1 |
Lee, J. E., Cho, Y. W., Deng, C. X. and Ge, K. 2020. MLL3/MLL4-associated PAGR1 regulates adipogenesis by controlling induction of C/EBPβ and C/EBPδ. Mol. Cell. Biol. 40, e00209-20.
|
2 |
Martinez-Botas, J., Anderson, J. B., Tessier, D., Lapillonne, A., Chang, B. H., Quast, M. J., Gorenstein, D., Chen, K. H. and Chan, L. 2000. Absence of perilipin results in leanness and reverses obesity in Lepr (db/db) mice. Nat. Genet. 26, 474-479.
DOI
|
3 |
Park, Y. K., Wang, L., Giampietro, A., Lai, B., Lee, J. E. and Ge, K. 2017. Distinct roles of transcription factors KLF4, Krox20, and peroxisome proliferator-activated receptor gamma in adipogenesis. Mol. Cell. Biol. 37, e00554-16.
|
4 |
Takeuchi, K. and Reue, K. 2009. Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis. Am. J. Physiol. Endocrinol. Metab. 296, E1195-1209.
DOI
|
5 |
Wang, B. and Tontonoz, P. 2018. Liver X receptors in lipid signalling and membrane homeostasis. Nat. Rev. Endocrinol. 14, 452-463.
DOI
|
6 |
Strable, M. S. and Ntambi, J. M. 2010. Genetic control of de novo lipogenesis: role in diet-induced obesity. Crit. Rev. Biochem. Mol. Biol. 45, 199-214.
DOI
|
7 |
Rosen, E. D., Hsu, C. H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J. and Spiegelman, B. M. 2002. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 16, 22-26.
DOI
|
8 |
Schultz, J. R., Tu, H., Luk, A., Repa, J. J., Medina, J. C., Li, L., Schwendner, S., Wang, S., Thoolen, M., Mangelsdorf, D. J., Lustig, K. D. and Shan, B. 2000. Role of LXRs in control of lipogenesis. Genes Dev. 14, 2831-2838.
DOI
|
9 |
Song, Z., Xiaoli, A. M. and Yang, F. 2018. Regulation and metabolic significance of de novo lipogenesis in adipose tissues. Nutrients 10, 1383.
DOI
|
10 |
Witte, N., Muenzner, M., Rietscher, J., Knauer, M., Heidenreich, S., Nuotio-Antar, A. M., Graef, F. A., Fedders, R., Tolkachov, A., Goehring, I. and Schupp, M. 2015. The glucose sensor ChREBP links de novo lipogenesis to PPA Rgamma activity and adipocyte differentiation. Endocrinology 156, 4008-4019.
DOI
|
11 |
Gesta, S., Tseng, Y. H. and Kahn, C. R. 2007. Developmental origin of fat: tracking obesity to its source. Cell 131, 242-256.
DOI
|
12 |
Allen, B. L. and Taatjes, D. J. 2015. The Mediator complex: a central integrator of transcription. Nat. Rev. Mol. Cell. Biol. 16, 155-166.
DOI
|
13 |
Cortes, V. A., Curtis, D. E., Sukumaran, S., Shao, X., Parameswara, V., Rashid, S., Smith, A. R., Ren, J., Esser, V., Hammer, R. E., Agarwal, A. K., Horton, J. D. and Garg, A. 2009. Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy. Cell Metab. 9, 165-176.
DOI
|
14 |
Garg, A. 2004. Acquired and inherited lipodystrophies. N. Engl. J. Med. 350, 1220-1234.
DOI
|
15 |
Sanchez-Gurmaches, J., Tang, Y., Jespersen, N. Z., Wallace, M., Martinez Calejman, C., Gujja, S., Li, H., Edwards, Y. J. K., Wolfrum, C., Metallo, C. M., Nielsen, S., Scheele, C. and Guertin, D. A. 2018. Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis. Cell Metab. 27, 195-209 e196.
DOI
|
16 |
Shimano, H., Horton, J. D., Shimomura, I., Hammer, R. E., Brown, M. S. and Goldstein, J. L. 1997. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells. J. Clin. Invest. 99, 846-854.
DOI
|
17 |
Shimano, H. and Sato, R. 2017. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nat. Rev. Endocrinol. 13, 710-730.
DOI
|
18 |
Agarwal, A. K., Arioglu, E., De Almeida, S., Akkoc, N., Taylor, S. I., Bowcock, A. M., Barnes, R. I. and Garg, A. 2002. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat. Genet. 31, 21-23.
DOI
|
19 |
Vijayakumar, A., Aryal, P., Wen, J., Syed, I., Vazirani, R. P., Moraes-Vieira, P. M., Camporez, J. P., Gallop, M. R., Perry, R. J., Peroni, O. D., Shulman, G. I., Saghatelian, A., McGraw, T. E. and Kahn, B. B. 2017. Absence of carbohydrate response element binding protein in adipocytes causes systemic insulin resistance and impairs glucose transport. Cell Rep. 21, 1021-1035.
DOI
|
20 |
Youn, D. Y., Xiaoli, A. M., Kwon, H., Yang, F. and Pessin, J. E. 2019. The subunit assembly state of the Mediator complex is nutrient-regulated and is dysregulated in a genetic model of insulin resistance and obesity. J. Biol. Chem. 294, 9076-9083.
DOI
|
21 |
Jang, Y., Park, Y. K., Lee, J. E., Wan, D., Tran, N., Gavrilova, O. and Ge, K. 2021. MED1 is a lipogenesis coactivator required for postnatal adipose expansion. Genes Dev. 35, 713-728.
DOI
|
22 |
Yang, F., Vought, B. W., Satterlee, J. S., Walker, A. K., Jim Sun, Z. Y., Watts, J. L., DeBeaumont, R., Saito, R. M., Hyberts, S. G., Yang, S., Macol, C., Iyer, L., Tjian, R., van den Heuvel, S., Hart, A. C., Wagner, G. and Naar, A. M. 2006. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 442, 700-704.
DOI
|
23 |
Horton, J. D., Shimomura, I., Ikemoto, S., Bashmakov, Y. and Hammer, R. E. 2003. Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver. J. Biol. Chem. 278, 36652-36660.
DOI
|
24 |
Jang, Y., Broun, A., Wang, C., Park, Y. K., Zhuang, L., Lee, J. E., Froimchuk, E., Liu, C. and Ge, K. 2019. H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development. Nucleic Acids Res. 47, 607-620.
DOI
|
25 |
Lefterova, M. I. and Lazar, M. A. 2009. New developments in adipogenesis. Trends Endocrinol. Metab. 20, 107-114.
DOI
|
26 |
Malik, S. and Roeder, R. G. 2010. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat. Rev. Genet. 11, 761-772.
DOI
|
27 |
Nuotio-Antar, A. M., Poungvarin, N., Li, M., Schupp, M., Mohammad, M., Gerard, S., Zou, F. and Chan, L. 2015. FABP4-Cre mediated expression of constitutively active ChREBP protects against obesity, fatty liver, and insulin resistance. Endocrinology 156, 4020-4032.
DOI
|
28 |
Gandotra, S., Le Dour, C., Bottomley, W., Cervera, P., Giral, P., Reznik, Y., Charpentier, G., Auclair, M., Delepine, M., Barroso, I., Semple, R. K., Lathrop, M., Lascols, O., Capeau, J., O'Rahilly, S., Magre, J., Savage, D. B. and Vigouroux, C. 2011. Perilipin deficiency and autosomal dominant partial lipodystrophy. N. Engl. J. Med. 364, 740-748.
DOI
|
29 |
Beaven, S. W., Matveyenko, A., Wroblewski, K., Chao, L., Wilpitz, D., Hsu, T. W., Lentz, J., Drew, B., Hevener, A. L. and Tontonoz, P. 2013. Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance. Cell Metab. 18, 106-117.
DOI
|
30 |
Berry, D. C., Stenesen, D., Zeve, D. and Graff, J. M. 2013. The developmental origins of adipose tissue. Development 140, 3939-3949.
DOI
|
31 |
Ge, K. 2012. Epigenetic regulation of adipogenesis by histone methylation. Biochim. Biophys. Acta 1819, 727-732.
DOI
|
32 |
Ge, K., Guermah, M., Yuan, C. X., Ito, M., Wallberg, A. E., Spiegelman, B. M. and Roeder, R. G. 2002. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 417, 563-567.
DOI
|
33 |
Grant, R. W. and Dixit, V. D. 2015. Adipose tissue as an immunological organ. Obesity (Silver Spring) 23, 512-518.
DOI
|
34 |
Dib, L., Bugge, A. and Collins, S. 2014. LXRalpha fuels fatty acid-stimulated oxygen consumption in white adipocytes. J. Lipid Res. 55, 247-257.
DOI
|
35 |
Herman, M. A., Peroni, O. D., Villoria, J., Schon, M. R., Abumrad, N. A., Bluher, M., Klein, S. and Kahn, B. B. 2012. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature 484, 333-338.
DOI
|
36 |
Poungvarin, N., Chang, B., Imamura, M., Chen, J., Moolsuwan, K., Sae-Lee, C., Li, W. and Chan, L. 2015. Genomewide analysis of ChREBP binding sites on male mouse liver and white adipose chromatin. Endocrinology 156, 1982-1994.
DOI
|
37 |
Park, Y. K. and Ge, K. 2017. Glucocorticoid receptor accelerates, but is dispensable for, adipogenesis. Mol. Cell. Biol. 37, e00260-16.
|
38 |
Pearce, J. 1983. Fatty acid synthesis in liver and adipose tissue. Proc. Nutr. Soc. 42, 263-271.
DOI
|
39 |
Rosen, E. D. and MacDougald, O. A. 2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7, 885-896.
DOI
|
40 |
Ito, K., Schneeberger, M., Gerber, A., Jishage, M., Marchildon, F., Maganti, A. V., Cohen, P., Friedman, J. M. and Roeder, R. G. 2021. Critical roles of transcriptional coactivator MED1 in the formation and function of mouse adipose tissues. Genes Dev. 35, 729-748.
DOI
|
41 |
Zhao, X., Feng, D., Wang, Q., Abdulla, A., Xie, X. J., Zhou, J., Sun, Y., Yang, E. S., Liu, L. P., Vaitheesvaran, B., Bridges, L., Kurland, I. J., Strich, R., Ni, J. Q., Wang, C., Ericsson, J., Pessin, J. E., Ji, J. Y. and Yang, F. 2012. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J. Clin. Invest. 122, 2417-2427.
DOI
|