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http://dx.doi.org/10.5352/JLS.2018.28.1.58

Effects of Extracts of Monascus-fermented Angelica gigas Nakai in High-fat Diet-induced Obesity in Rats  

Kim, Young Wan (Department of Biotechnology, Dong-A University)
Kim, Tae Hoon (Department of Biotechnology, Dong-A University)
Sim, So Yeon (Department of Biotechnology, Dong-A University)
Ahn, Hee Young (Department of Biotechnology, Dong-A University)
Park, Kyu Rim (Nature & Enzyme Co., Ltd.)
Kim, Jung Wook (Nature & Enzyme Co., Ltd.)
Cho, Young Su (Department of Biotechnology, Dong-A University)
Publication Information
Journal of Life Science / v.28, no.1, 2018 , pp. 58-67 More about this Journal
Abstract
This study aimed to identify the effects of extracts of fermented Angelica gigas Nakai (A. gigas) with a Monascus purpureus strain on anti-obesity in a high-fat diet (HFD)-induced obesity rat model. Male Sprague-Dawley rats were randomly divided into seven dietary groups (n=8 per group), as follows: a normal diet group (N) and six HFD groups (C: control, HFD and no treatment; AG: HFD +10% A. gigas extracts; FAG2.5: HFD +2.5% fermented A. gigas extracts; FAG5: HFD +5% fermented A. gigas extracts; FAG10: HFD +10% fermented A. gigas extracts; GC: HFD + Garcinia cambogia extracts). FAG-fed rats exhibited effectively lowered rates of increasing body weight and visceral fat accumulation in the HFD-induced obesity model. The activities of several hepatic marker enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP), were increased with HFD-induced obesity, but levels of these marker enzymes were significantly decreased in FAG-fed rats. The consumption of FAG reduced triglyceride concentrations in serum to normal levels. FAG-fed rats showed effectively increased leptin concentrations in the HFD-induced obesity model. HFD ingestion induced a significant increase in the thiobarbituric acid reactive substances (TBARS) levels, which was decreased in FAG-fed rats. Hematoxylin and eosin staining and Oil Red O staining of the liver showed that the lipid deposits were decreased via FAG feeding. Moreover, hematoxylin and eosin staining of epididymal adipose adipose tissue showed that the adipocyte were decreased by feeding FAG.
Keywords
Angelica gigas Nakai; fermentation; lard; Monascus purpureus; obesity;
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