Browse > Article
http://dx.doi.org/10.5352/JLS.2021.31.3.298

Anti-aging and Anti-inflammatory Activities of the Extracts of Calamagrostis arundinacea  

Jeong, Hea Seok (Division of Wild Plant Industrialization Research, Baekdudaegan National Arboretum)
Lee, Dong Ho (Division of Wild Plant Industrialization Research, Baekdudaegan National Arboretum)
Lee, Min-Sung (Division of Wild Plant Industrialization Research, Baekdudaegan National Arboretum)
Heo, Tae Im (Division of Forest Bioresource Conservation, Baekdudaegan National Arboretum)
Kim, Dong Kap (Division of Forest Biodiversity, Korea National Arboretum)
Oh, Seung Hwan (Division of Forest Biodiversity, Korea National Arboretum)
Kim, Du Hyeon (Division of Wild Plant Industrialization Research, Baekdudaegan National Arboretum)
Kim, Yeong-Su (Division of Wild Plant Industrialization Research, Baekdudaegan National Arboretum)
Kim, Dae Wook (Division of Wild Plant Industrialization Research, Baekdudaegan National Arboretum)
Publication Information
Journal of Life Science / v.31, no.3, 2021 , pp. 298-304 More about this Journal
Abstract
The anti-aging and anti-inflammatory activities of hot-water (Ca-HW) and 70% ethanol (Ca-E70) whole-plant Calamagrostis arundinacea extracts, as well as their bioactive potentials, were investigated using cell-free and cell-mediated experimental systems. Use of the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical decolorization assay to evaluate the antioxidant activity of the Ca-HW and Ca-E70 extracts revealed DPPH radical scavenging activities of 27% and 48%, respectively. Neither extract caused significant cytotoxicity, and both showed cell proliferation and promotion effects using RAW 264.7, B16F10, and CCD986sk cells. B16F10 melanoma cells showed higher melanin synthesis when treated with 100 mg/ml Ca-HW or Ca-E70 than with arbutin, indicating a stronger inhibitory effect of arbutin on melanin synthesis. Ca-HW and Ca-E70 increased pro-collagen biosynthesis in the human fibroblast CCD986-SK cell line by 24.69% and 12.55%, respectively. Analysis of the anti-inflammatory effects of different concentrations of Ca-HW and Ca-E70 in RAW264.7 cells revealed that Ca-E70 appeared to inhibit the lipopolysaccharide-induced production of nitric oxide and IL-6, a proinflammatory cytokine; therefore, Ca-E70 showed an anti-inflammatory effect. These results suggested that C. arundinacea extracts could have skin anti-aging and anti-inflammatory properties.
Keywords
Anti-inflammatory; Calamagrostis arundinacea; DPPH; melanin; pro-collagen;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 DuBois, R. N., Tsujii, M., Bishop, P., Awad, J. A., Makita, K. and Lanahan, A. 1994. Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am. J. Physiol. 266, 822-827.
2 Du, C., Bhatia, M., Tang, S. C., Zhang, M. and Steiner, T. 2015. Mediators of inflammation: inflammation in cancer, chronic diseases, and wound healing. Mediators Inflamm. 2015, 570653-570654.
3 Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S. and Voorhees, J. J. 2002. Mechanisms of photoaging and chronological skin aging. Arch. Dermatol. 138, 1462-1470.
4 Fisher, G. J., Quan, T., Purohit, T., Shao, Y., Cho, M. K., He, T., Varani, J., Kang, S. and Voorhees, J. J. 2009. Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Am. J. Pathol. 174, 101-114.   DOI
5 Herrling, T., Jung, K. and Fuchs, J. 2008. The role of melanin as protector against free radicals in skin and its role as free radical indicator in hair. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 69, 1429-1435.   DOI
6 Hoogduijn, M. J., Cemeli, E., Ross, K., Anderson, D., Thody, A. J. and Wood, J. M. 2004. Melanin protects melanocytes and keratinocytes against H2O2-induced DNA strand breaks through its ability to bind Ca2+. Exp. Cell Res. 10, 60-67.
7 Joshi, P. G., Nair, N., Begum, G., Joshi, N. B., Sinkar, V. P. and Vora, S. 2007. Melanocyte-keratinocyte interaction induces calcium signalling and melanin transfer to keratinocytes. Pigment Cell Res. 20, 380-384.   DOI
8 Kim, H. J. and Yun, C. W. 2009. Vascular plants of Mt. Munsu and Mt. Okseok. Kor. J. Environ. Biol. 27, 164-175.
9 Laskin, D. L. and Pendino, K. J. 1995. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. 35, 655-677.   DOI
10 Park, G. H., Park, J. H., Eo, H. J., Song, H. M., Lee, M. H., Lee, J. R. and Jeong, J. B. 2014. Anti-inflammatory effect of the extracts from Abeliophyllum distichum Nakai in LPS-stimulated RAW264.7 cells. Kor. J. Plant Res. 27, 209-214.   DOI
11 Park, S. B., Park, G. H., Kim, H. N., Son, H. J., Song, H. M., Kim, H. S., Jeong, H. J. and Jeong, J. B. 2018. Anti-inflammatory effect of the extracts from the branch of Taxillus yadoriki being parasitic in Neolitsea sericea in LPS-stimulated RAW264.7 cells. Biomed. Pharmacother. 104, 1-7.   DOI
12 Raison, L. C., Capuron, L. and Miller, A. H. 2006. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 27, 24-31.   DOI
13 Sugimoto, K., Nishimura, T., Nomura, K., Sugimoto, K. and Kuriki, T. 2004. Inhibitory effects of α-Arbutin on melanin synthesis in cultured human melanoma cells and a three-dimensional human skin model. Biol. Pharm. Bull. 27, 510-514.   DOI
14 Tipoe, G. L., Leung, T. M., Hung, M. W. and Fung, M. L. 2007. Green Tea polyphenols as an anti-oxidant and antiinflammatory agent for cardiovascular protection. Cardio- vasc. Haematol. Disord. Drug Targets 7, 135-144.   DOI
15 Lee, E. S., Kim, H. J., Yu, J. M., Cho, Y. H., Kim, D. I., Shin, Y. Y., Cho, Y. J., Kwon, O. J. and An, B. J. 2014. Anti-inflammatory effect of Polygonum multiflorum extraction in activated RAW 264.7 cells with lipopolysaccharide. Kor. J. Food Preserv. 21, 740-746.   DOI
16 Willemse, B. W. M., Postma, D. S., Timens, W. and Hacken, N. H. T. 2004. The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation. Eur. Respir. J. 23, 464-476.   DOI
17 Wu, G. and Morris, S. M. 1998. Arginine metabolism: nitric oxide and beyond. Biochem. J. 336, 1-17.   DOI
18 Battino, M., Bullon, P., Wilson, M. and Newman, H. 1999. Oxidative injury and inflammatory periodontal diseases: The challenge of anti-oxidants to free radicals and reactive oxygen species. Crit. Rev. Oral Biol. Med. 10, 458-476.   DOI
19 Chan, Y., Chan, Y. Y., Kim, K. H. and Cheah, S. H. 2011. Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells. J. Ethnopharmacol. 137, 1183-1188.   DOI
20 Cho, B. O., Ryu, H. W., So, Y., Lee, C. W., Jin, C. H., Yook, H. S., Jeong, Y. W., Park, J. C. and Jeong, I. Y. 2014. Anti-inflammatory effect of mangostenone F in lipopolysaccharide-stimulated RAW264.7 macrophages by suppressing NF-kappaB and MAPK activation. Biomol. Ther. 22, 288-294.   DOI
21 Lim, Y. J., Lee, E. H., Kang, T. H., Ha, K. S., Oh, M. S., Kim, S. M., Yoon, T. J., Kang, C., Park, J. H. and Kim, S. Y. 2009. Inhibitory effects of arbutin on melanin biosynthesis of α-melanocyte stimulating hormone-induced hyperpigmentation in cultured brownish Guinea pig skin tissues. Arch. Pharm. Res. 32, 367-373.   DOI
22 Mauviel, A., Halcin, C., Vasiloudes, P., Parks, W. C., Kurkinen, M. and Uitto, J. 1994. Uncoordinate regulation of collagenase, stromelysin, and tissue inhibitor of metalloproteinases genes by prostagladin E2:Selective enhancement of collagenase gene expression in human dermal fibroblasts in culture. J. Cell Biochem. 54, 465-472.   DOI
23 MeDaniel, M. L., Kwon, G., Hill, J. R., Marshall, C. A. and Corbett, J. A. 1996. Cytokines and nitric oxide in islet inflammation and diabetes. Proc. Soc. Exp. Biol. Med. 211, 24-32.   DOI
24 Nam, B. M., Jeong, S., Kim, J. Y., Oh, B. U. and Chung, G. Y. 2016. A flora of vascular plants of Mt. Janggunbong (Bonghwa-gun). Kor. J. Plant Res. 29, 467-478.   DOI
25 Namkoong, S., Jang, S. A., Sohn, E. H., Bak, J. P., Sohn, E., Koo, H. J., Yoon, W. J., Kwon, J. E., Jeong, Y. J., Meng, X., Han, H. S. and Kang, S. C. 2015. Comparative study of Litsea japonica leaf and fruit extract on the anti-inflammatory effects. Kor. J. Plant Res. 28, 145-152.   DOI
26 Parfitt, A. M., Simon, L. S., Villanueva, A. R. and Krane, S. M. 1987. Procollagen type I carboxy-terminal extension peptide in serum as a marker of collagen biosynthesis in bone. Correlation with iliac bone formation Rates and comparison with total alkaline phosphatase. J. Bone Miner. Res. 2, 427-436.   DOI