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http://dx.doi.org/10.5352/JLS.2021.31.4.430

Sesquiterpene Lactones: A Review of Biological Activities  

Karadeniz, Fatih (Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University)
Oh, Jung Hwan (Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University)
Kong, Chang-Suk (Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University)
Publication Information
Journal of Life Science / v.31, no.4, 2021 , pp. 430-441 More about this Journal
Abstract
Sesquiterpene lactones (STLs) are terpenoids found mostly in the Asteraceae family and are known for their strong cytotoxic properties, among other notable bioactivities. Some STLs, such as artemisinin and mipsagargin, are already commercially available and are used to fight malaria and tumor growth, respectively. Although the interest in STLs was low for a time after their discovery due to their toxic nature, past decades have witnessed a soar in STL-based studies focused on developing novel pharmaceuticals via chemical diversification. These studies have reported several promising physiological effects for STLs, including lower toxicity and diverse modes of action, and have demonstrated the antimicrobial, antioxidant, hepatoprotective, antiviral, antiprotozoal, phytotoxic, antitumor, and antiaging properties of STLs. STLs are mainly considered as valuable natural molecules for the fight against cancer since most STLs induce death of different types of cancer cells, as shown by in vitro and in vivo studies. Some STLs can also enhance the effects of drugs that are already in clinical use. Medicinal chemists use various STLs as starting molecules for the synthesis of new STLs or different bioactive compounds. All these developments warrant future research to provide more information on STLs, their bioactivities, and their mode of action. In this context, this review has summarized the bioactivities of some of the widely studied STLs, namely artemisinin, costunolide, thapsigargin, arglabin, parthenolide, alantolactone, cynaropicrin, helenalin, and santonin.
Keywords
Anti-cancer; artemisinin; Artemisia spp.; Asteraceae; sesquiterpene lactone;
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