Association of Melanocortin 4 Receptor (MC4R) Genotypes with Fatty Acid Compositions in an Intercross Population between Duroc and Jeju Native Pigs |
Kang, Yong-Jun
(Subtropical Livestock Research Institute, National Institute of Animal Science, RDA)
Kim, Sang-Geum (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Kim, Su-Yeon (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Shin, Moon-Cheol (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Woo, Jae-Hoon (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Kim, Nam-Young (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Shin, Sang-Min (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Choi, Jae-Young (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Yoo, Ji-Hyun (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Park, Nam-Geon (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Yang, Byoung-Chul (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) Cho, In-Cheol (Subtropical Livestock Research Institute, National Institute of Animal Science, RDA) |
1 | Bruun, C. S., Jorgensen, C. B., Nielsen, V. H., Andersson, L. and Fredholm, M. 2006. Evaluation of the porcine melanocortin 4 receptor (MC4R) gene as a positional candidate for a fatness QTL in a cross between Landrace and Hampshire. Anim. Genet. 37, 359-362. DOI |
2 | Chen, M., Wang, A., Fu, J. and Li, N. 2004. Different allele frequencies of MC4R gene variants in Chinese pig breeds. Arch. Anim. Breed. 47, 463-468. DOI |
3 | Choi, J. S., Jin, S. K., Jeong, Y. H., Jung, Y. C., Jung, J. H., Shim, K. S. and Choi, Y. I. 2016. Relationships between single nucleotide polymorphism markers and meat quality traits of duroc breeding stocks in Korea. Asian-australas. J. Anim. Sci. 29, 1229-1238. DOI |
4 | Davoli, R., Braglia, S., Valastro, V., Annarratone, C., Comella, M., Zambonelli, P., Nisi, I., Gallo, M., Buttazzoni, L. and Russo, V. 2012. Analysis of MC4R polymorphism in italian large white and italian duroc pigs: association with carcass traits. Meat Sci. 90, 887-892. DOI |
5 | Folch, J., Lees, M. and Sloane-stanley, G. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497-509. DOI |
6 | Fortin, A., Robertson, W. M. and Tong, A. K. W. 2005. The eating quality of Canadian pork and its relationship with intramuscular fat. Meat Sci. 69, 297-305. DOI |
7 | Han, S. H., Lee, S. S., Ko, M. S., Seong, P. N., Park, B. Y. and Cho, I. C. 2007. Effects of a porcine mc4r polymorphism (892G> A) on carcass traits in commercial pigs. J. Anim. Sci. Technol. 49, 569-576. DOI |
8 | Hong, J. K., Kim, D. W., Cho, K. H., Sa, S. J., Choi, S. H., Kim, Y. H., Park, J. C., Schmidt, G. S., Davis, M. E. and Chung, H. Y. 2015. Effects of genetic variants for the swine FABP3, HMGA1, MC4R, IGF2, and FABP4 genes on fatty acid composition. Meat Sci. 110, 46-51. DOI |
9 | Chao, Z., Wang, F., Deng, C. Y., Wei, L. M., Sun, R. P., Liu, H. L., Liu, Q. W. and Zheng, X. L. 2012. Distribution and linkage disequilibrium analysis of polymorphisms of MC4R, LEP, H-FABP genes in the different populations of pigs, associated with economic traits in line. Mol. Biol. Rep. 39, 6329-6335. DOI |
10 | Kim, K. S., Larsen, N., Short, T., Plastow, G. and Rothschild, M. F. 2000. A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm. Genome. 11, 131-135. DOI |
11 | Kim, K. S., Larsen, N. J. and Rothschild, M. F. 2000. Rapid communication: linkage and physical mapping of the porcine melanocortin-4 receptor (MC4R) gene. J. Anim. Sci. 78, 791-792. DOI |
12 | Kang, W., Cahyadi, M., Park, H. B., Seo, D. W., Jin, S., Kim, S. W., Choi, Y. I., Kim, K. S., Gotoh, T. and Lee, J. H. 2015. Association of variation in the MC4R gene with meat quality traits in a commercial pig population. J. Fac. Agric. Kyushu Univ. 60, 113-118. DOI |
13 | Li, X., Lee, C. K., Choi, B. H., Kim, T. H., Kim, J. J. and Kim, K. S. 2010. Quantitative gene expression analysis on chromosome 6 between Korean native pigs and Yorkshire breeds for fat deposition. Genes Genomics 32, 385-393. DOI |
14 | Rohrer, G. A., Nonneman, D. J., Miller, R. K., Zerby, H. and Moeller, S. J. 2012. Association of single nucleotide polymorphism (SNP) markers in candidate genes and QTL regions with pork quality traits in commercial pigs. Meat Sci. 92, 511-518. DOI |
15 | Ovilo, C., Fernandez, A., Rodriguez, M. C., Nieto, M. and Silio, L. 2006. Association of MC4R gene variants with growth, fatness, carcass composition and meat and fat quality traits in heavy pigs. Meat Sci. 73, 42-47. DOI |
16 | Park, H. B., Han, S. H., Yoo, C. K., Lee, J. B., Kim, J. H., Baek, K. S., Son, J. K., Shin, S. M., Lim, H. T. and Cho, I. C. 2017. Genome scan linkage analysis identifies a major quantitative trait loci for fatty acid composition in longissimus dorsi muscle in an F(2) intercross between Landrace and Korean native pigs. Asian-australas. J. Anim. Sci. 30, 1061-1065. DOI |
17 | Pena, R. N., Ros-Freixedes, R., Tor, M. and Estany, J. 2016. Genetic marker discovery in complex traits: a field example on fat content and composition in pigs. Int. J. Mol. Sci. 17, 2100. DOI |
18 | Piorkowska, K., Tyra, M., Rogoz, M., Ropka-Molik, K., Oczkowicz, M. and Rozycki, M. 2010. Association of the melanocortin-4 receptor (MC4R) with feed intake, growth, fatness and carcass composition in pigs raised in Poland. Meat Sci. 85, 297-301. DOI |
19 | Reardon, W., Mullen, A. M., Sweeney, T. and Hamill, R. M. 2010. Association of polymorphisms in candidate genes with colour, water-holding capacity, and composition traits in bovine M. longissimus and M. semimembranosus. Meat Sci. 86, 270-275. DOI |
20 | Roh, J. G., Kim, S. W., Choi, J. S., Choi, Y. I., Kim, J. J., Choi, B. H., Kim, T. H. and Kim, K. S. 2012. Characterization and evaluation of melanocortin 4 receptor (MC4R) gene effect on pork quality traits in pigs. J. Anim. Sci. Technol. 54, p. 1-8. DOI |
21 | Sambrook, J., Fritsch, E. F. and Maniatis, T. 1989. Isolation of high-molecular-weight DNA from mammalian cells. in: molecular cloning: a laboratory manual. 2nd ed., New York: Cold Spring Harbor, Cold Spring Harbor Laboratory Press. 9.14-9.23. |
22 | Van den Maagdenberg, K., Stinckens, A., Claeys, E., Seynaeve, M., Clinquart, A., Georges, M., Buys, N. and De Smet, S. 2007. The Asp298Asn missense mutation in the porcine melanocortin-4 receptor (MC4R) gene can be used to affect growth and carcass traits without an effect on meat quality. Animal 1, 1089-1098. DOI |
23 | Wang, W., Xue, W., Jin, B., Zhang, X., Ma, F. and Xu, X. 2013. Candidate gene expression affects intramuscular fat content and fatty acid composition in pigs. J. Appl. Genet. 54, 113-118. DOI |
24 | Zhang, W., Zhang, J., Cui, L., Ma, J., Chen, C., Ai, H., Xie, X., Li, L., Xiao, S., Huang, L., Ren, J. and Yang, B. 2016. Genetic architecture of fatty acid composition in the longissimus dorsi muscle revealed by genome-wide association studies on diverse pig populations. Genet. Sel. Evol. 48, 5. DOI |
25 | Zhang, J., Chai, J., Luo, Z., He, H., Chen, L., Liu, X. and Zhou, Q. 2018. Meat and nutritional quality comparison of purebred and crossbred pigs. Anim. Sci. J. 89, 202-210. DOI |