Socheongja and Socheong 2 Extracts Suppress Lipopolysaccharide-induced Inflammation and Oxidative Stress in RAW 264.7 Macrophages through Activating Nrf2/HO-1 Signaling and Suppressing MAPKs Pathway
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Kwon, Da Hye
(Open Laboratory for Muscular & Skeletal Disease Control and Department of Biochemistry, Dongeui University College of Korean Medicine)
Choi, Eun Ok (Open Laboratory for Muscular & Skeletal Disease Control and Department of Biochemistry, Dongeui University College of Korean Medicine) Hwang, Hye-Jin (Department of Food and Nutrition, College of Nursing, Healthcare Sciences & Human Ecology, Dongeui University) Kim, Kook Jin (Genomine Advanced Biotechnology Research Institute, Genomine Inc.) Hong, Su Hyun (Open Laboratory for Muscular & Skeletal Disease Control and Department of Biochemistry, Dongeui University College of Korean Medicine) Lee, Dong Hee (Genomine Advanced Biotechnology Research Institute, Genomine Inc.) Choi, Yung Hyun (Open Laboratory for Muscular & Skeletal Disease Control and Department of Biochemistry, Dongeui University College of Korean Medicine) |
1 | Barnes, S. 1998. Evolution of the health benefits of soy isoflavone. Proc. Soc. Exp. Biol. Med. 217, 386-392. DOI |
2 | Brue, B., Dehne, N., Grossmann, N., Jung, M., Namgaladze, D., Schmid, T., von Knethen, A. and Weigert, A. 2013. Redox control of inflammation in macrophages. Antioxid. Redox. Signal. 19, 595-637. DOI |
3 |
Cho, B. O., Ryu, H. W., So, Y., Lee, C. W., Jin, C. H., Yook, H. S., Jeong, Y. W., Park, J. C. and Jeong, I. Y. 2014. Anti-inflammatory effect of mangostenone F in lipopolysaccharidestimulated RAW 264.7 macrophages by suppressing |
4 | Choung, M. G., Baek, I. Y., Kang, S. T., Han, W. Y., Shin, D. C., Moon, H. P. and Kang, K. H. 2001. Isolation and determination of anthocyanins in seed coats of black soybean (Glycine max (L.) Merr.). J. Agric. Food Chem. 49, 5848-5851. DOI |
5 | Dinarell, C. A. 2000. Proinflammatory cytokines. Chest 118, 503-508. DOI |
6 | Golden, B. D. and Abramson, S. B. 1999. Selective cyclooxygenase-2 inhibitors. Rheum. Dis. Clin. North. Am. 25, 359-378. DOI |
7 |
Huang, B. P., Lin, C. H., Chen, H. M., Lin, J. T., Cheng, Y. F. and Kao, S. H. 2015. AMPK activation inhibits expression of proinflammatory mediators through downregulation of PI3K/p38 MAPK and |
8 | Gong, G. L. 2001. Studies on the standardization of manufacture and cancer protection and anti-obesity effects of Kochujang, Master Degree dissertation, Pusan National University, Busan, Korea. |
9 | Guo, S., Qiu, P., Xu, G., Wu, X., Dong, P., Yang, G., Zheng, J., McClements, D. J. and Xiao, H. 2012. Synergistic anti-inflammatory effects of nobiletin and sulforaphane in lipopolysaccharide-stimulated RAW 264.7 cells. J. Agric. Food Chem. 60, 2157-2164. DOI |
10 | Higuchi, M., Hisgahi, N., Taki, H. and Osawa, T. 1990. Cytolytic mechanisms of activated macrophages: Tumor necrosis factor and L-arginine-dependent mechanisms act synergistically as the major cytolytic mechanisms of activated macrophages. J. Immunol. 144, 1425-1431. |
11 | Huang, Y., Li, W., Su, Z. Y. and Kong, A. N. 2015. The complexity of the Nrf2 pathway: beyond the antioxidant response. J. Nutr. Biochem. 26, 1401-1413. DOI |
12 | Kang, K. A. and Hyun, J. W. 2017. Oxidative stress, Nrf2, and epigenetic modification contribute to anticancer drug resistance. Toxicol. Res. 33, 1-5. DOI |
13 | Lee, D. H., Park, J. S., Lee, Y. S., Sung, S. H., Lee, Y. H. and Bae, S. H. 2017. The hypertension drug, verapamil, activates Nrf2 by promoting p62-dependent autophagic Keap1 degradation and prevents acetaminophen-induced cytotoxicity. BMB Rep. 50, 91-96. DOI |
14 | Kasahara, E., Sekiyama, A., Hori, M., Hara, K., Takahashi, N., Konishi, M., Sato, E. F., Matsumoto, S., Okamura, H. and Inoue, M. 2011. Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway. FEBS Lett. 585, 2263-2268. DOI |
15 |
Kauppinen, A., Suuronen, T., Ojala, J., Kaarniranta, K. and Salminen, A. 2013. Antagonistic crosstalk between |
16 | Korea seed & Variety service, https://www.seed.go.kr |
17 | Lee, T. S. and Chau, L. Y. 2002. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat. Med. 8, 240-246. DOI |
18 | Lim, B. O., Jeong, Y. J., Park, M. H., Kim, J. D., Hwang, S. J. and Yu, B. P. 2007. Immunoregulatory effects of Saengshik on DSS-induced inflammatory bowel disease in mouse model system. J. Kor. Soc. Food Sci. Nutr. 36, 32-42. DOI |
19 | Loboda, A., Damulewicz, M., Pyza, E., Jozkowicz, A. and Dulak, J. 2016. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell. Mol. Life Sci. 73, 3221-3247. DOI |
20 | Maines, M. D. 1997. The heme oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37, 517-554. DOI |
21 | Mann, J. R., Backlund, M. G. and DuBois, R. N. 2005. Mechanism of disease: Inflammatory mediators and cancer prevention. Nat. Clin. Pract. Oncol. 2, 202-210. |
22 | Oh, G. S., Pae, H. O. and Chung, H. T. 2003. Nitric oxide priming protects nitric oxide-mediated apoptosis via heme oxygenase-1 induction. Free Radic. Biol. Med. 34, 1136-1145. DOI |
23 | Masferrer, J. L., Zweifel, B. S., Manning, P. T., Hauser, S. D., Leahy, K. M., Smith, W. G., Isakson, P. C. and Seibert, K. 1994. Selective inhibition of inducible cyclooxygenase 2 in vivo is anti inflammatory and nonulcerogenic. Proc. Natl. Acad. Sci. USA. 91, 3228-3232. DOI |
24 | Mills, E. L. and O'Neill, L. A. 2016. Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal. Eur. J. Immunol. 46, 13-21. DOI |
25 | Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P. and Malik, A. B. 2014. Reactive oxygen species in inflammation and tissue injury. Antioxid. Redox Signal. 20, 1126-1167. DOI |
26 | Otterbein, L. E. and Chai, A. M. 2000. Heme oxygenase: colors of defense against cellular stress. Am. J. Physiol. Lung Cell. Mol. Physiol. 279, 1029-1037. DOI |
27 | Pearson, G., Robinson, F., Beers Gibson, T., Xu, B. E., Karandikar, M., Berman, K. and Cobb, M. H. 2001. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183. |
28 | Pittala, V., Salerno, L., Romeo, G., Modica, M. N. and Siracusa, M. A. 2013. A focus on heme oxygenase-1 (HO-1) inhibitors. Curr. Med. Chem. 20, 3711-3732. DOI |
29 | Raingeaud, J., Whitmarsh, A. J., Barrett, T., Derijard, B. and Davis, R. J. 1996. MKK3- and MKK6-regulated gene expressionis is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell Biol. 16, 1247-1255. DOI |
30 | Record, I. R., Dreosit, I. E. and Mclnerney, J. K. 1995. The antioxidant activity of genistein in vitro. J. Nutr. Biochem. 6, 481-485. DOI |
31 | Sirisinha, S. 2011. Insight into the mechanisms regulating immune homeostasis in health and disease. Asian Pac. J. Allergy Immunol. 29, 1-14. |
32 | Rural Development Administration National Institute of Crop Science, Republic of Korea, www.nics.go.kr |
33 | Ryter, S. W. and Choi, A. M. 2016. Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation. Transl. Res. 167, 7-34. DOI |
34 | Motterlini, R. and Foresti, R. 2014. Heme oxygenase-1 as a target for drug discovery. Antioxid. Redox Signal. 20, 1810-1826. DOI |
35 | Stuehr, H. H., Kwon, N. S., Weise, M. and Nathan, C. 1991. Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: and FAD- and FMN-containing flavoprotein. Proc. Natl. Acad. Sci. USA. 88, 7773-7777. DOI |
36 | Tan, H. Y., Wang, N., Li, S., Hong, M., Wang, X. and Feng, Y. 2016. The reactive oxygen species in macrophage polarization: Reflecting its dual role in progression and treatment of human diseases. Oxid. Med. Cell. Longeva. 2016, 2795090. |
37 | Tomomatsu, H. 1994. Health effects of oligosaccharides. Food Technol. 48, 61-65. |
38 | Tsan, M. F. 2006. Toll-like receptors, inflammation and cancer. Semin Cancer Biol. 16, 32-37. DOI |
39 | Wei, H., Cai, Q. and Rahn, R. 1996. Inhibition of UV light and fenton reaction-induced oxidative DNA damage by the soybean isoflacone genistein. Carcinogenesis 17, 73-77. DOI |
40 | Willoughby, D. A. 1975. Human arthritis applied to animal models. Towards a better therapy. Ann. Rheum. Dis. 34, 471-478. DOI |
41 |
Yang, J. L., Jang, J. H., Radliakrishnan, V., Kim, Y. H. and Song, Y. S. 2008. |
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