Inhibitory Effect of Scopoletin Isolated from Sorbus commixta on TNF-α-Induced Inflammation in Human Vascular Endothelial EA.hy926 Cells through NF-κB Signaling Pathway Suppression |
Kang, Hye Ryung
(National Institute for Korean Medicine Development)
Kim, Hyo Jung (National Institute for Korean Medicine Development) Kim, Bomi (National Institute for Korean Medicine Development) Kim, Sun-Gun (National Institute for Korean Medicine Development) So, Jai-Hyun (National Institute for Korean Medicine Development) Cho, Soo Jeong (Department of Pharmaceutical Engineering, Gyeongnam National University of Science and Technology) Kwon, Hyun Sook (National Institute for Korean Medicine Development) |
1 | Bosshart, H. and Heinzelmann, M. 2016. THP-1 cells as a model for human monocytes. Ann. Transl. Med. 4, 438. DOI |
2 | Chang, H. C., Yang, H. L., Pan, J. H, Korivi, M., Pan, J. Y., Hsieh, M. C., Chao, P. M., Huang, P. J., Tsai, C. T. and Hseu, Y. C. 2016. Hericium erinaceus inhibits TNF--induced angiogenesis and ROS generation through suppression of MMP-9/NF- signaling and activation of Nrf2-mediated antioxidant genes in human EA.hy926 endothelial cells. Oxid. Med. Cell Longev. 2016, 1-15. |
3 | Cheng, A. S., Cheng, Y. H. and Chang, T. L. 2012. Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4T cells. Food Funct. 3, 886-890. DOI |
4 | Cho, Y. S., Kim, C. H., Ha, T. S., Lee, S. J. and Ahn, H. Y. 2013. Ginsenoside Rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. Kor. J. Physiol. Pharmacol. 17, 133-137. DOI |
5 | De Martin, R., Hoeth, M., Hofer-Warbinek, R. and Schmid, J. A. 2000. The transcription factor NF- and the regulation of vascular cell function. Arterioscler. Thromb. Vasc. Biol. 20, 83-88. DOI |
6 | Della Greca, M., Monaco, P. and Previtera, L. 1990. Stigmasterols from Typha latifolia. J. Nat. Prod. 53, 1430-1435. DOI |
7 | Frostegard, J., Haegerstrand, A., Gidlund, M. and Nilsson, J. 1991. Biologically modified LDL increases the adhesive properties of endothelial cells. Atherosclerosis 90, 119-126. DOI |
8 | Hien, T. T., Kim, N. D., Kim, H. S. and Kang, K. W. 2010. Ginsenoside Rg3 inhibits tumor necrosis factor--induced expression of cell adhesion molecules in human endothelial cells. Pharmazie 65, 699-701. |
9 | Sohn, E. J., Kang, D. G., Choi, D. H., Lee, A. S., Mun, Y. J., Woo, W. H., Kim, J. S. and Lee, H. S. 2005b. Effect of methanol extract of Sorbus cortex in rat model of L-NAMEinduced atherosclerosis. Biol. Pharmaceut. Bull. 28, 1239-1243. DOI |
10 | Sohn, E. J., Kang, D. G., Mun, Y. J., Woo, W. H. and Lee, H. S. 2005a. Anti-atherogenic effects of the methanol extract of Sorbus cortex in atherogenic-diet rats. Biol. Pharmaceut. Bull. 28, 1444-1449. DOI |
11 | Yin, M. H., Kang, D. G., Choi, D. H., Kwon, T. O. and Lee, H. S. 2005. Screening of vasorelaxant activity of some medicinal plants used in Oriental medicines. J. Ethnopharmacol. 99, 113-117. DOI |
12 | Yu, T., Lee, Y. J., Jang, H. J., Kim, A. R., Hong, S., Kim, T. W., Kim, M. Y., Lee, J., Lee, Y. G. and Cho, J. Y. 2011. Anti-inflammatory activity of Sorbus commixta water extract and its molecular inhibitory mechanism. J. Ethnopharmacol. 134, 493-500. DOI |
13 | Zhang, L., Zhang, H., Li, X., Jia, B., Yang, Y., Zhou, P., Li, P. and Chen, J. 2016. Miltirone protects human EA.hy926 endothelial cells from oxidized low-density lipoprotein-derived oxidative stress via a heme oxygenase-1 and MAPK/Nrf2 dependent pathway. Phytomedicine 23, 1806-1813. DOI |
14 | Zhou, P., Xie, W., Luo, Yun., Lu, Shan., Dai, Ziru., Wang, R., Sun, G. and Sun, X. 2019. Protective effects of total saponins of Aralia elata (Miq.) on endothelial cell injury induced by TNF- via modulation of the PI3K/Akt and NF- signaling pathways. Int. J. Mol. Sci. 20, 36. |
15 | Na, M., An, R. B., Min, B. S., Lee, S. M., Kim, Y. H. and Bae, K. 2002. Chemical constituents from Sorbus commixta. Nat. Prod. Sci. 8, 62-65. |
16 | Zhu, L., Yang, X. P., Janic, B., Rhaleb, N. E., Harding, P., Nakagawa, P., Peterson, E. L. and Carretero, O. A. 2016. Ac-SDKP suppresses TNF--induced ICAM-1 expression in endothelial cells via inhibition of kinase and NF- activation. Am. J. Physiol. Heart Circ. Physiol. 310, 1176-1183. |
17 | Kim, D. H., Bang, M. H., Song, M. C., Kim, S. U., Chang, Y. J. and Baek, N. I. 2005. Isolation of -sitosterol, phytol and zingerone 4-O--D-glucopyranoside from Chrysanthemum Boreale Makino. Kor. J. Medicinal Crop Sci. 13, 284-287. |
18 | Kim, D. K., Nam, I. Y., Kim, J. W., Shin, T. Y. and Lim, J. P. 2002. Pentacyclic triterpenoids from IIex macropoda. Arch. Pharm. Res. 25, 617-620. DOI |
19 | Lee, S. G. and Kim, M. M. 2015. Anti-inflammatory Effect of Scopoletin in RAW264.7 macrophages. J. Life Sci. 25, 1377-1383. DOI |
20 | Lee, S. O., Lee, H. W., Lee, I. S. and Im, H. G. 2006. The pharmacological potential of Sorbus commixta cortex on blood alcohol concentration and hepatic lipid peroxidation in acute alcohol-treated rats. J. Pharm. Pharmacol. 58, 685-893. DOI |
21 | Nam, J. H., Choi, S. Z. and Lee, K. R. 2004. Phytochemical constituents of Synurus excelsus. Kor. J. Pharmacogen. 35, 116-121. |
22 | Pan, R., Gao, X. H., Lu, D., Xu, X., Xia, Y. and Dai, Y. 2011. Prevention of FGF-2-induced angiogenesis by scopoletin, a coumarin compound isolated from Erycibe obtusifolia Benth, and its mechanism of action. Int. J. Immunopharmacol. 11, 2007-2016. DOI |
23 | Baeuerle, P. A. and Baltimore, D. 1988. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242, 540-546. DOI |
24 | Park, S. W., Yook, C. S. and Lee, H. K. 1994. Chemical components from the fruits of Crataegus pinnatifida var. psilosa. Kor. J. Pharmacogen. 25, 328-335. |
25 | Price, D. T. and Loscalzo, J. 1999. Cellular adhesion molecules and atherogenesis. Am. J. Med. 107, 85-97. DOI |
26 | Ross, R. 1999. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 340, 115-126. DOI |
27 | Bae, J. T., Shim, G. S., Kim, J. H., Pyo, H. B., Yun, J. W. and Lee, B. C. 2007. Antioxidative activity of the hydrolytic enzyme treated Sorbus commixta Hedl. and its inhibitory effect on matrix metalloproteinase-1 in UV irradiated human dermal fibroblasts. Arch. Pharm. Res. 30, 1116-1123. DOI |