Cytoprotective Effects of Schisandrin A against Hydrogen Peroxide-induced Oxidative Stress in SW1353 Human Chondrocytes
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Jeong, Jin-Woo
(Open Lab. for Muscular & Skeletal Disease Control and Department of Biochemistry and Dongeui University College of Korean Medicine)
Choi, Eun Ok (Open Lab. for Muscular & Skeletal Disease Control and Department of Biochemistry and Dongeui University College of Korean Medicine) Kwon, Da Hye (Open Lab. for Muscular & Skeletal Disease Control and Department of Biochemistry and Dongeui University College of Korean Medicine) Kim, Bum Hoi (Department of Anatomy, Dongeui University College of Korean Medicine) Park, Dong Il (Department of Internal Medicine, Dongeui University College of Korean Medicine) Hwang, Hye Jin (Anti-Aging Research Center and Blue Bio Industry RIC, Dongeui University) Kim, Byung Woo (Anti-Aging Research Center and Blue Bio Industry RIC, Dongeui University) Choi, Yung Hyun (Open Lab. for Muscular & Skeletal Disease Control and Department of Biochemistry and Dongeui University College of Korean Medicine) |
1 | Kim, S. R., Lee, M. K., Koo, K. A., Kim, S. H., Sung, S. H., Lee, N. G., Markelonis, G. J., Oh, T. H., Yang, J. H. and Kim, Y. C. 2004. Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamate-induced toxicity. J. Neurosci. Res. 76, 397-405. DOI |
2 | Kroemer, G., Galluzzi, L. and Brenner, C. 2007. Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87, 99-163. DOI |
3 | Leong, P. K., Wong, H. S., Chen, J., Chan, W. M., Leung, H. Y. and Ko, K. M. 2016: Differential action between schisandrin A and schisandrin B in eliciting an anti-inflammatory action: The depletion of reduced glutathione and the induction of an antioxidant response. PLoS One 11, e0155879. DOI |
4 | Park, S. Y., Park, S. J., Park, T. G., Rajasekar, S., Lee, S. J. and Choi, Y. W. 2013. Schizandrin C exerts anti-neuroinflammatory effects by upregulating phase II detoxifying/ antioxidant enzymes in microglia. Int. Immunopharmacol. 17, 415-426. DOI |
5 | Qun, E., Tang, M., Zhang, X., Shi, Y., Wang, D., Gu, Y., Li, S., Liang, X., Wang, Z. and Wang, C. 2015. Protection of seven dibenzocyclooctadiene lignans from Schisandra chinensis against serum and glucose deprivation injury in SH-SY5Y cells. Cell Biol. Int. 39, 1418-1424. DOI |
6 | Rahmati, M., Mobasheri, A. and Mozafari, M. 2016. Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges. Bone 85, 81-90. DOI |
7 | Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. and Bonner, W. M. 1998. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868. DOI |
8 | Rosen, A. and Casciola-Rosen, L. 1997. Macromolecular substrates for the ICE-like proteases during apoptosis. J. Cell. Biochem. 64, 50-54. DOI |
9 |
Song, F., Zeng, K., Liao, L., Yu, Q., Tu, P. and Wang, X. 2016. Schizandrin A inhibits microglia-mediated neuroninflammation through inhibiting TRAF6-NF- |
10 | Sakata, S., Hayashi, S., Fujishiro, T., Kawakita, K., Kanzaki, N., Hashimoto, S., Iwasa, K., Chinzei, N., Kihara, S., Haneda, M., Ueha, T., Nishiyama, T., Kuroda, R. and Kurosaka, M. 2015. Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid. J. Orthop. Res. 33, 359-365. DOI |
11 | Sutipornpalangkul, W., Morales, N. P. and Harnroongroj, T. 2009. Free radicals in primary knee osteoarthritis. J. Med. Assoc. Thai 92, S268-S274. |
12 | Wang, C. P., Li, G. C., Shi, Y. W., Zhang, X. C., Li, J. L., Wang, Z. W., Ding, F. and Liang, X. M. 2014. Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/ reperfusion-induced cell injury in primary culture of rat cortical neurons. J. Physiol. Biochem. 70, 735-747. DOI |
13 | Xiao, W. L., Huang, S. X., Wang, R. R., Zhong, J. L., Gao, X. M., He, F., Pu, J. X., Lu, Y., Zheng, Y. T., Zheng, Q. T. and Sun, H. D. 2008. Nortriterpenoids and lignans from Schisandra sphenanthera. Phytochemistry 69, 2862-2866. DOI |
14 | Decker, P. and Muller, S. 2002. Modulating poly (ADP-ribose) polymerase activity: potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr. Pharm. Biotechnol. 3, 275-283. DOI |
15 |
Xie, Y., Hao, H., Wang, H., Guo, C., Kang, A. and Wang, G. 2014. Reversing effects of lignans on |
16 | Asada, S., Fukuda, K., Nishisaka, F., Matsukawa, M. and Hamanisi, C. 2001. Hydrogen peroxide induces apoptosis of chondrocytes; involvement of calcium ion and extracellular signal-regulated protein kinase. Inflamm. Res. 50, 19-23. DOI |
17 | Ba, Q., Cui, C., Wen, L., Feng, S., Zhou, J. and Yang, K. 2015. Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson's disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway. Biomed. Pharmacother. 75, 165-172. DOI |
18 |
Checker, R., Patwardhan, R. S., Sharma, D., Menon, J., Thoh, M., Bhilwade, H. N., Konishi, T. and Sandur, S. K. 2012. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF- |
19 | Chun, J. N., Cho, M., So, I. and Jeon, J. H. 2014. The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: a review of the molecular mechanisms. Fitoterapia 97, 224-233. DOI |
20 | Dave, M., Attur, M., Palmer, G., Al-Mussawir, H. E., Kennish, L., Patel, J. and Abramson, S. B. 2008. The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production. Arthritis Rheum. 58, 2786-2797. DOI |
21 | Dong, Q., Hou, H., Wu, J. and Chen, Y. 2016. The Nrf2-ARE pathway is associated with schisandrin b attenuating benzo(a)pyrene-induced HTR cells damages in vitro. Environ. Toxicol. 31, 1439-1449. DOI |
22 | Fleury, C., Mignotte, B. and Vayssiere, J. L. 2002. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84, 131-141. DOI |
23 | Galluzzi, L., Morselli, E., Kepp, O. and Kroemer, G. 2009. Targeting post-mitochondrial effectors of apoptosis for neuroprotection. Biochim. Biophys. Acta. 1787, 402-413. DOI |
24 | Gao, C., Chen, H., Niu, C., Hu, J. and Cao, B. 2017. Protective effect of Schizandrin B against damage of UVB irradiated skin cells depend on inhibition of inflammatory pathways. Bioengineered 8, 36-44. DOI |
25 | Hwang, H. S. and Kim, H. A. 2015. Chondrocyte apoptosis in the pathogenesis of ssteoarthritis. Int. J. Mol. Sci. 16, 26035-26054. DOI |
26 | Goldring, M. B. and Goldring, S. R. 2007. Osteoarthritis. J. Cell. Physiol. 213, 626-634. DOI |
27 | Hadjigogos, K. 2003. The role of free radicals in the pathogenesis of rheumatoid arthritis. Panminerva. Med. 45, 7-13. |
28 | Huyke, C., Engel, K., Simon-Haarhaus, B., Quirin, K. W. and Schempp, C. M. 2007. Composition and biological activity of different extracts from Schisandra sphenanthera and Schisandra chinensis. Planta Med. 73, 1116-1126. DOI |
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