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http://dx.doi.org/10.5352/JLS.2017.27.3.355

Effect of the Extract of Hydrangea Dulcis Folium on Alcohol-induced Psychiatric Deficits  

Kim, Dong Hyun (Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University)
Park, Hye Jin (Department of Medicinal Biotechnology, College of Natural Resources and Life Science, Dong-A University)
Jung, Ji Wook (Division of Bio-technology and Convergence, College of Herbal Bio-industry, Daegu Haany University)
Lee, Seungheon (Department of Marine Life Sciences, School of Marine Biomedical Sciences, College of Ocean Sciences, Jeju National University)
Publication Information
Journal of Life Science / v.27, no.3, 2017 , pp. 355-360 More about this Journal
Abstract
Consumption of high doses of ethanol can lead to amnesia, which often manifests as a blackout. This incoordination of blackout may be a major cause in various social problems in alcohol consumption. However, there is still no treatment for preventing these alcohol-induced problems. Hydrangeae dulcis folium is a drug or a tea which is made from the fermented and dried leaves of Hydrangea serrata Seringe. The present study, we tested the ethanol extract of the Hydrangeae dulcis folium (EHDF) on ethanol-induced psychological deficits. To test behavioral deficits, an object recognition test was conducted using a mouse model. To evaluate synaptic deficits, N-methyl-D-aspartate (NMDA) receptor-mediated excitatory postsynaptic potential EPSP and long-term potentiation (LTP) in the mouse hippocampal slices were tested, as they are known to be vulnerable to ethanol and are associated with ethanol-induced amnesia. In the tests, ethanol (1 g/kg, i.p.) impaired object recognition memory, but EHDF (10 or 30 mg/kg) prevented this impairment in object recognition test. Interestingly, EHDF ($30{\mu}g/ml$) significantly ameliorated ethanol-induced LTP and NMDA receptor-mediated synaptic transmission in the hippocampal slices. EHDF prevented ethanol-induced object recognition memory deficits induced by ethanol. Interestingly, EHDF significantly ameliorated ethanol-induced LTP and NMDA receptor- mediated synaptic transmission in the hippocampal slices.
Keywords
Ethanol; hydrangea dulcis folium; NMDA receptor; synaptic plasticity;
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