Inhibitory Effect of Protaetiamycine 9 Derived from Protaetia brevitarsis seulensis Larvae on LPS-mediated Inflammation in RAW264.7 Cells
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Choi, Ra-Yeong
(Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration)
Seo, Minchul (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Lee, Joon Ha (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Kim, In-Woo (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Kim, Mi-Ae (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) Hwang, Jae-Sam (Department of Agricultural Biology, National Institute of Agricultural Sciences, Rural Development Administration) |
1 | Choi, I. H., Yu, R., Lim, Y. J., Choi, G. S., Choi, S. U., Hwang, J. I., Son, J. S. and Chung, T. H. 2019. Antithrombotic efficacy of Protaetia brevitarsis extract. J. Environ. Sci. Int. 28, 639-643. DOI |
2 | Hwang, D., Goo, T. W. and Yun, E. Y. 2020. In vitro protective effect of paste and sauce extract made with Protaetia brevitarsis larvae on HepG2 cells damaged by ethanol. Insects 11, 494. DOI |
3 | Kim, M. J., Kim, K. B. W. R., Park, S. H., Park, S. Y., Choi, H. D., Choi, J. S., Jang, M. R., Im, M. H. and Ahn, D. H. 2017. Anti-inflammatory effect of ethanolic extract from Polyopes affinis through suppression of NF-κB and MAPK activation in LPS-stimulated RAW264.7 cells. J. Kor. Soc. Food Sci. Nutr. 46, 537-544. DOI |
4 | Guzik, T. J., Korbut, R. and Adamek Guzik, T. 2003. Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54, 469-487. |
5 | Nathan, C. and Xie, Q. W. 1994. Nitric oxide synthases: roles, tolls, and controls. Cell 78, 915-918. DOI |
6 | Lee, H. S., Ryu, H. J., Song, H. J. and Lee, S. O. 2017. Enzymatic preparation and antioxidant activities of protein hydrolysates from Protaetia brevitarsis larvae. J. Kor. Soc. Food Sci. Nutr. 46, 1164-1170. DOI |
7 | Lee, J. H., Baek, M., Lee, H. J., Kim, I. W., Kim, S. Y., Seo, M., Kim, M. A., Kim, S. H. and Hwang, J. S. 2019. Anti-inflammatory activity of antimicrobial peptide protaetiamycine 2 derived from the Protaetia brevitarsis seulensis. J. Life Sci. 29, 1218-1226. |
8 | Lee, S. H., Lee, E. J., Chung, C., Sohn, H. Y. and Kim, J. S. 2019. Hesperetin ameliorates inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells via p38 MAPK and ERK1/2. J. Life Sci. 29, 129-134. DOI |
9 | Lee, S., Seo, Y. H., Song, J. H., Kim, W. J., Lee, J. H., Moon, B. C., Ang, M. J., Kim, S. H., Moon, C., Lee, J. and Kim, J. S. 2021. Neuroprotective effect of Protaetia brevitarsis seulensis' water extract on trimethyltin-induced seizures and hippocampal neurodegeneration. Int. J. Mol. Sci. 22, 679. DOI |
10 | Li, H., Zhang, Q., Jin, X., Zou, X., Wang, Y., Hao, D., Fu, F., Jiao, W., Zhang, C., Lin, H., Matsuzaki, K. and Zhao, F. 2018. Dysifragilone A inhibits LPS-induced RAW264.7 macrophage activation by blocking the p38 MAPK signaling pathway. Mol. Med. Rep. 17, 674-682. |
11 | Nam, N. H. 2006. Naturally occurring NF-κB inhibitors. Mini Rev. Med. Chem. 6, 945-951. DOI |
12 | Park, J. H. and Lee, S. R. 2018. Anti-inflammatory activities of Scolopendra subspinipes mutilans in RAW264.7 cells. J. Nutr. Health 51, 323-329. DOI |
13 | Seo, J. K. 2016. Screening and purification of an antimicrobial peptide from the gill of the Manila clam Ruditapes philippinarum. Kor. J. Fish Aquat. Sci. 49, 137-145. DOI |
14 | Shin, Y. P., Lee, J. H., Kim, I. W., Seo, M., Kim, M. A., Lee, H. J., Baek, M., Kim, S. H. and Hwang, J. S. 2020. Anti-inflammatory activity of antimicrobial peptide Papiliocin 3 derived from the swallowtail butterfly, Papilio xuthus. J. Life Sci. 30, 886-895. DOI |
15 | Kim, D. G., Shin, J. H. and Kang, M. J. 2018. Antioxidant and anti-inflammatory activities of water extracts and ethanol extracts from Portulaca oleracea L. Kor. J. Food Preserv. 25, 98-106. DOI |
16 | Kang, I. J., Chung, C. K., Kim, S. J., Nam, S. M. and Oh, S. H. 2001. Effects of Protaetia orientalis (Gory et Perchlon) larva on the lipid metabolism in carbon tetrachloride administered rats. Appl. Microsc. 31, 9-18. |
17 | Kawai, T. and Akira, S. 2007. Signaling to NF- κB by toll-like receptors. Trends Mol. Med. 13, 460-469. DOI |
18 | Kim, C. H., Lee, Y. K., Jeong, J. W., Hwang, B. S., Jeong, Y. T., Oh, Y. T., Cho, P. Y. and Kang, C. H. 2021. Anti-inflammatory effects of Hemistepta lyrata Bunge in LPS-stimulated RAW264.7 cells through regulation of MAPK signaling pathway. Kor. J. Plant Res. 34, 23-30. DOI |
19 | Kim, D. H., Kim, H. J., Lee, J. Y., Hwang, J. S., Kim, I. W., Lee, S. G., Jeong, H. G. and An, B. J. 2013. Anti-inflammatory effect of HaGF peptide of Harmonia axyridis. J. Life Sci. 23, 495-500. DOI |
20 | Kim, J. K., Park, S. Y., Choi, H. Y., Jang, M. H., Jung, D. H., Kim, S. C. and Cho, I. J. 2019. Anti-inflammatory effect of Hemistepta lyrata Bunge (Bunge) on LPS-induced inflammation in RAW264.7 cells. Herb. Formula Sci. 27, 7-16. DOI |
21 | Kim, M. S., Jeong, J. S., Lee, H. Y., Ju, Y. S., Bae, G. S., Seo, S. W., Cho, I. J., Park, S. J. and Song, H. J. 2011. The anti-inflammatory effect of Achyranthes japonica on lipopolysaccharide-induced inflammatory activity in murine macrophages. Kor. J. Herbology 26, 51-57. DOI |
22 | Krishnan, M., Choi, J., Jang, A. and Kim, Y. 2020. A novel peptide antibiotic, Pro10-1D, designed from insect defensin shows antibacterial and anti-inflammatory activities in sepsis models. Int. J. Mol. Sci. 21, 6216. DOI |
23 | Lee, H. J., Seo, M., Baek, M., Shin, Y. P., Lee, J. H., Kim, I. W., Hwang, J. S. and Kim, M. A. 2020. Inhibitory effect of Protaetiamycine 6 on neuroinflammation in LPS-stimulated BV-2 microglia. J. Life Sci. 30, 1078-1084. DOI |
24 | Sim, S. Y., Ahn, H. Y. and Cho, Y. S. 2019. Effect of Protaetia brevitarsis seulensis larvae fermented by Bacillus subtilis on serum lipid contents and liver morphology in orotic acid-induced fatty-liver model Sprague-Dawley rats. Kor. J. Food Preserv. 26, 821-827. DOI |
25 | Sung, G. A., Kim, M. H. and Park, S. N. 2016. Anti-inflammatory and whitening effects of Protaetia brevitarsis Seulensis extracts by oriental conversion methods. J. Soc. Cosmet. Sci. Korea 42, 421-432. DOI |
26 | Yi, G., Li, H., Liu, M., Ying, Z., Zhang, J. and Liu, X. 2020. Soybean protein derived peptides inhibit inflammation in LPS induced RAW264.7 macrophages via the suppression of TLR4 mediated MAPK JNK and NF kappa B activation. J. Food Biochem. 44, e13289. |
27 | Yun, H. J., Lee, Y. J., Kang, M. S. and Baek, J. H. 2009. Inhibitory effect of Coicis semen extract (CSE) on pro-inflammatory mediatory. J. Pediatr. Kor. Med. 23, 159-171. |
28 | Zasloff, M. 2002. Antimicrobial peptides of multicellular organisms. Nature 415, 389-395. DOI |
29 | Chon, J. W., Kweon, H. Y., Jo, Y. Y., Yeo, J. H. and Lee, H. S. 2012. Protective effects of extracts of Protaetia brevitarsis on carbon tetrachloride-induced hepatotoxicity in the mice. J. Seric. Entomol. Sci. 50, 93-100. DOI |
30 | Chung, M. Y., Gwon, E. Y., Hwang, J. S., Goo, T. W. and Yun, E. Y. 2013. Analysis of general composition and harmful material of Protaetia brevitarsis. J. Life Sci. 23, 664-668. DOI |
31 | Feldmann, M., Brennan, F. M. and Maini, R. N. 1996. Role of cytokines in rheumatoid arthritis. Annu. Rev. Immunol. 14, 397-440. DOI |
32 | Guha, M. and Mackman, N. 2001. LPS induction of gene expression in human monocytes. Cell. Signal. 13, 85-94. DOI |
33 | Ahn, E. M., Myung, N. Y., Jung, H. A. and Kim, S. J. 2019. The ameliorative effect of Protaetia brevitarsis larvae in HFD-induced obese mice. Food Sci. Biotechnol. 28, 1177-1186. DOI |
34 | Xu, L., Pathak, P. S. and Fukumura, D. 2004. Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells. Clin. Cancer Res. 10, 701-707. DOI |
35 | Lee, J. Y., Choi, J. W., Lee, M. K., Kim, Y. M., Kim, I. H. and Nam, T. J. 2014. Anti-inflammatory effects of Pyropia yezoensis extract in LPS-stimulated RAW264.7 cells. Kor. J. Fish Aquat. Sci. 47, 757-764. DOI |
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