Ethanol Extract of Hermetia illucens Larvae Inhibits Adipogenesis in 3T3-L1 Adipocytes
![]() |
Park, Ji Yeong
(Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA)
Kwak, Kyu-Won (Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) Choi, Ji-Yeon (Southeast Medi-Chem Institute) Lee, Si-Eun (Southeast Medi-Chem Institute) Kim, Yong-Soon (Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) Koo, Bonwoo (Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) Kim, Eunsun (Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) Park, Kwanho (Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) Kim, Sun Young (Industrial Insect and Sericulture Division, Department of Agricultural Biology, National Institute of Agricultural Sciences, RDA) |
1 | Ali, M. F. Z., Ohta, T., Ido, A., Miura, C. and Miura, T. 2019. The dipterose of black soldier fly (Hermetia illucens) induces innate immune response through Toll-like receptor pathway in mouse macrophage RAW264.7 cells. Biomolecules 9, E677. |
2 | Rodgers, R. J., Tschop, M. H. and Wilding, J. P. 2012. Antiobesity drugs: Past, present and future. Dis. Models Mech. 5, 621-626. DOI |
3 | Chung, M. Y., Yoon, Y. I., Hwang, J. S., Goo, T. W. and Yun, E. Y. 2014. Anti-obesity effect of Allomyrina dichotoma (Arthropoda: Insecta) larvae ethanol extract on 3T3-L1 adipocyte differentiation. Entomol. Res. 44, 9-16. DOI |
4 | Gujarathi, G. and Pejaver, M. 2013. Occurrence of black soldier fly Hermetia illucens (Diptera: Stratiomyidae) in biocompost. Res. J. Recent Sci. 2, 65-66. |
5 | Flegal, K. M., Graubard, B. I., Williamson, D. F. and Gail, M. H. 2007. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 298, 2028-2037. DOI |
6 | Alvarez, D., Wikinson, K. A., Treihou, M., Tene, N., Castillo, D. and Sauvain, M. 2019. Prospecting peptides isolated from black soldier fly (Diptera: stratiomyidae) with antimicrobial activity against Helicobacter pylori (Campylobacterales: Helicobacteraceae). J. Insect Sci. 19, 1-5. |
7 | Bradford, B. L. and Bruce, M. S. 2000. Towards a molecular understanding of adaptive thermogenesis. Nature 404, 652-660. DOI |
8 | Firmansyah, M. and Abduh, M. Y. 2019. Production of protein hydrolysate containing antioxidant activity from Hermetia illucens. Heliyon 5, e02005. DOI |
9 | Gupta, R., Rathi, P., Gupta, N. and Bradoo, S. 2003. Lipase assays for conventional and molecular screening: an overview. Biotechnol. Appl. Biochem. 37, 63-71. DOI |
10 | Guzman, A. K., Ding, M., Xie, Y. and Martin, K. A. 2014. Pharmacogenetics of obesity drug therapy. Curr. Mol. Med. 14, 891-908. DOI |
11 | Kaur, J. 2014. A comprehensive review on metabolic syndrome. Cardiol. Res. Pract. 2014, 943162. DOI |
12 | Nam, Y. R., Ko, Y. E. and Ly, S. Y. 2018. Anti-obesity and LDL- cholesterol lowering effects of silkworm hemolymph in C57BL/6N mice fed high fat diet. J. Nutr. Health 51, 201-207. DOI |
13 | Gwon, S. Y., Ahn, J. Y., Kim, T. W. and Ha, T. Y. 2012. Zanthoxylum piperitum DC ethanol extract suppresses fat accumulation in adipocytes and high fat diet-induced obese mice by regulating adipogenesis. J. Nut. Sci. Vitaminol. 58, 393-401. DOI |
14 | Kim, D. J., Jung, J. H., Kim, S. G., Lee, H. K., Lee, S. K., Hong, H. D., Lee, B. Y. and Lee, O. H. 2011. Antioxidants and antiobesity activities of hot water and ethanolic extracts from Cheonnyuncho. Kor. J. Food Preserv. 18, 366-373. DOI |
15 | Lee, S. H., Lee, Y. R., Ryu, D. G., Kim, H. R., Kim, M. S., Kim, B. S. and Kwon, K. B. 2016. Inhibitory effects of Albizziae cortex extracts on adipocyte differentiation. J. Physiol. Pathol. Kor. Med. 30, 447-451. DOI |
16 | Rosen, E. D., Walkey, C. J., Puigserver, P. and Spiegelman, B. M. 2002. Transcriptional regulation of adipogenesis. Genes Dev. 14, 1293-1307. |
17 | Kim, W., Bae, S., Kim, A., Park, K., Lee, S., Choi, Y., Han, S., Park, Y. and Koh, Y. 2011. Characterization of the molecular features and expression patterns of two serine proteases in Hermetia illucens (Diptera: Stratiomyidae) larvae. BMB Rep. 44, 387-392. DOI |
18 | Seo, M. C., Goo, T. W., Chung, M. Y., Baek, M. H., Hwang, J. S., Kim, M. A. and Yun, E. Y. 2017. Tenebrio molitor larvae inhibit adipogenesis through AMPK and MAPKs signaling in 3T3-L1 adipocytes and obesity in high-fat diet-induced obese mice. Int. J. Mol. Sci. 18, 518. DOI |
19 | Sim, Y., Kim, D., Pyo, S., Sohn, H., Jung, C., Kim, D. and Cho, Y. 2020. Oils from Tenebrio molitor and Hermetia illucens prevent binge Alcohol-induced gut leakiness and hepatic inflammation. J. Kor. Soc. Food Sci. Nutr. 49, 1175-1183. DOI |
20 | Ji, S. Y., Park, G., Kim, K., Lee, H. S., Choi, G., Kim, Y., Yu, R., Choi, I. and Chung, T. H. 2018. Influence of Hermetia illucens larvae-derived functional feed additives on immune function of broilers. J. Environ. Sci. Int. 27, 1305-1307. DOI |
21 | Yoon, Y. I., Chung, M. Y., Hwang, J. S., Han, M. S., Goo, T. W. and Yun, E. Y. 2015. Allomyrina dichotoma (Arthropoda: Insecta) larvae confer resistance to obesity in mice fed a high-fat diet. Nutrients 7, 1978-1991. DOI |
22 | Park, J. Y. and Kim, J. B. 2002. Molecular insights into fat cell differentiation and functional roles of adipocytokines. Endocrinol. Metab. 17, 1-9. |
23 | Kim, K. B. and Jang, S. H. 2014. Anti-obesity effect of EGCG and glucosamine-6-phosphate through decreased expression of genes related to adipogenesis and cell cycle arrest in 3T3-L1 adipocyte. J. Nutr. Health 47, 1-11. DOI |
24 | Ministry of health and welfare. 2015. Korea Health Promotion Institution. The 4th National Health Promotion Plan (2016-2020). Sejong, Korea. |
25 | Miyanoshita, A., Hara, S., Sugiyama, M., Asaoka, A., Taniai, K., Yukuhiro, F. and Yamakawa, M. 1996. Isolation and characterization of a new member of the insect defensin family from a beetle, Allomyrina dichotoma. Biochem. Biophys. Res. Commun. 220, 526-531. DOI |
26 | Peng, Y., Yu, S., Li, H., Xiang, H., Peng, J. and Jiang, S. 2014. MicroRNAs: Emerging roles in adipogenesis and obesity. Cell Signal. 26, 1888-1896. DOI |
27 | Rayalam, S., Della-Fera, M. A. and Baile, C. A. 2008. Phytochemicals and regulation of the adipocyte life cycle. J. Nutr. Biochem. 19, 717-726. DOI |
28 | Suh, H. J., Kim, S. R., Lee, K. S., Park, S. and Kang, S. C. 2010. Antioxidant activity of various solvent extracts from Allomyrina dichotoma (Arthropoda: Insecta) larvae. J. Photochem. Photobiol. B. Biol. 99, 67-73. DOI |
29 | Prusty, D., Park, B. H., Davis, K. E. and Farmer, S. R. 2002. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma) and C/EBP alpha gene expression during the differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 277, 46226-46232. DOI |
30 | Shon, M. S. and Kim, G. N. 2014. Anti-oxidant and antiobese activities of turmeric (Curcuma longa L.) extract in 3T3-L1 Cells. Kor. J. Aesthet. Cosmetol. 12, 169-175. |
31 | Rowen, E. D. and MacDougald, O. A. 2006. Adipocyte differentiation from the inside out. Nat. Rev. Mol. Cell Biol. 7, 885-896. DOI |
32 | Sagisaka, A., Miyanoshita, A., Ishibashi, J. and Yamakawa, M. 2001. Purification, characterization and gene expression of a glycine and proline-rich antibacterial protein family from larvae of a beetle, Allomyrina dichotoma. Insect Mol. Biol. 10, 293-302. DOI |
33 | Shin, O. S., Shin, Y. H., Lee, K. H., Kim, G. Y., Kim, K. H., Park, J. K., Ahn, J. I. and Song, K. Y. 2012. Inhibition of adipogenesis in 3T3-L1 adipocytes with ethanol extracts of Saururus chinensis. KSBB J. 27, 381-386. DOI |
![]() |