, N., Orzitzer, S., Bassal, R., Glatman-Freedman, A., Shohat, T., Mendelson, E., Hindiyeh, M. and Mandelboim, M. 2016. Epidemiological and virological vharacterization of influenza B virus infections. PLoS One 11, e0161195-e0161195. DOI |
17 | Fang, W., Yang, Y. J., Guo, B. L. and Cen, S. 2017. Anti-influenza triterpenoid saponins (saikosaponins) from the roots of Bupleurum marginatum var. stenophyllum. Bioorg. Med. Chem. Lett. 27, 1654-1659. DOI |
18 | Zhou, B., Wang, L., Liang, Y., Li, J. and Pan, X. 2021. Arctiin suppresses H9N2 avian influenza virus-mediated inflammation via activation of Nrf2/HO-1 signaling. BMC Complement. Med. Ther. 21, 289. DOI |
19 | Haqqi, T. M., Anthony, D. D., Gupta, S., Ahmad, N., Lee, M. S., Kumar, G. K. and Mukhtar, H. 1999. Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. Proc. Natl. Acad. Sci. USA. 96, 4524-4529. DOI |
20 | Hayashi, K., Sagesaka, Y. M., Suzuki, T. and Suzuki, Y. 2000. Inactivation of human type A and B influenza viruses by tea-seed aaponins. Biosci. Biotechnol. Biochem. 64, 184-186. DOI |
21 | Huang, C. T., Hung, C. Y., Hseih, Y. C., Chang, C. S., Velu, A. B., He, Y. C., Huang, Y. L., Chen, T. A., Chen, T. C., Lin, C. Y., Lin, Y. C., Shih, S. R. and Dutta, A. 2019. Effect of aloin on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza. Phytomedicine 64, 152904. DOI |
22 | Kim, M., Kim, S. Y., Lee, H. W., Shin, J. S., Kim, P., Jung, Y. S., Jeong, H. S., Hyun, J. K. and Lee, C. K. 2013. Inhibition of influenza virus internalization by (-)-epigallocatechin-3-gallate. Antiviral Res. 100, 460-472. DOI |
23 | Koch, C., Reichling, J., Schneele, J. and Schnitzler, P. 2008. Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine 15, 71-78. DOI |
24 | Wang, S., Li, Z., Ma, Y., Liu, Y., Lin, C. C., Li, S., Zhan, J. and Ho, C. T. 2021. Immunomodulatory effects of green tea polyphenols. Molecules 26, 3755. DOI |
25 | Lee, Y. H., Jang, Y. H., Byun, Y. H., Cheong, Y., Kim, P., Lee, Y. J., Lee, Y. J., Sung, J. M., Son, A., Lee, H. M., Lee, J., Yang, S. W., Song, J. M. and Seong, B. L. 2017. Green tea catechin-inactivated viral vaccine platform. Front. Microbiol. 8, 2469. DOI |
26 | Li, P., Du, R., Chen, Z., Wang, Y., Zhan, P., Liu, X., Kang, D., Chen, Z., Zhao, X., Wang, L., Rong, L. and Cui, Q. 2021. Punicalagin is a neuraminidase inhibitor of influenza viruses. J. Med. Virol. 93, 3465-3472. DOI |
27 | Elebeedy, D., Badawy, I., Elmaaty, A. A., Saleh, M. M., Kandeil, A., Ghanem, A., Kutkat, O., Alnajjar, R., Abd El Maksoud, A. I. and Al-Karmalawy, A. A. 2022. In vitro and computational insights revealing the potential inhibitory effect of Tanshinone IIA against influenza A virus. Comput. Biol. Med. 141, 105149. DOI |
28 | Zhang, L., Chen, J., Ke, C., Zhang, H., Zhang, S., Tang, W., Liu, C., Liu, G., Chen, S., Hu, A., Sun, W., Xiao, Y., Liu, M. and Chen, X. 2020. Ethanol extract of Caesalpinia decapetala inhibits influenza virus infection in vitro and in vivo. Viruses 12, 557. DOI |
29 | Akram, M., Tahir, I. M., Shah, S. M. A., Mahmood, Z., Altaf, A., Ahmad, K., Munir, N., Daniyal, M., Nasir, S. and Mehboob, H. 2018. Antiviral potential of medicinal plants against HIV, HSV, influenza, hepatitis, and coxsackievirus: A systematic review. Phytother. Res. 32, 811-822. DOI |
30 | Hossan, M. S., Fatima, A., Rahmatullah, M., Khoo, T. J., Nissapatorn, V., Galochkina, A. V., Slita, A. V., Shtro, A. A., Nikolaeva, Y., Zarubaev, V. V. and Wiart, C. 2018. Antiviral activity of Embelia ribes Burm. f. against influenza virus in vitro. Arch. Virol. 163, 2121-2131. DOI |
31 | Watson, J. L., Vicario, M., Wang, A., Moreto, M. and McKay, D. M. 2005. Immune cell activation and sub- sequent epithelial dysfunction by Staphylococcus enterotoxin B is attenuated by the green tea polyphenol (-)-epigallocatechin gallate. Cell. Immunol. 237, 7-16. DOI |
32 | Chang, J. S., Wang, K. C., Yeh, C. F., Shieh, D. E. and Chiang, L. C. 2013. Fresh ginger (Zingiber officinale) has anti-viral activity against human respiratory syncytial virus in human respiratory tract cell lines. J. Ethnopharmacol. 145, 146-151. DOI |
33 | Patel, S., Faraj, Y., Duso, D. K., Reiley, W. W., Karlsson, E. A., Schultz-Cherry, S. and Vajdy, M. 2017. Comparative safety and efficacy profile of a novel oil in water vaccine adjuvant comprising vitamins A and E and a catechin in protective anti-influenza immunity. Nutrients 9, 516. DOI |
34 | Choi, H. J. 2018. Chemical constituents of essential oils possessing anti-influenza A/WS/33 virus activity. Osong Public Health Res. Perspect. 9, 348-353. DOI |
35 | Chen, F., Yang, L., Huang, Y., Chen, Y., Sang, H., Duan, W. and Yang, J. 2020. Isocorilagin, isolated from Canarium album (Lour.) Raeusch, as a potent neuraminidase inhibitor against influenza A virus. Biochem. Biophys. Res. Commun. 523, 183-189. DOI |
36 | Wang, Y., Zhou, B., Lu, J., Chen, Q., Ti, H., Huang, W., Li, J., Yang, Z., Jiang, Z. and Wang, X. 2017. Inhibition of influenza virus via a sesquiterpene fraction isolated from Laggera pterodonta by targeting the NF-κB and p38 pathways. BMC Complement. Altern. Med. 17, 25. DOI |
37 | Ahn, S. C., Kim, G. Y., Kim, J. H., Baik, S. W., Han, M. K., Lee, H. J., Moon, D. O., Lee, C. M., Kang, J. H., Kim, B. H., Oh, Y. H. and Park, Y. M. 2004. Epigallocatechin-3-gallate, constituent of green tea, suppresses the LPS-induced phenotypic and functional maturation of murine dendritic cells through inhibition of mitogen-activated protein kinases and NF-kappaB. Biochem. Biophys. Res. Commun. 313, 148-155. DOI |
38 | Ardebili, A., Pouriayevali, M. H., Aleshikh, S., Zahani, M., Ajorloo, M., Izanloo, A., Siyadatpanah, A., Razavi Nikoo, H., Wilairatana, P. and Coutinho, H. D. M. 2021. Antiviral therapeutic potential of curcumin: An update. Molecules 26, 6994. DOI |
39 | Bae, S., Kang, S. C. and Song, Y. J. 2017. Inhibition of human cytomegalovirus immediate-early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro. BMC Complement. Altern. Med. 17, 428-428. DOI |
40 | Chen, D. Y., Shien, J. H., Tiley, L., Chiou, S. S., Wang, S. Y., Chang, T. J., Lee, Y. J., Chan, K. W. and Hsu, W. L. 2010. Curcumin inhibits influenza virus infection and haemagglutination activity. Food Chem. 119, 1346-1351. DOI |
41 | Cheong, Y., Kim, M., Ahn, J., Oh, H., Lim, J., Chae, W., Yang, S. W., Kim, M. S., Yu, J. E., Byun, S., Jang, Y. H. and Seong, B. L. 2021. Epigallocatechin-3-gallate as a novel vaccine adjuvant. Front. Immunol. 12, 769088. DOI |
42 | Chavan, R. D., Shinde, P., Girkar, K., Madage, R. and Chowdhary, A. 2016. Assessment of anti-influenza activity and hemagglutination inhibition of Plumbago indica and Allium sativum extracts. Pharmacognosy Res. 8, 105-111. DOI |
43 | Li, P., Du, R., Wang, Y., Hou, X., Wang, L., Zhao, X., Zhan, P., Liu, X., Rong, L. and Cui, Q. 2020. Identification of chebulinic acid and chebulagic acid as novel influenza viral neuraminidase inhibitors. Front. Microbiol. 11, 182. DOI |
44 | Li, Z., Li, L., Zhou, H., Zeng, L., Chen, T., Chen, Q., Zhou, B., Wang, Y., Chen, Q., Hu, P. and Yang, Z. 2017. Radix isatidis polysaccharides inhibit influenza a virus and influenza A virus-induced inflammation via suppression of host TLR3 signaling in vitro. Molecules 22, 116. DOI |
45 | Ming, L., Li, Z., Li, X., Tang, L. and He, G. 2021. Antiviral activity of diallyl trisulfide against H9N2 avian influenza virus infection in vitro and in vivo. Virol. J. 18, 171. DOI |
46 | Chen, J., Duan, M., Zhao, Y., Ling, F., Xiao, K., Li, Q., Li, B., Lu, C., Qi, W., Zeng, Z., Liao, M., Liu, Y. and Chen, W. 2015. Saikosaponin A inhibits influenza A virus replication and lung immunopathology. Oncotarget 6, 42541-42556. DOI |
47 | Cho, W. K. and Ma, J. Y. 2022. Antiviral activity of Epimedium koreanum Nakai water extract against influenza viruses. Biomed. Pharmacother. 146, 112581. DOI |
48 | Li, M., Wang, Y., Jin, J., Dou, J., Guo, Q., Ke, X., Zhou, C. and Guo, M. 2021. Inhibitory activity of honeysuckle extracts against influenza A virus in vitro and in vivo. Virol. Sin. 36, 490-500. DOI |
49 | Mair, C. E., Grienke, U., Wilhelm, A., Urban, E., Zehl, M., Schmidtke, M. and Rollinger, J. M. 2018. Anti-influenza triterpene saponins from the bark of Burkea africana. J. Nat. Prod. 81, 515-523. DOI |
50 | Choi, J.-G., Kim, Y. S., Kim, J. H. and Chung, H. S. 2019. Antiviral activity of ethanol extract of Geranii Herba and its components against influenza viruses via neuraminidase inhibition. Sci. Rep. 9, 12132-12132. DOI |
51 | De Clercq, E. and Li, G. 2016. Approved antiviral drugs over the past 50 years. Clin. Microbiol. Rev. 29, 695-747. DOI |
52 | Denyer, C. V., Jackson, P., Loakes, D. M., Ellis, M. R. and Young, D. A. 1994. Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale). J. Nat. Prod. 57, 658-662. DOI |
53 | Ehrhardt, C., Hrincius, E. R., Korte, V., Mazur, I., Droeb- ner, K., Poetter, A., Dreschers, S., Schmolke, M., Planz, O. and Ludwig, S. 2007. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res. 76, 38-47. DOI |
54 | Gupta, T., Kataria, R. and Sardana, S. 2022. A comprehensive review on current perspectives of flavonoids as antimicrobial agent. Curr. Top. Med. Chem. 22, 425-434. DOI |
55 | Haidari, M., Ali, M., Ward Casscells, S. 3rd. and Madjid, M. 2009. Pomegranate (Punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir. Phytomedicine 16, 1127-1136. DOI |
56 | Song, G., Yang, S., Zhang, W., Cao, Y., Wang, P., Ding, N., Zhang, Z., Guo, Y. and Li, Y. 2009. Discovery of the first series of small molecule H5N1 entry inhibitors. J. Med. Chem. 52, 7368-7371. DOI |
57 | Nie, L. X., Wu, Y. L., Dai, Z. and Ma, S. C. 2020. Antiviral activity of Isatidis Radix derived glucosinolate isomers and their breakdown products against influenza A in vitro/ovo and mechanism of action. J. Ethnopharmacol. 251, 112550. DOI |
58 | Sarker, A., Gu, Z., Mao, L., Ge, Y., Hou, D., Fang, J., Wei, Z. and Wang, Z. 2022. Influenza-existing drugs and treatment prospects. Eur. J. Med. Chem. 232, 114189. DOI |
59 | Singh, B. N., Shankar, S. and Srivastava, R. K. 2011. Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochem. Pharmacol. 82, 1807-1821. DOI |
60 | Sun, X., Zhang, L., Cao, Y., Li, J., Atanasov, A. G. and Huang, L. 2020. Anti-neuraminidase activity of chemical constituents of Balanophora involucrata. Biomed. Chromatography. 34, e4949. |
61 | von Itzstein, M., Wu, W. Y., Kok, G. B., Pegg, M. S., Dyason, J. C., Jin, B., Van Phan, T., Smythe, M. L., White, H. F. and Oliver, S. W., et al. 1993. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363, 418-423. DOI |
62 | Wang, J., Prinz, R. A., Liu, X. and Xu, X. 2020. In vitro and in vivo antiviral activity of gingerenone A on influenza A virus is mediated by targeting Janus Kinase 2. Viruses 12, 1141. DOI |
63 | Shi, Y., Zhang, B., Lu, Y., Qian, C., Feng, Y., Fang, L., Ding, Z. and Cheng, D. 2017. Antiviral activity of phenanthrenes from the medicinal plant Bletilla striata against influenza A virus. BMC Complement. Altern. Med. 17, 273. DOI |
64 | Musial, C., Kuban-Jankowska, A. and Gorska-Ponikowska, M. 2020. Beneficial properties of green tea catechins. Int. J. Mol. Sci. 21, 1744. DOI |
65 | Li, S., Jia, X., Shen, X., Wei, Z., Jiang, Z., Liao, Y., Guo, Y., Zheng, X., Zhong, G. and Song, G. 2017. Structure-activity relationships of 3-O-β-chacotriosyl oleanic acid derivatives as entry inhibitors for highly pathogenic H5N1 influenza virus. Bioorg. Med. Chem. 25, 4384-4396. DOI |
66 | Rouf, R., Uddin, S. J., Sarker, D. K., Islam, M. T., Ali, E. S., Shilpi, J. A., Nahar, L., Tiralongo, E. and Sarker, S. D. 2020. Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: a systematic update of pre-clinical and clinical data. Trends Food Sci. Technol. 104, 219-234. DOI |
67 | Song, J. M., Lee, K. H. and Seong, B. L. 2005. Antiviral effect of catechins in green tea on influenza virus. Antiviral Res. 68, 66-74. DOI |
68 | Wang, H. X., Zeng, M. S., Ye, Y., Liu, J. Y. and Xu, P. P. 2021. Antiviral activity of puerarin as potent inhibitor of influenza virus neuraminidase. Phytother. Res. 35, 324-336. DOI |
69 | Wang, Y. Q., Li, Q. S., Zheng, X. Q., Lu, J. L. and Liang, Y. R. 2021. Antiviral effects of green tea EGCG and its potential application against COVID-19. Molecules 26, 3962. DOI |
70 | Pu, X., Ren, J., Ma, X., Liu, L., Yu, S., Li, X. and Li, H. 2015. Polyphylla saponin I has antiviral activity against influenza A virus. Int. J. Clin. Exp. Med. 8, 18963-18971. |
71 | Rockman, S., Taylor, B., McCauley, J. W., Barr, I. G., Longstaff, R. and Bahra, R. 2022. Global pandemic preparedness: optimizing our capabilities and the influenza experience. Vaccines 10, 589. DOI |
72 | Ling, J. X., Wei, F., Li, N., Li, J. L., Chen, L. J., Liu, Y. Y., Luo, F., Xiong, H. R., Hou, W. and Yang, Z. Q. 2012. Amelioration of influenza virus-induced reactive oxygen species formation by epigallocatechin gallate derived from green tea. Acta Pharmacol. Sin. 33, 1533-1541. DOI |
73 | Khan, A., Ali, N. H., Santercole, V., Paglietti, B., Rubino, S., Kazmi, S. U. and Farooqui, A. 2016. Camellia sinensis mediated enhancement of humoral immunity to particulate and Non-particulate Antigens. Phytother. Res. 30, 41-48. DOI |
74 | Perera, A., Ton, S. H. and Palanisamy, U. D. 2015. Per- spectives on geraniin, a multifunctional natural bioactive compound. Trends Food Sci. Technol. 44, 243-257. DOI |
75 | Praditya, D., Kirchhoff, L., Bruning, J., Rachmawati, H., Steinmann, J. and Steinmann, E. 2019. Anti-infective properties of the golden spice curcumin. Front. Microbiol. 10, 912. DOI |
76 | Razonable, R. R. 2011. Antiviral drugs for viruses other than human immunodeficiency virus. Mayo Clin. Proc. 86, 1009-1026. DOI |
77 | Nimmerjahn, F., Dudziak, D., Dirmeier, U., Hobom, G., Riedel, A., Schlee, M., Staudt, L. M., Rosenwald, A., Behrends, U., Bornkamm, G. W. and Mautner, J. 2004. Active NF-kappaB signalling is a prerequisite for influenza virus infection. J. Gen. Virol. 85, 2347-2356. DOI |
78 | Welsby, I., Detienne, S., N'Kuli, F., Thomas, S., Wouters, S., Bechtold, V., De Wit, D., Gineste, R., Reinheckel, T., Elouahabi, A., Courtoy, P. J., Didierlaurent, A. M. and Goriely, S. 2016. Lysosome-dependent activation of human dendritic cells by the vaccine adjuvant QS-21. Front. Immunol. 7, 663. |
79 | Choi, J. G., Lee, H., Kim, Y. S., Hwang, Y. H., Oh, Y. C., Lee, B., Moon, K. M., Cho, W. K. and Ma, J. Y. 2019. Aloe vera and its components inhibit influenza A virus-induced autophagy and replication. Am. J. Chin. Med. 47, 1307-1324. DOI |
80 | Ding, N., Chen, Q., Zhang, W., Ren, S., Guo, Y. and Li, Y. 2012. Structure-activity relationships of saponin derivatives: a series of entry inhibitors for highly pathogenic H5N1 influenza virus. Eur. J. Med. Chem. 53, 316-326. DOI |
81 | Woolhouse, M., Scott, F., Hudson, Z., Howey, R. and Chase-Topping, M. 2012. Human viruses: discovery and emergence. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 367, 2864-2871. DOI |
82 | Yen, H. L. 2016. Current and novel antiviral strategies for influenza infection. Curr. Opin. Virol. 18, 126-134. DOI |
83 | Jang, Y. H. and Seong, B. L. 2019. The quest for a truly universal influenza vaccine. Front. Cell. Infect. Microbiol. 9, 344-344. DOI |
84 | Lee, B. W., Ha, T. K. Q., Cho, H. M., An, J. P., Kim, S. K., Kim, C. S., Kim, E. and Oh, W. K. 2020. Antiviral activity of furanocoumarins isolated from Angelica dahurica against influenza a viruses H1N1 and H9N2. J. Ethnopharmacol. 259, 112945. DOI |