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http://dx.doi.org/10.5352/JLS.2020.30.2.169

Functional Chemical Components and Their Biological Activities of Houttuynia cordata and Lespedeza cuneata  

Park, Seong Ik (Department of Biological Sciences & Biotechnology, Andong National University)
Sohn, Ho-Yong (Department of Food & Nutrition, Andong National University)
Lee, Chang Il (Gyeongsangbuk-do Institute of Health & Environment)
Hwang, Hee Young (Gyeongsangbuk-do Institute of Health & Environment)
Park, Seung Woo (Gyeongsangbuk-do Institute of Health & Environment)
Kim, Jong-Sik (Department of Biological Sciences & Biotechnology, Andong National University)
Publication Information
Journal of Life Science / v.30, no.2, 2020 , pp. 169-177 More about this Journal
Abstract
For this study, we prepared organic solvent fractions from methanol extracts of Houttuynia cordata and Lespedeza cuneate, and analyzed their chemical components and various biological functions such as anti-oxidation, angiotensin-converting enzyme (ACE) inhibition, and α-glucosidase inhibitory activities. We found that DPPH radical scavenging activity was highest in the ethyl acetate fractions of Houttuynia cordata (90.8%) and Lespedeza cuneata (91.2%), whereas ABTS radical scavenging activity was highest in the ethyl acetate fractions of Houttuynia cordata (86.1%) and the chloroform fractions of Lespedeza cuneata (95.6%). FRAP activity was highest in the ethyl acetate fraction of Houttuynia cordata (360.1 mg TE/g) and Lespedeza cuneata (239.2 mg TE/g). ACE inhibitory activity was highest in the chloroform fraction of Houttuynia cordata (13.2%) and Lespedeza cuneata (35.2%). And, α-glucosidase inhibitory activity was highest in the ethyl acetate fraction of Houttuynia cordata (56.3%), and the water residue of Lespedeza cuneata (93.6%). Finally, we investigated the DPPH radical scavenging activity of 20 types of pure compounds identified in Houttuynia cordata and Lespedeza cuneate. The results show that quercetin demonstrates the highest DPPH radical scavenging activity. Overall, these results help us to understand the functional chemical components of Houttuynia cordata and Lespedeza cuneate and the biological effects of these components.
Keywords
${\alpha}$-glucosidase; angiotensin converting enzyme; anti-oxidation; Houttuynia cordata; Lespedeza cuneata;
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