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http://dx.doi.org/10.5352/JLS.2018.28.6.671

Hypoglycemic and Hypolipidemic Effects of Jerusalem artichoke Composites in Streptozotocin induced Diabetic Rats  

Hu, Wen-Si (Department of Food Science and Nutrition, Gyeongsang National University)
Lee, Soo-Jung (Institute of Agriculture and Life Science, Gyeongsang National University)
Pyo, Jae-Ho (Sancheong of Functional Bean Farming Union Corporation)
Kim, Sung-Hee (Department of Food Science and Nutrition, Gyeongsang National University)
Sung, Nak-Ju (Department of Food Science and Nutrition, Gyeongsang National University)
Publication Information
Journal of Life Science / v.28, no.6, 2018 , pp. 671-680 More about this Journal
Abstract
Hypoglycemic and hypolipidemic effects of Jerusalem artichoke composites (JAP) with extracts of G. procumbens (12.5%), M. charantia (12.5%), and C. longa (12.5%) to H. tuberosus concentrate (JA, 50%) were evaluated in streptozotocin (STZ) induced diabetic rats. Rats were divided into seven groups: normal (Normal), diabetic control (Diabetic), group fed G. procumbens extract (0.5 g/kg bw, D-GPE), group fed JAP (0.5 g/kg bw, D-JAP1; 1.5 g/kg bw, D-JAP2), group fed JA (0.5 g/kg bw, D-JA), and group fed Metformin (0.2 g/kg bw, D-MET) as a positive control. The blood glucose levels over 4 weeks were significantly decreased in the D-JAP2 and D-MET groups compared to the other groups after 3 weeks. The serum insulin level was not significant among the groups fed an experimental diet, but the HOMA-IR value was significantly decreased compared to the diabetic control group. AST and ALT activities in the serum were lowest in D-JAP1. Total lipid and triglyceride contents in the serum decreased in the groups fed an experimental diet, and the HDL-C contents of D-GPE, D-JAP1, and D-JAP2 were significantly increased compared to the diabetic control group. Triglyceride contents in the liver tissue were significantly lower in the D-GPE, D-JAP1, and D-JAP2 groups, and hepatic TBARS content was significantly decreased in the D-JAP1 and D-JAP2 groups compared to the diabetic control group. Hepatic antioxidative enzyme levels, such as SOD, catalase, and GSH-Px, were significantly elevated in groups fed an experimental diet compared to the diabetic control group. Therefore, JAP may be more effective than JA in the human body due to its hypoglycemic and hypolipidemic activities.
Keywords
Gynura procumbens; hypoglycemic; hypolipidemic; Jerusalem artichoke composite;
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Times Cited By KSCI : 11  (Citation Analysis)
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