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http://dx.doi.org/10.5352/JLS.2019.29.8.846

Increased Antioxidative Activity of Fermented Ligusticum striatum Makino Ethanol Extract by Bioconversion using Lactobacillus plantarum BHN-LAB 129  

Kim, Byung-Hyuk (Institute for Development of Bio-industrial Materials, BHNBIO Co., LTD.)
Jeong, Su Jin (Institute for Development of Bio-industrial Materials, BHNBIO Co., LTD.)
Jang, Jong-Ok (Division of Horticulture & Medicinal Plant, Andong National University)
Lee, Jun-Hyeong (Institute for Development of Bio-industrial Materials, BHNBIO Co., LTD.)
Park, YeEun (Institute for Development of Bio-industrial Materials, BHNBIO Co., LTD.)
Kim, Jung-Gyu (Institute for Development of Bio-industrial Materials, BHNBIO Co., LTD.)
Kwon, Gi-Seok (Division of Horticulture & Medicinal Plant, Andong National University)
Hwang, Hak-Soo (Kyochon F&B Co., LTD.)
Lee, Jung-Bok (Institute for Development of Bio-industrial Materials, BHNBIO Co., LTD.)
Publication Information
Journal of Life Science / v.29, no.8, 2019 , pp. 846-853 More about this Journal
Abstract
Phytochemical compounds of Ligusticum striatum Makino are used as traditional medicinal herbs in Asia. These compounds are reported to have pain relief and antioxidant activities in gynecological and brain diseases. In this study, we investigated the antioxidant effects of Ligusticum fermented ethanol extract from Lactobacillus plantarum BHN-LAB 129 isolated from Kimchi, a Korean traditional food. The total polyphenol and total flavonoid contents increased by about 116.2% and 281.0% respectively, in the fermented Ligusticum extract as compared with those in the nonfermented Ligusticum ethanol extract. Superoxide dismutase-like (SOD), DPPH radical scavenging, ABTS radical scavenging, and reducing power activities increased by around 139.9%, 199.6%, 301.0%, and 137.1%, respectively, in the fermented Ligusticum ethanol extract as compared with these parameters in the nonfermented Ligusticum ethanol extract, respectively. In conclusion, the fermented Ligusticum ethanol extract with L. plantarum BHN-LAB 129 was effective in increasing the antioxidant effects. The bioconversion process in this study points to the potential of using Ligusticum to produce phytochemical-enriched natural antioxidant agents with high added value. The findings may prove useful in the development of improved foods and cosmetic materials.
Keywords
Anti-oxidant; fermentation; lactic acid bacteria; Lactobacillus sp.; Ligusticum;
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1 Waltenberger, B., Halabalaki, M., Schwaiger, S., Adamopoulos, N., Allouche, N., Fiebich, B. L., Hermans, N., Jansen-Durr, P., Kesternich, V., Pieters, L., Schonbichler, S., Skaltsounis, A. L., Tran, H., Trougakos, I. P., Viljoen, A., Wolfender, J. L., Wolfrum, C., Xynos, N. and Stuppner, H. 2018. Novel natural products for healthy ageing from the mediterranean diet and food plants of other global sources-The MediHealth Project. Molecules 23, 1097.   DOI
2 Yoon, Y. C., Kim, B. H., Kim, J. K., Lee, J. H., Park, Y. E., Kwon, G. S., Hwang, H. S. and Lee, J. B. 2018. Verification of biological activities and tyrosinase inhibition of ethanol extracts from Hemp Seed (Cannabis sativa L.) fermented with lactic acid bacteria. J. Life Sci. 28, 688-696.   DOI
3 Zhishen, J., Mengcheng, T. and Jianming, W. 1999. The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals. Food Chem. 64, 555-559.   DOI
4 Jung, H. K., Kim, E. Y., Yae, H. S., Choi, S. J., Jung, J. Y. and Juhn, S. L. 2000. Cholesterol-lowering effect of lactic acid bacteria and fermented milks as probiotic functional foods. Food Ind. Nutr. 5, 29-35.
5 Kim, B. H., Jang, J. O., Joa, J. H., Kim, J. A., Song, S. Y., Lim, C. K., Kim, C. H., Jung, Y. B., Seong, K. C., Kim, H. S. and Moon, D. G. 2017. A comparison of the microbial diversity in Korean and Chinese post-fermented teas. Microbiol. Biotechnol. Lett. 45, 71-80.   DOI
6 Kim, B. H., Jang, J. O., Lee, J. H., Park, Y. E., Kim, J. G., Yoon, Y. C., Jeong, S. J., Kwon, G. S. and Lee, J. B. 2019. Bioconversion of glycosides isoflavone to aglycone isoflavone by Lactobacillus rhamnosus BHN-LAB 76 in the anaerobic conditions. Kor. J. Food Preserv. 26, 148-156.   DOI
7 Kim, B. H., Jang, J. O., Lee, J. H., Park, Y., Kim, J. G., Yoon, Y. C., Jeong, S. J., Kwon, G. S. and Lee, J. B. 2019. Increased anti-oxidative activity and whitening effect of fermented Saposhnikovia extract by bioconversion using Lactobacillus plantarum BHN-LAB 33. J. Life Sci. in press.
8 Kim, E. J., Choi, J. Y., Yu, M. R., Kim, M. Y., Lee, S. H. and Lee, B. H. 2012. Total polyphenols, total flavonoid contents, and antioxidant activity of Korean natural and medicinal plants. Kor. J. Food Sci. Technol. 44, 337-342.   DOI
9 Kim, J. M., Son, D., Lee, P., Lee, K. J., Kim, H. and Kim, S. Y. 2003. Ethyl acetate soluble fraction of Cnidium officinale Makino inhibits neuronal cell death by reduction of excessive nitric oxide production in lipopolysaccharide-treated rat hippocampal slice cultures and microglia cells. J. Pharmacol. Sci. 92, 74-78.   DOI
10 Kim, S. I., Sim, K. H., Ju, S. Y. and Han, Y. S. 2009. A study on antioxidative and hypoglycemic activities of Omija (Schizandra chinensis Baillon) extract under variable extract conditions. Kor. J. Food Nutr. 22, 41-47.
11 Marklund, S. and Marklund, G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. FEBS J. 47, 469-474.
12 Lee, M. Y., Yoo, M. S., Whang, Y. J., Jin, Y. J., Hong, M. H. and Pyo, Y. H. 2012. Vitamin C, total polyphenol, flavonoid contents and antioxidant capacity of several fruit peels. Kor. J. Food Sci. Technol. 44, 540-544.   DOI
13 Lee, W. H., Han, S. R., Yu, S. C. and Oh, T. J. 2018. Comparison of physiological activities of Flammulina velutipes according to solvent extractions. J. Kor. Soc. Food Sci. Nutr. 47, 83-89.   DOI
14 Linares, D. M., Gomez, C., Renes, E., Fresno, J. M., Tornadijo, M. E., Ross, R. P. and Stanton, C. 2017. Lactic acid bacteria and Bifidobacteria with potential to design natural biofunctional health-promoting dairy foods. Front. Microbiol. 8, 846.   DOI
15 Oh, Y. J., Seo, H. R., Choi, Y. M. and Jung, D. S. 2010. Evaluation of antioxidant activity of the extracts from the aerial parts of Cnidium officinale Makino. Kor. J. Medicinal Crop Sci. 18, 373-378.
16 Poojary, M. M., Dellarosa, N., Roohinejad, S., Koubaa, M., Tylewicz, U., Gomez-Galindo, F., Saraiva, J. A., Rosa, M. D. and Barba, F. J. 2017. Influence of innovative processing on ${\gamma}$-aminobutyric acid (GABA) contents in plant food materials. Compr. Rev. Food Sci. F. 16, 895-905.   DOI
17 Oyaizu, M. 1986. Studies on product of browning reaction prepared from glucose amine. Jap. J. Nutr. 44, 307-315.   DOI
18 Pandey, S., Parvez, S., Sayeed, I., Haque, R., Bin-Hafeez, B. and Raisuddin, S. 2003. Biomarkers of oxidative stress: a comparative study of river Yamuna fish Wallago attu. (Bl. & Schn.). Sci. Total Environ. 309, 105-115.   DOI
19 Park, Y. E., Kim, B. H., Yoon, Y. C., Kim, J. K., Lee, J. H., Kwon, G. S., Hwang, H. S. and Lee, J. B. 2018. Total polyphenol contents, flavonoid contents, and antioxidant activity of roasted-flaxseed extracts based on lactic-acid bacteria fermentation. J. Life Sci. 28, 547-554.   DOI
20 Park, Y. E., Kwon, G. S., Kim, B. H. and Lee, J. B. 2019. Evaluation of the usefulness of the fermented Thistle (Cirsium japonicum ) with Lactobacillus rhamnosus BHN-LAB 105 for antioxidative and whitening effects. Asian J. Beauty Cosmetol. 17, 1-13.   DOI
21 Saez-Lara, M. J., Gomez-Llorente, C., Plaza-Diaz, J. and Gil, A. 2015. The role of probiotic lactic acid bacteria and Bifidobacteria in the prevention and treatment of inflammatory bowel disease and other related diseases: A systematic review of randomized human clinical trials. Biomed. Res. Int. 2015, 505-878.
22 Shin, M. J., Lee, J. E. and Seo, E. W. 2015. Stress resistance of Zacco koreanus due to exposure of cement powder. J. Life Sci. 25, 615-623.   DOI
23 Saito, M., Sakagami, H. and Fujisawa, S. 2002. Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT). Anticancer Res. 23, 4693-4701.
24 Samak, G., Shenoy, R. P., Manjunatha, S. M. and Vinayak, K. S. 2009. Superoxide and hydroxyl radical scavenging actions of botanical extracts of Wagatea spicata. Food Chem. 115, 631-634.   DOI
25 Santos, V. A. Q., Nascimento, C. G., Schmidt, C. A. P., Mantovani, D., Dekker, R. F. H. and Cunha, M. A. A. d. 2018. Solid-state fermentation of soybean okara: Isoflavones biotransformation, antioxidant activity and enhancement of nutritional quality. LWT - Food Sci. Technol. 92, 509-515.   DOI
26 Smeriglio, A., Galati, E. M., Monforte, M. T., Lanuzza, F., D'angelo, V. and Circosta, C. 2016. Polyphenolic compounds and antioxidant activity of cold-pressed seed oil from finola cultivar of cannabis sativa l. Phytother. Res. 30, 1298-1307.   DOI
27 Forney, L. J., Zhou, X. and Brown, C. J. 2004. Molecular microbial ecology: land of the one-eyed king. Curr. Opin. Microbiol. 7, 210-220.   DOI
28 Ann, Y. G. 2011. Probiotic lactic acid bacteria. Kor. J. Food Nutr. 24, 817-832.   DOI
29 Blois, M. S. 1958. Antioxidant determinations by the use of a stable free radical. Nature 121, 1999.
30 Castillo, M., Martin-Orue, S. M., Manzanilla, E. G., Badiola, I., Martin, M. and Gasa, J. 2005. Quantification of total bacteria, enterobacteria and lactobacilli populations in pig digesta by real-time PCR. Vet. Microbiol. 114, 165-170.   DOI
31 Gheldof, N. and Engeseth, N. J. 2002. Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum J. Agric. Food Chem. 50, 3050-3055.   DOI
32 Han, S. R., Noh, M. Y., Lee, J. H. and Oh, T. J. 2015. Evaluation of antioxidant and antimicrobial activities of solvent extracts from Coriolus versicolor. J. Kor. Soc. Food Sci. Nutr. 44, 1793-1798.   DOI
33 Holasova, M., Fiedlerova, V., Smrcinova, H., Orsak, M., Lachman, J. and Vavreinova, S. 2002. Buckwheat-the source of antioxidant activity in functional foods. Food Res. Int. 35, 207-211.   DOI
34 Vrijheid, M., Casas, M., Gascon, M., Valvi, D. and Nieuwenhuijsen, M. 2016. Environmental pollutants and child health-A review of recent concerns. Int. J. Hyg. Envir. Heal. 219, 331-342.   DOI
35 Imai, J., Ide, N., Nagae, S., Moriguchi, T., Matsuura, H. and Itakura, Y. 1994. Antioxidant and radical scavenging effects of aged garlic extract and its constituents. Planta Med. 60, 417-420.   DOI
36 Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M. and Kumar, S. 2011. MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28, 2731-2739.   DOI