1 |
Kim, K. M., Kim, M. J. and Kang, J. S. 2009. Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate. J. Microbiol. Biotechnol. 19, 1569-1572.
DOI
|
2 |
Kim, K. M., Kim, T. H., Park, Y. J., Kim, I. H. and Kang, J. S. 2009. Evaluation of the genotoxicity of decursin and decursinol angelate produced by Angelica gigas Nakai. Mol. Cell. Toxicol. 5, 83-87.
|
3 |
Yang, Y., Yang, K., Li, Y., Li, X., Sun, Q., Meng, H., Zeng, Y., Hu, Y. and Zhang, Y. 2013. Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2. Mol. Cell. Endocrinol. 378, 46-52.
DOI
|
4 |
Kang, J. S., Lee J. Y., Park Y. J., Park, J. Y., Kim, K. M., Park, M. H., Kim, I. H., Hong, Y. G., Jung, M. S., Chung, W. S. and Ok, S. 2007. The composition for anti-gout including the extract of Angelica gigas Nakai that has effects of xanthine oxidase inhibition and COX-2 inhibition, Korea patent 10-2010-0073818.
|
5 |
Moon, C. K., Lee, S. C., Yun, Y. P., Ha, B. J. and Yook, C. S. 1988. Effect of some coumarin derivatives on the bovine lens aldose reductase activity. Arch. Pharm. Res. 11, 308-311.
DOI
|
6 |
Regulations on product approval, notification, and examination of drugs. Ministry of Food and Drug Safety Notice. No. 2017-71, (20147).
|
7 |
Son, C. Y., Baek, I. H., Song, G. Y., Kang, J. S. and Kwon, K. I. 2009. Pharmacological effect of decursin and decursinol angelate from Angelica gigas Nakai. Yakhak Hoeji 53, 303-313.
|
8 |
Son, S. H., Kim, M. J., Chung, W. Y., Son, J. A., Kim, Y. S., Kim, Y. C., Kang, S. S., Lee, S. K. and Park, K. K. 2009. Decursin and decursinol inhibit VEGF-induced angiogenesis by blocking the activation of extracellular signal-regulated kinase and c-Jun N terminal kinase. Cancer Lett. 280, 86-92.
DOI
|
9 |
Kang, J. S., Hwang, S. W., Lee, J. Y., Kim, K. M., Hong, Y. G., Choi, K. J. and Lee, S. K. 2010. The extracts of Angelica gigas Nakai and Angelica gigas Jiri that have decursin and decursinol angelate as active ingredients that affect the improvement of lipid metabolism and the extracting method thereof. Korea patent 2010-10-0995891.
|
10 |
Kang, J. S., Ji, Y. H., Ok, S., Pyo, J. S., Hwang, S. W., Samila, S. A., Kim, B. S., Kim, D. H. and Lee, S. H. 2016. Pharmaceutical composition for treating leukopenia decrease caused by administrating anticancer agent. Korea Patent 10-2016-0111354.
|
11 |
Kang, J. S., Seo, J. L., Lee, J. H. and Kim, I. H. 2019. Making Method of Oral Administration Compositioin for Increasing Sexual Potency. Korea patent 10-2019-0069663.
|
12 |
Kang, S. Y., Lee, K. Y., Park, M. J., Kim, Y. C., Markelonis, G. J., Oh, T. H. and Kim, Y. C. 2003. Decursin from Angelica gigas mitigates amnesia induced by scopolamine in mice. Neurobiol. Learn. Mem. 79, 11-18.
DOI
|
13 |
Kang, S. Y., Lee, K. Y., Sung, S. H., Park, M. J. and Kim, Y. C. 2001. Coumarins isolated from Angelica gigas inhibit acetylcholineterase: Structure-activity relationships. J. Nat. Prod. 64, 683-685.
DOI
|
14 |
Yan, B. C., Park, J. H., Shin, B. N., Ahn, J. H., Kim, I. H., Lee, J. C., Yoo, K. Y., Hwang, I. K., Choi, J. H., Park, J. H., Lee, Y. L., Suh, H. W., Jun, J. G., Kwon, Y. G., Kim, Y. M., Kwon, S. H., Song, H., Kim, J. S., Hyun, B. H., Kim, C. K., Cho, J. C., Lee, C. H. and Won, M. H. 2013. Neuroprotective effect of a new synthetic aspirin-decursinol adduct in experimental animal models of ischemic stroke. PLoS One 8, e74886. 1-12.
DOI
|
15 |
Sung, S. H. and Park, J. H. 2007. Current status and prospects of natural medicinal products. (14-23). Health Venture Latest and Issue report 14
|
16 |
Teppe, D., Ip, R. J. and Ip, J. H. 2000. The use of antiplatelet agents in cardiac disease. Manag. Care Interface 13, 76-78.
|
17 |
Vazquez-Mellado, J., Morales, E. M., Pacheco-Tena, C. and Vargas, R. B. 2001. Relation between adverse events associated with allopurinol and renal function in patients with gout. Ann. Rheum. Dis. 60, 981-983.
DOI
|
18 |
Yim, D. S., Singh, R. P., Agarwal, C., Lee, S. K., Chi, H. J. and Agarwal, R. 2005. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. 65, 1035-1044.
DOI
|
19 |
Jeon, Y. J., Shin, J. I., Lee, S., Lee, Y. G., Kim, J. B., Kwon, H. C., Kim, S. H., Kim, I. K., Lee, K. H. and Han, Y. S. 2018. Angelica gigas Nakai has synergetic effects on doxorubicin- induced apoptosis. Biomed. Res. Int. Article ID 6716547. 11 pages.
|
20 |
Lee, S., Lee, Y. S., Jung, S. H., Shin, K. H., Kim, B. K. and Kang, S. S. 2003. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch. Pharm. Res. 26, 727-730.
DOI
|
21 |
Park, K W., Choi, S. R., Yang, H. S., Cho, H. W., Kang, K. S. and Seo, K. I. 2007. Anti-proliferation effects of decursin from Angelica gigas Nakai in the MCF-7 cells treated with environmental hormones. J. Kor. Soc. Food Sci. Nutr. 36, 825-831.
DOI
|
22 |
Adams, J. D., Flora, K. P., Goldspiel, B. R., Wilson, J. W., Arbuck, S. G. and Finley, R. 1993. Taxol: a history of pharmaceutical development and current pharmaceutical concerns. J. Natl. Cancer Inst. Monogr. 15, 141-147.
|
23 |
Lee, Y. Y., Lee, S., Jin, J. L. and Yun-Choi, H. S. 2003. Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Arch. Pharm. Res. 26, 723-726.
DOI
|
24 |
Li, C., Li, J., Fan, J., Meng, L. and Cao, L. 2017. Decursin reduces reactive oxygen species and inhibits cisplatin-induced apoptosis in rat renal tubular epithelial cells. Chinese Journal of Cellular and Molecular Immunology 33, 1328-1334.
|
25 |
Libby, P., Ridker, P. M. and Maseri, A. 2002. Inflammation and atherosclerosis. Circulation 105, 1135-1143.
DOI
|
26 |
Lim, V., Schneider, E., Wu, H. and Pang, I. 2018. Cataract preventive role of isolated phytoconstituents: Findings from a decade of research. Nutrients 10, 1580-1619.
DOI
|
27 |
Ohshiro, T., Namatame, I., Lee, E. W., Kawagishi, H. and Tomoda, H. 2006. Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages. Biol. Pharm. Bull. 29, 981-984.
DOI
|
28 |
Ok, S., Lee, J. H., Kim, I. H. and Kang, J. S. 2011. Glucose transporters and AMP-activated protein kinase modulation effects of decursin and decursinol angelate on diabetic rats. YakHak Hoeji 55, 301-308.
|
29 |
Park, K. W., Choi, S. R., Hong, H. R., Kim, J. Y., Shon, M. Y. and Seo, K. I. 2007. Biological activities of methanol extract of Angelica gigas Nakai. Kor. J. Food Preserv. 14, 655-661.
|
30 |
Ahn, K. S., Sim, W. S. and Kim, I. H. 1995. Decursin: A cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. 62, 7-9.
DOI
|
31 |
Bae, E. A., Han, M. J., Kim, N. J. and Kim, D. H. 1998. Anti-Helicobacter pylori activity of herbal medicines. Biol. Pharm. Bull. 21, 990-992.
DOI
|
32 |
Chakraborti, S., Mandal, M., Das, S., Mandal, A. and Chakraborti, T. 2003. Regulation of matrix metalloproteinases: an overview. Mol. Cell. Biochem. 253, 269-285.
DOI
|
33 |
Chang, S. N., Khan, I., Kim, C. G., Park, S. M., Choi, D. K., Lee, H. J., Hwang, B. S., Kang, S. C. and Park, J. G. 2021. Decursinol angelate arrest melanoma cell proliferation by initiating cell death and tumor shrinkage via induction of apoptosis Int. J. Mol. Sci. 22, 4096-4115.
DOI
|
34 |
Humpel, C. 2017. Platelets: their potential contribution to the generatiom of beta-amyloid plaques in Alzheimer's disease. Curr. Neurovasc. Res. 14, 290-298.
DOI
|
35 |
Cushman, D. W. and Ondetti, M. A. 1991. History of design of captopril and related inhibitors of angiotensin converting enzyme. Hypertension 17, 589-592.
DOI
|
36 |
Davies, P. and Maloney, A. J. 1976. Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 308, 1403.
DOI
|
37 |
Fritsma, G., Engelmann, G. and Yousuf, M. 1981. A review of platelet function and testing. Am. J. Med. Technol. 47, 723-727.
|
38 |
Herbal Medicine School Revision Committee. 2006. Herbal Pharmacy 5th Edition, Dongmyeongsa, Seoul.
|
39 |
http://www. Druginfo.co.kr.
|
40 |
Kim, K. M., Ok, S., Go, Y. S. and Kang, J. S. 2015. Recovery from the two-generation reproductive toxicity in sprague-dawley rats by treatment with decursin and decursinol angelate. J. Life Sci. 25, 765-772.
DOI
|
41 |
Hwang, B. M., Noh, E. M., Kim, J. S., Kim, J. M., Hwang, J. K., Kim, H. K., Kang, J. S., Kim, D. S., Chae, H. J., You, Y. O., Kwon, K. B. and Lee, Y. R. 2013. Decursin inhibits UVB-induced MMP expression in human dermal fibroblasts via regulation of nuclear factor-κB. Int. J. Mol. Med. 31, 477-483
DOI
|
42 |
Park, K. W., Choi, S. R., Shon, M. Y., Jeong, I. Y., Kang, K. S., Lee, S. T., Shim, K. H. and Seo, K. I. 2007. Cytotoxic effects of decursin from Angelica gigas Nakai in human cancer cells. J. Kor. Soc. Food Sci. Nutr. 36, 1385-1390.
DOI
|
43 |
Qiu, T., Liu, Q., Chen, Y. X., Zhao, Y. F. and Li, Y. M. 2015. Aβ42 and Aβ40: similarities and differences. J. Pept. Sci. 21, 522-529.
DOI
|
44 |
Ryu, J. H., Ahn, H., Kim, J. Y. and Kim, Y. K. 2003. Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages. Phytother. Res. 17, 485-489.
DOI
|
45 |
http://www.chemicalregister.com/Decursin/Suppliers/pid46920.htm.
|
46 |
https://pubmed.ncbi.nlm.nih.gov/?term=ANGELICA%20GIGAS&filter
|
47 |
Jedziniak, J. A. and Kinoshita, J. H. 1971. Activators and inhibitors of lens aldose reductase. Invest. Ophthalmol. 10, 357-366.
|
48 |
Dschang, J., Jung, D. J., Porzel, A. and Huneck, S. 1991. Gigasol and other coumarins from Angelica gigas. Phytochemistry 30, 710-712.
DOI
|
49 |
Jung, M. H., Lee, S. H., Ahn, E. M. and Lee, Y. M. 2009. Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway. Carcinogenesis 30, 655-661.
DOI
|
50 |
Kang, J. S., Choung, C. K., Chang, N. Y., Lee, J. Y., Pyo, J. S., Kim, C. M., Kim, H. S., Kim, H. H., Kwon, C. N. and Kim, S. H. 2020. Composition comprising compound K and decursinol for extending life span and stimulating differentiation of cells. Korea patent 10-2018-0120909.
|
51 |
Kang, J. S., Chung, Y. S., Lee, J. Y., Kim, H. S., Kang, H. A. and Choi, M. S. 2018. Composition for preventing or treating of thrombocytopenia or lymphopenia comprising decursinol. Korea Patent 10-2009-0020875.
|
52 |
Kim, K. M., Kim, B. S. and Kang, J. S. 2018. The preventive effect of Bacillus polyfermenticus KJS-2 and Angelica gigas Nakai extract on triton WR-1339-induced hyperlipidemia. J. life Sci. 28, 726-732.
DOI
|
53 |
Kim, H. H., Ahn, K. S., Han, H. G., Choung, S. Y., Choi, S. Y. and Kim, I. H. 2005. Decursin and PDBu: two PKC activators distinctively acting in the megakaryocytic differentiation of K562 human erythroleukemia cells. Leuk. Res. 29, 1407-1413.
DOI
|
54 |
Jeffers, M. G. 2007. Composition and methods for the treatment of joint pain using Angelica gigas Nakai extract and powder as combined with glucosamine sulfate, or chondroitin sulfate and HCl, of MSM, of aspirin, or celedrin, and as combinations thereof in powder, pill, capsule, spray, liquid, and gelcap form. U. S Patent Application No. 2007/0264370 A1.
|
55 |
Middleton, E. A., Weyrich, A. S. and Zimmerman, G. A. 2016. Platelets in pulmonary immune responses and inflammatory lung diseases. Physiol. Rev. 96, 1211-1259.
DOI
|
56 |
Mikhail, Y., Inyushin, P. S., Legier, R., Yuriy, K. and Lilia, K. 2017. Aβ peptide originated from platelets promises new strategy in anti-alzheimer's drug development. Bio Med Research International, Article ID 3948360, 1-10.
|
57 |
Jeong, S. Y., Kim, I. H., Ahn, K. S. and Kim, S. K. 1999. Pharmaceutical composition containing decursin. PCT/KR 1999/00632.
|
58 |
Ahn, M. J., Lee, M. K., Kim, Y. C. and Sung, S. H. 2008. The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography diode array detector coupled with electroionization/mass spectrophotometry. J. Pharm. Biomed. 46, 258-266.
DOI
|
59 |
Kang, J. S., Kim, H. H., Pyo, J. S., Lee, S. J., Hwang, Y. J., Kim, H. S. and Choi, J. G. 2021. Composition for preventing or treating of disease caused by hyper-proliferation of vascular smooth muscle cell comprising decursinol as active ingredient. 2021. Korea Patent 10-2021-0004607.
|
60 |
Kang, S. Y. and Kim, Y. C. 2007. Neuroprotective coumarins from the root of Angelica gigas: structure-activity relationships. Arch. Pharm. Res. 30, 1368-1373.
DOI
|
61 |
Kim, K. M., Jeong, J. Y., Hwang, S. W., Kim, M. J. and Kang, J. S. 2009. Isolation and purification of decursin and decursinol angelate in Angelica gigas Nakai. J. Kor. Soc. Food Sci. Nutr. 38, 653-656.
DOI
|
62 |
Zhang, L., Fiala, M., Cashman, J., Sayre, J., Espinosa, A., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G. and Rosenthal, M. 2006. Curcuminoids enhance amyloid-β uptake by macrophages of Alzheimer's disease patients. J. Alzheimers Dis. 10, 1-7.
DOI
|
63 |
Kim, K. M., Jeong, J. Y., Hwang, S. W., Kim, M. J. and Kang, J. S. 2009. Isolation and purification of decursin and decursinol angelate in Angelica gigas Nakai. J. Kor. Soc. Food Sci. Nutr. 38, 653-656.
DOI
|
64 |
Kim, J. H., Jeong, J. H., Jeon, S. T., Kim, H., Ock, J. Y., Suk, K. H., Kim, S. I., Song, K. S. and Lee, W. H. 2006. Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-κB activation in macrophages. Mol. Pharmacol. 69, 1783-1790.
DOI
|
65 |
Kim, K. M., Lee, J. Y., Hong, Y. G. and Kang, J. S. 2009. Oral acute and subacute toxicity studies of decursin and decursinol angelate of Angelica gigas Nakai. Mol. Cell. Toxicol. 5, 153-159.
|
66 |
Kim, K. M., Seo, J. L. and Kang, J. S. 2014. Decursin and decursinol angelate affect spermatogenesis in the adult rat at oral administration. Mol. Cell. Toxicol. 10, 83-89.
DOI
|
67 |
Kim, S. M., Yoon, S. H., Jeong, D. K., Han, J. H., Yu, W. Y., Lee, C. J., Kim, H. Y., Kang, S. J., Kim, D. S. and Kim, E. J. 1993. A clinical study on the microvascular complication of diabetes mellitus. J. Kor. Diabetes Assoc. 17, 293-300.
|
68 |
Lee, K. Y., Sung, S. H., Kim, S. H., Jang, Y. P., Oh, T. H. and Kim, Y. C. 2009. Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice. Arch. Pharm. Res. 32, 677-683.
DOI
|
69 |
Lee, S. H., Suh, S. J., Lee, K. H., Yang, J. B., Choi, S. U. and Park, S. S. 2013. Anti-inflammatory effect of peel extracts from citrus fruits. J. Fd Hyg. Safety 28, 342-348.
DOI
|
70 |
Lee, S., Lee, Y. S., Jung, S. H., Shin, K. H. and Kim, B. K. 2003. Antioxidant activities of decursinol angelate and decursin from Angelica gigas roots. Nat. Prod. Sci. 9, 170-173.
|
71 |
Recknagel, R. O., Glende, E. A. Jr., Dolak, J. A. and Waller, R. L. 1989. Mechanisms of carbon tetrachloride toxicity. Pharmac. Ther. 43, 139-154.
DOI
|
72 |
Grana, X. and Reddy, E. P. 1995. Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinase (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211-219.
|
73 |
Chang, W. S. and Chiang, H. C. 1995. Structure-activity relationship of coumarins in xanthine oxidase inhibition. Anticancer Res. 15, 1969-1973.
|
74 |
Kim, J. H., Jeong, S. J., Kwon, H. Y., Park, S. Y., Lee, H. J., Lee, H. J., Lieske, J. C. and Kim, S. H. 2010. Decursin prevents cisplatin-induced apoptosis via the enhancement of antioxidant enzymes in human renal epithelial cells. Biol. Pharm. Bull. 33, 1279-1284.
DOI
|