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http://dx.doi.org/10.5352/JLS.2022.32.5.368

Anti-inflammatory and Anti-allergic Effects of Lentinula edodes Extract by UVIrradiation  

Hwang, Mi Sun (Department of Pharmaceutical Science and Technology, Kyungsung University)
Pyo, Jaesung (Department of Pharmacy, Kyungsung University)
Kim, Hyun Jin (R&D Center, Naturetch Co., Ltd.)
Do, Sun Gil (R&D Center, Naturetch Co., Ltd.)
Song, Il Dae (Department of Pharmaceutical Science and Technology, Kyungsung University)
Kim, Kang Min (Department of Pharmaceutical Science and Technology, Kyungsung University)
Publication Information
Journal of Life Science / v.32, no.5, 2022 , pp. 368-374 More about this Journal
Abstract
In this study, the effects of UV irradiation-enhanced ergocalciferol (vitamin D2) content containing Lentinula edodes extract on inflammation and allergic responses were investigated in vitro. The anti-inflammatory and anti-allergic effects of the mushroom extract were tested by estimating the cytokine secretions, such as TNF-α, IL-6, and IL-1β in LPS-activated macrophages (RAW 264.7), or histamine release in PMA and A23187-activated mast cells (RBL-2H3). Under the condition of macrophage activation with LPS, mushroom extract significantly reduced the secretions of pro-inflammatory cytokines, TNF-α and IL-6, and their mRNA expression also matched the observation. The current mushroom extract also significantly reduced the amount of mast cell degranulation-induced histamine secretion from PMA- and A23187-treated mast cells as well as the reduced secretion of IL-4. These results suggest that mushroom extract, which has increased ergocalciferol content by UV irradiation, inhibits the expression of cytokines in inflammation and allergic reactions; therefore, it can be used effectively for the prevention and treatment of inflammatory and allergic diseases.
Keywords
Anti-allergy; anti-inflammation; cytokine; Lentinula edodes; vitamin D;
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