Comparison of the Cytoprotective Effects of Several Natural and Synthetic Compounds against Oxidative Stress in Human Retinal Pigment Epithelial Cells
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Kim, Da Hye
(Department of Smart Bio-Health, Dong-eui University)
Kim, Jeong-Hwan (Research and Development Department, BGN CARE Co., Ltd.) Park, Seh-Kwang (Research and Development Department, BGN CARE Co., Ltd.) Jeong, Ji-Won (BGN Eye Clinic) Kim, Mi-Young (Research and Development Department, BGN CARE Co., Ltd.) Nam, Soo-Wan (Department of Biotechnology, Dong-eui University) Lee, Hyesook (Anti-Aging Research Center, Dong-eui University) Choi, Yung Hyun (Anti-Aging Research Center, Dong-eui University) |
1 | Zhao, H., Wang, R., Ye, M. and Zhang, L. 2019. Genipin protects against H2O2-induced oxidative damage in retinal pigment epithelial cells by promoting Nrf2 signaling. Int. J. Mol. Med. 43, 936-944. |
2 | Zhou, F. 2018. The potentials of natural compounds in treating human retinal diseases. J. Blood Disord. Transfus. 9, 22. DOI |
3 | Baritaud, M., Cabon, L., Delavallee, L., Galan-Malo, P., Gilles, M. E., Brunelle-Navas, M. N. and Susin, S. A. 2012. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell Death Dis. 3, e390. DOI |
4 | Barot, M., Gokulgandhi, M. R. and Mitra, A. K. 2011. Mitochondrial dysfunction in retinal diseases. Curr. Eye Res. 36, 1069-1077. DOI |
5 | Cai, J., Wu, M., Nelson, K. C., Sternberg Jr, P. and Jones, D. P. 1999. Oxidant-induced apoptosis in cultured human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 40, 959-966. |
6 | Hao, Y., Liu, J., Wang, Z., Yu, L. L. and Wang, J. 2019. Piceatannol protects human retinal pigment epithelial cells against hydrogen peroxide induced oxidative stress and apoptosis through modulating PI3K/Akt signaling pathway. Nutrients 11, E1515. |
7 | Droge, W. 2020. Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95. DOI |
8 | Du, W., An, Y., He, X., Zhang, D. and He, W. 2018. Protection of kaempferol on oxidative stress-induced retinal pigment epithelial cell damage. Oxid. Med. Cell Longev. 2018, 1610751. DOI |
9 | Han, D., Wu, X., Liu, L., Shu, W. and Huang, Z. 2018. Sodium tanshinone IIA sulfonate protects ARPE-19 cells against oxidative stress by inhibiting autophagy and apoptosis. Sci. Rep. 8, 15137. DOI |
10 | He, C. and Klionsky, D. J. 2009. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 43, 67-93. DOI |
11 | Head, K. A. 1999. Natural therapies for ocular disorders, part one: diseases of the retina. Altern. Med. Rev. 4, 342-359. |
12 | Jakubczyk, K., Dec, K., Kaldunska, J., Kawczuga, D., Kochman, J. and Janda, K. 2020. Reactive oxygen species-sources, functions, oxidative damage. Pol. Merkur. Lekarski. 48, 124-127. |
13 | Ji, H. F., Li, X. J. and Zhang, H. Y. 2009. Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep. 10, 194-200. DOI |
14 | Liang, F. Q. and Godley, B. F. 2003. Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp. Eye Res. 76, 397-403. DOI |
15 | Kaarniranta, K., Pawlowska, E., Szczepanska, J., Jablkowska, A. and Blasiak, J. 2019. Role of mitochondrial DNA damage in ROS-mediated pathogenesis of age-related macular degeneration (AMD). Int. J. Mol. Sci. 20, 2374. DOI |
16 | Kim, W. T. and Suh, E. S. 2010. Retinal protective effects of resveratrol via modulation of nitric oxide synthase on oxygen-induced retinopathy. Kor. J. Ophthalmol. 24, 108-118. DOI |
17 | Lai, T. T., Yang, C. M. and Yang, C. H. 2020. Astaxanthin protects retinal photoreceptor cells against high glucose-induced oxidative stress by induction of antioxidant enzymes via the PI3K/Akt/Nrf2 Pathway. Antioxidants (Basel) 9, E729. |
18 | Lakkaraju, A., Umapathy, A., Tan, L. X., Daniele, L., Philp, N. J., Boesze-Battaglia, K. and Williams, D. S. 2020. The cell biology of the retinal pigment epithelium. Prog. Retin. Eye Res. 2020, 100846. |
19 | Li, S., Gaur, U., Chong, C. M., Lin, S., Fang, J., Zeng, Z., Wang, H. and Zheng, W. 2018. Berberine protects human retinal pigment epithelial cells from hydrogen peroxide-induced oxidative damage through activation of AMPK. Int. J. Mol. Sci. 19, 1736. DOI |
20 | Liu, Y., Ren, Y., Wang, X., Liu, X., Xu, Y. and He, Y. 2019. Down regulation of UCP2 expression in retinal pigment epithelium cells under oxidative stress: an in vitro study. Int. J. Ophthalmol. 12, 1089-1094. |
21 | Nishimura, Y., Hara, H., Kondo, M., Hong, S. and Matsugi, T. 2017. Oxidative stress in retinal diseases. Oxid. Med. Cell Longev. 2017, 4076518. |
22 | Mah, L., El-Osta, A. and Karagiannis, T. 2010. γH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 24, 679-686. DOI |
23 | Musat, O., Ochinciuc, U., Gutu, T., Cristescu, T. and Coman, C. 2012. Pathophysiology and treatment of ARMD. Oftalmologia 56, 45-50. |
24 | Newman, D. J., Cragg, G. M. and Snader, K. M. 2003. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod. 66, 1022-1037. DOI |
25 | Sulaiman, R. S., Basavarajappa, H. D. and Corson, T. W. 2014. Natural product inhibitors of ocular angiogenesis. Exp. Eye Res. 129, 161-171. DOI |
26 | Park, C., Lee, H., Hong, S. H., Kim, J. H., Park, S. K., Jeong, J. W., Kim, G. Y., Hyun, J. W., Yun, S. J., Kim, B. W., Kim, W. J. and Choi, Y. H. 2019. Protective effect of diphlorethohydroxycarmalol against oxidative stress-induced DNA damage and apoptosis in retinal pigment epithelial cells. Cutan. Ocul. Toxicol. 38, 298-308. DOI |
27 | Plafker, S. M., O'Mealey, G. B. and Szweda, L. I. 2012. Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int. Rev. Cell. Mol. Biol. 298, 135-177. DOI |
28 | Ruan, Y., Jiang, S., Musayeva, A. and Gericke, A. 2020. Oxidative stress and vascular dysfunction in the retina: Therapeutic strategies. Antioxidants (Basel) 9, E761. |
29 | Salvioli, S., Ardizzoni, A., Franceschi, C. and Cossarizza, A. 1997. JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis. FEBS Lett. 411, 77-82. DOI |
30 | Schmidt, B. M., Ribnicky, D. M., Lipsky, P. E. and Raskin, I. 2007. Revisiting the ancient concept of botanical therapeutics. Nat. Chem. Biol. 3, 360-366. DOI |
31 | Tram, N. K., McLean, R. M. and Swindle-Reilly, K. E. 2020. Glutathione improves the antioxidant activity of vitamin C in human lens and retinal epithelial cells: Implications for vitreous substitutes. Curr. Eye Res. 2020, 1-12. |
32 | Upadhyay, M., Milliner, C., Bell, B. A. and Bonilha, V. L. 2020. Oxidative stress in the retina and retinal pigment epithelium (RPE): Role of aging, and DJ-1. Redox Biol. 2020, 101623. |
33 | Vinores, S. A., Derevjanik, N. L., Ozaki, H., Okamoto, N. and Campochiaro, P. A. 1999. Cellular mechanisms of blood-retinal barrier dysfunction in macular edema. Doc. Ophthalmol. 97, 217-228. DOI |
34 | Yu, M., Anderson, R. E. and Mandal, N. A. 2012. Natural compounds in retinal diseases. In: Stratton R., Hauswirth W. and Gardner, T. (eds) Studies on retinal and choroidal disorders. oxidative stress in applied basic research and clinical practice. Humana Press. 437-456. |
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