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http://dx.doi.org/10.5352/JLS.2019.29.1.52

Evaluation of the Bioactivity of Polygonium tinctorium Leaf: Potential Clinical Uses  

Sung, Hwa-Jung (Department of Food and Nutrition, Andong National University)
Choi, Ok-Ja (Indigo World Gallery)
Park, Jong-Yi (Gyeongbuk Institute For Bio-Industry)
Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University)
Publication Information
Journal of Life Science / v.29, no.1, 2019 , pp. 52-59 More about this Journal
Abstract
The leave of Polygonum tinctorium (LPT) have been used for centuries as a traditional medicine and as a food ingredient and natural dye. The aim of the current study was to develop high-value added products using LPT. Hot water extract (HWE) and ethanol extract (EE) of LPT were prepared, respectively, and their bioactivity was evaluated. The extraction ratio for the HWE was 27.6%, which was two-fold higher than that of the EE. The contents of total polyphenol in the HWE and total sugar in the EE were 51.2 mg/g and 297.8 mg/g, respectively. The total flavonoid and reducing sugar contents were similar in the extracts, irrespective of the extraction solvent. The HWE did not show antimicrobial activity in a disc-diffusion assay, but the EE showed strong growth inhibition against gram-positive bacteria. The EE exhibited stronger DPPH and ABTS radical scavenging activities and reducing power than those of the HWE. The HWE was particularly effective as a scavenger of nitrite ($RC_{50}$ of $6.0{\mu}g/ml$). In an antithrombosis activity assay, the EE showed significant anticoagulation activity as determined by an extended blood coagulation time (thrombin time, prothrombin time, and activated partial thromboplastin time), in addition to platelet aggregation activity. The HWE also showed platelet aggregation inhibitory activity. This report provides the first evidence of antithrombosis activities of LPT. Our results suggest that LPT has potential as a new antioxidant and antithrombosis agent.
Keywords
Anti-microbial; anti-oxidation; anti-thrombosis; Polygonium tinctorium;
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Times Cited By KSCI : 7  (Citation Analysis)
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