Shin, Ji Eun
(Department of Molecular Biology, College of Natural Sciences, Pusan National University)
Lee, Kyungmin (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Kim, Ji-Hee (BK21Plus Research Group for Longevity and Marine Biotechnology, Pusan National University) Madhi, Iskander (Department of Molecular Biology, College of Natural Sciences, Pusan National University) Kim, YoungHee (Department of Molecular Biology, College of Natural Sciences, Pusan National University) |
1 | Kim, J. H., Park, G. Y., Bang, S. Y., Park, S. Y., Bae, S. K. and Kim, Y. 2014. Crocin suppresses LPS-stimulated expression of inducible nitric oxide synthase by upregulation of heme oxygenase-1 via calcium/calmodulin-dependent protein kinase 4. Mediators Inflamm. 2014, 728709. |
2 | Lee, J. S., Song, J. H., Sohn, N. W. and Shin, J. W. 2013. Inhibitory effects of ginsenoside Rb1 on neuroinflammation following systemic lipopolysaccharide treatment in mice. Phytother. Res. 27, 1270-1276. DOI |
3 | Lee, K. W., Jung, S. Y., Choi, S. M. and Yang, E. J. 2012. Effects of ginsenoside re on LPS-induced inflammatory mediators in BV2 microglial cells. BMC Complement. Altern. Med. 12, 196. DOI |
4 | Lee, Y. Y., Park, J. S., Lee, E. J., Lee, S. Y., Kim, D. H., Kang, J. L. and Kim, H. S. 2015. Anti-inflammatory mechanism of ginseng saponin metabolite Rh3 in lipopolysaccharide-stimulated microglia: Critical role of 5'-adenosine monophosphate-activated protein kinase signaling pathway. J. Agric. Food Chem. 63, 3472-3480. DOI |
5 | Lin, W. M., Zhang, Y. M., Moldzio, R. and Rausch, W. D. 2007. Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture. J. Neural Transm. Suppl. 72, 105-112. DOI |
6 | Liu, Y., Yin, H., Zhao, M. and Lu, Q. 2014. TLR2 and TLR4 in autoimmune diseases: A comprehensive review. Clin. Rev. Allergy Immunol. 47, 136-147. DOI |
7 | Lull, M. E. and Block, M. L. 2010. Microglial activation and chronic neurodegeneration. Neurotherapeutics 7, 354-365. DOI |
8 | Motohashi, H., Katsuoka, F., Engel, J. D. and Yamamoto, M. 2004. Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway. Proc. Natl. Acad. Sci. USA. 101, 6379-6384. DOI |
9 | Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A. and Choi, A. M. 2000. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat. Med. 6, 422-428. DOI |
10 | Nemmiche, S., Chabane-Sari, D., Kadri, M. and Guiraud, P. 2012. Cadmium-induced apoptosis in the BJAB human B cell line: Involvement of PKC/ERK1/2/JNK signaling pathways in HO-1 expression. Toxicology 300, 103-111. DOI |
11 | Segain, J. P., Raingeard, de la Bletiere, D., Bourreille, A., Leray, V., Gervois, N., Rosales, C., Ferrier, L., Bonnet, C., Blottiere, H. M. and Galmiche, J. P. 2000. Butyrate inhibits inflammatory responses through NFkappaB inhibition: Implications for crohn's disease. Gut 47, 397-403. DOI |
12 | Park, J. S., Shin, J. A., Jung, J. S., Hyun, J. W., Van Le, T. K., Kim, D. H., Park, E. M. and Kim, H. S. 2012. Anti-inflammatory mechanism of compound K in activated microglia and its neuroprotective effect on experimental stroke in mice. J. Pharmacol. Exp. Ther. 341, 59-67. DOI |
13 | Ryter, S. W. and Choi, A. M. 2010. Heme oxygenase-1/carbon monoxide: Novel therapeutic strategies in critical care medicine. Curr. Drug Targets 11, 1485-1494. DOI |
14 | Schwandner, R., Dziarski, R., Wesche, H., Rothe, M. and Kirschning, C. J. 1999. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 274, 17406-17409. DOI |
15 | Shin, H. R., Kim, J. Y., Yun, T. K., Morgan, G. and Vainio, H. 2000. The cancer-preventive potential of Panax ginseng: A review of human and experimental evidence. Cancer Causes Control 11, 565-576. DOI |
16 | Neher, J. J. and Brown, G. C. 2007. Neurodegeneration in models of Gram-positive bacterial infections of the central nervous system. Biochem. Soc. Trans. 35, 1166-1167. DOI |
17 | Bal-Price, A. and Brown, G. C. 2001. Inflammatory neurodegeneration mediated by nitric oxide from activated gliainhibiting neuronal respiration, causing glutamate release and excitotoxicity. J. Neurosci. 21, 6480-6491. DOI |
18 |
Ahn, K. S. and Aggarwal, B. B. 2005. Transcription factor NF- |
19 | Andrews, N. C. and Faller, D. V. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19, 2499. DOI |
20 | Attele, A. S., Wu, J. A. and Yuan, C. S. 1999. Ginseng pharmacology: Multiple constituents and multiple actions. Biochem. Pharmacol. 58, 1685-1693. DOI |
21 | Bhattacharya, S. K. and Mitra, S. K. 1991. Anxiolytic activity of Panax ginseng roots: An experimental study. J. Ethnopharmacol. 34, 87-92. DOI |
22 | Blackwell, T. S., Blackwell, T. R., Holden, E. P., Christman, B. W. and Christman, J. W. 1996. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J. Immunol. 157, 1630-1637. |
23 | Block, K. I. and Mead, M. N. 2003. Immune system effects of echinacea, ginseng, and astragalus: A review. Integr. Cancer Ther. 2, 247-267. DOI |
24 | Doherty, G. H. 2011. Nitric oxide in neurodegeneration: Potential benefits of non-steroidal anti-inflammatories. Neurosci. Bull. 27, 366-382. DOI |
25 | Van Eldik, L. J., Thompson, W. L., Ralay Ranaivo, H., Behanna, H. A. and Martin Watterson, D. 2007. Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: Function-based and target-based discovery approaches. Int. Rev. Neurobiol. 82, 277-296. DOI |
26 | Gillis, C. N. 1997. Panax ginseng pharmacology: A nitric oxide link? Biochem. Pharmacol. 54, 1-8. DOI |
27 | Srisook, K., Kim, C. and Cha, Y. N. 2005. Molecular mechanisms involved in enhancing HO-1 expression: De-repression by heme and activation by Nrf2, the "one-two" punch. Antioxid. Redox Signal. 7, 1674-1687. DOI |
28 | Sun, X. C., Ren, X. F., Chen, L., Gao, X. Q., Xie, J. X. and Chen, W. F. 2016. Glucocorticoid receptor is involved in the neuroprotective effect of ginsenoside Rg1 against inflammation-induced dopaminergic neuronal degeneration in substantia nigra. J. Steroid Biochem Mol. Biol. 155, 94-103. DOI |
29 | Sun, Z., Huang, Z. and Zhang, D. D. 2009. Phosphorylation of Nrf2 at multiple sites by MAP kinases has a limited contribution in modulating the Nrf2-dependent antioxidant response. PLoS One 4, e6588. DOI |
30 | Tieu, K., Ischiropoulos, H. and Przedborski, S. 2003. Nitric oxide and reactive oxygen species in parkinson's disease. IUBMB Life 55, 329-335. DOI |
31 | Wakabayashi, C., Murakami, K., Hasegawa, H., Murata, J. and Saiki, I. 1998. An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem. Biophys. Res. Commun. 246, 725-730. DOI |
32 | Wei, T., Chen, C., Hou, J., Xin, W. and Mori, A. 2000. Nitric oxide induces oxidative stress and apoptosis in neuronal cells. Biochim. Biophys. Acta 1498, 72-79. DOI |
33 | Yang, Y., Yang, W. S., Yu, T., Sung, G. H., Park, K. W., Yoon, K., Son, Y. J., Hwang, H., Kwak, Y. S., Lee, C. M., Rhee, M. H., Kim, J. H. and Cho, J. Y. 2014. ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract. J. Ethnopharmacol. 154, 218-228. DOI |
34 | Kang, A., Hao, H., Zheng, X., Liang, Y., Xie, Y., Xie, T., Dai, C., Zhao, Q., Wu, X., Xie, L. and Wang, G. 2011. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy. J. Neuroinflammation 8, 100. DOI |
35 | Giridharan, S. and Srinivasan, M. 2018. Mechanisms of NF-kappaB p65 and strategies for therapeutic manipulation. J. Inflamm. Res. 11, 407-419. DOI |
36 | He, M., Huang, X., Liu, S., Guo, C., Xie, Y., Meijer, A. H. and Wang, M. 2018. The difference between white and red ginseng: Variations in ginsenosides and immunomodulation. Planta Med. 84, 845-854. DOI |
37 | Jazwa, A. and Cuadrado, A. 2010. Targeting heme oxygenase-1 for neuroprotection and neuroinflammation in neurodegenerative diseases. Curr. Drug Targets 11, 1517-1531. DOI |
38 | Jiang-Shieh, Y. F., Yeh, K. Y., Wei, I. H., Chang, C. Y., Chien, H. F., Tsai, R. Y., Chang, M. L., Lee, A. W., Pai, M. H. and Wu, C. H. 2005. Responses of microglia in vitro to the gram-positive bacterial component, lipoteichoic acid. J. Neurosci. Res. 82, 515-524. DOI |
39 | Jin, Y., Kotakadi, V. S., Ying, L., Hofseth, A. B., Cui, X., Wood, P. A., Windust, A., Matesic, L. E., Pena, E. A., Chiuzan, C., Singh, N. P., Nagarkatti, M., Nagarkatti, P. S., Wargovich, M. J. and Hofseth, L. J. 2008. American ginseng suppresses inflammation and DNA damage associated with mouse colitis. Carcinogenesis 29, 2351-2359. DOI |
40 | Kang, A., Xie, T., Zhu, D., Shan, J., Di, L. and Zheng, X. 2017. Suppressive effect of ginsenoside Rg3 against lipopolysaccharide-induced depression-like behavior and neuroinflammation in mice. J. Agric. Food Chem. 65, 6861-6869. DOI |
41 | Keyse, S. M. and Tyrrell, R. M. 1989. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. USA. 86, 99-103. DOI |
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