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http://dx.doi.org/10.5352/JLS.2018.28.6.738

Anti-oxidant and Anti-inflammatory Potentials of Sasa quelpaertensis Leaf Residue Extracts  

Lee, Ju-Yeop (Jeju Sasa Industry Development Agency, Jeju National University)
Song, Hana (Jeju Sasa Industry Development Agency, Jeju National University)
Ko, Hee-Chul (Jeju Sasa Industry Development Agency, Jeju National University)
Jang, Mi-Gyeong (Department of Biology, Jeju National University)
Kim, Se-Jae (Jeju Sasa Industry Development Agency, Jeju National University)
Publication Information
Journal of Life Science / v.28, no.6, 2018 , pp. 738-744 More about this Journal
Abstract
Sasa quelpaertensis Nakai is a native Korean plant that grows only on Mt. Halla of Jeju Island. Its leaf is used for a popular bamboo tea due to its various health-promoting properties, and it has been increasingly used as food and cosmetic ingredients. To utilize the S. quelpaertensis leaf efficiently, the preparation method for phytochemical-rich extract (PRE) using the leaf's residue was previously reported, which was produced after hot water extraction. This study was undertaken to evaluate the anti-oxidant and anti-inflammatory potential of PRE and its solvent fractions. The ethyl acetate fraction of PRE (EPRE) showed higher DPPH, ABTS, and superoxide radical scavenging activities, and it effectively inhibited intracellular reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharides (LPS)-stimulated RAW 264.7 cells. EPRE also induced the expression of heme oxygenase-1 (HO-1) by increasing the level of nuclear factor E2-related factor 2 (Nrf2) in a nuclear fraction. The inhibiting effect of EPRE on LPS-induced NO production was partially reversed by the HO-1 inhibitor (zinc protoporphyrin, ZPP), suggesting that HO-1 is involved in suppressing NO production. Taken together, the results suggest that EPRE has potential as a promising anti- oxidant and anti-inflammatory agent.
Keywords
Anti-inflammatory; anti-oxidant; heme oxygenase-1; Sasa quelpaertensis;
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1 Lee, J. Y., Ko, H. C., Jang, M. K. and Kim, S. J. 2016. Preparation and characterization of phytochemical-rich extract from Sasa quelpaertensis leaf. J. Life Sci. 26, 1330-1335.   DOI
2 Li, L., Grenard, P., Nhieu, J. T., Julien, B., Mallat, A., Habib, A. and Lotersztajn, S. 2003. Heme oxygenase-1 is an antifibrogenic protein in human hepatic myofibroblasts. Gastroenterology 125, 460-469.   DOI
3 Lin, H. Y., Juan, S. H., Shen, S. C., Hsu, F. L. and Chen, Y.C. 2003. Inhibition of lipopolysaccharide-induced nitric oxide production by flavonoids in RAW264.7 macrophages involves heme oxygenase-1. Biochem. Pharmacol. 66, 1821-1832.   DOI
4 Loboda, A. Jazwa, A., Grochot-Przeczek, A., Rutkowski, A. J., Cisowski, J., Agarwal, A., Jozkowicz, A. and Dulak, J. 2008. Heme oxygenase-1 and the vascular bed: from molecular mechanisms to therapeutic opportunities. Antioxid. Redox Signal. 10, 1767-1812.   DOI
5 Okabe, S., Takeuchi, K., Takagi, K. and Shibata, M. 1975. Stimulatory effect of the water extract of bamboo grass (Folin solution) on gastric acid secretion in pylorus-ligated rats. Jpn. J. Pharmacol. 25, 608-609   DOI
6 Otterbein, L. E. and Choi, A. M. 2000. Heme oxygenase: colors of defense against cellular stress. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, 1029-1037.   DOI
7 Ren, M., Reilly, R. T. and Sacchi, N. 2004. Sasa health exerts a protective effect on Her2/NeuN mammary tumorigenesis. Anticancer Res. 24, 2879-2884
8 Ryter, S. W., Otterbein, L. E., Morse, D. and Choi, A. M. 2002. Heme oxygenase/carbon monoxide signaling pathways: regulation and functional significance. Mol. Cell Biochem. 235, 249-263.
9 Sies, H. 2015. Oxidative stress: a concept in redox biology and medicine. Redox. Biol. 4, 180-183.   DOI
10 Srisook, K., Kim, C. and Cha, Y. N. 2005. Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch. Antioxid. Redox Signal. 7, 1674-1687.   DOI
11 Tamion, F., Richard, V., Bonmarchand, G., Leroy, J., Lebreton, J. P. and Thuillez, C. 2001. Induction of heme-oxygenase-1 prevents the systemic responses to hemorrhagic shock. Am. J. Respir. Crit. Care Med. 164, 1933-1938.   DOI
12 Hensley, K., Robinson, K. A., Gabitta, S. P., Salsman, S. and Floyd, R. A. 2000. Reactive oxygen species, cell signaling, and cell injury. Free Rad. Biol. Med. 28, 1456-1462.   DOI
13 Wojcik, M., Burzynska-Pedziwiatr, I. and Wozniak, L. A. 2010. A review of natural and synthetic antioxidants important for health and longevity. Curr. Med. Chem. 17, 3262-3688.   DOI
14 Yoon, S. A., Kang, S. I., Shin, H. S., Kang, S. W., Kim, J. H., Ko, H. C. and Kim, S. J., 2013. p-Coumaric acid modulates glucose and lipid metabolism via AMP-activated protein kinase in L6 skeletal muscle cells. Biochem. Biophys. Res. Commun. 432, 553-557.   DOI
15 Abraham, N. G. and Kappas, A. 2008. Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev. 60, 79-127.   DOI
16 Bae, K. 2000. The Medicinal plants of Korea, pp.565-567, Kyo-Hak Publishing Company, Seoul, Republic of Korea.
17 Bornman, L., Baladi, S., Richard, M. J., Tyrrell, R. M. and Polla, B. S. 1999. Differential regulation and expression of stress proteins and ferritin in human monocytes. J. Cell Physiol. 178, 1-8.   DOI
18 Coleman, J. W. 2001. Nitric oxide in immunity and inflammation. Int. Immnopharmacol. 1, 1397-1406.   DOI
19 Hasegawa, T., Tanaka, A., Hosoda, A., Takano, F. and Ohta, T. 2008. Antioxidant C-glycosylflavones from the leaves of Sasa kurilensis var. gigantea. Phytochemistry 69, 1419-1424.   DOI
20 Hayashi, K., Lee, J. B., Kurosaki, Y., Nozawa, M., Asai, S., Takeshita, K. and Hayashi, T. 2014. Evaluation of fractions and isolated polysaccharides from Sasa veitchii for their preventive effects on influenza A virus infection. J. Funct. Foods 10, 25-34.   DOI
21 Hwang, J. H., Choi, S. Y., Ko, H. C., Jang, M. G., Jin, Y. J., Kang, S. I., Park, J. G., Chung, W. S. and Kim, S. J. 2007. Anti-inflammatory effect of the hot water extract from Sasa quelpaertensis leaves. Food Sci. Biotechnol. 16, 728-733.
22 Jang, M. G., Park, S. Y., Lee, S. R., Choi, S. Y., Hwang, J. H., Ko, H. C., Park, J. G., Chung, W. S. and Kim, S. J. 2008. Sasa quelpaertensis leaf extracts induce apoptosis in human leukemia HL-60 cells. Food Sci. Biotechnol. 17, 188-190.
23 Jeong, Y. H., Chung, S. Y., Han, A. R., Sung, M. K., Jang, D. S., Lee, J., Kwon, Y., Lee, H. J. and Seo, E. K. 2007. P-glycoprotein inhibitory activity of two phenolic compounds, (-)-syringaresinol and tricin from Sasa borealis. Chem. Biodivers. 4, 12-16.   DOI
24 Laskin, D. L. and Pendino, K. J. 1995. Macrophages and inflammatory mediators in tissue injury. Annu. Rev. Pharmacol. Toxicol. 35, 655-677.   DOI
25 Kang, H. and Lee, C. 2015. Sasa quelpaertensis Nakai extract suppresses porcine reproductive and respiratory syndrome virus replication and modulates virus-induced cytokine production. Arch. Virol. 160, 1977-1988.   DOI
26 Kang, S. I., Shin, H. S., Kim, H. M., Hong, Y. S., Yoon, S. A., Kang, S. W., Kim, J. H., Ko, H. C. and Kim, S. J. 2012. Anti-obesity properties of a Sasa quelpaertensis extract in high-fat diet-induced obese mice. Biosci. Biotechnol. Biochem. 76, 755-761.   DOI